Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)

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Accession:153355
"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. ... We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics. "
Reference:
1 . Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart motor neuron (HE);
Channel(s): I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Temporal Pattern Generation; Detailed Neuronal Models; Parameter sensitivity; Conductance distributions;
Implementer(s): Lamb, Damon [Damon.Lamb at neurology.ufl.edu];
Search NeuronDB for information about:  I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
/
LambCalabrese2013
lgenesis-noX
include
absff_func_ext.h
absff_header.h
axon_ext.h
axon_g@.h
axon_struct.h
basic_g@.h
buf_defs.h
buf_ext.h
buf_struct.h
buffer_g@.h
conc_defs.h
conc_ext.h
conc_struct.h
concen_g@.h
copyright.h
dev_ext.h
dev_struct.h
devices_g@.h
diskio_defs.h
diskio_ext.h
diskio_func_ext.h
diskio_g@.h
diskio_struct.h
fac_debug.h
fac_defs.h
fac_ext.h
fac_struct.h
FMT1.h
FMT1_ext.h
FMT1_func_ext.h
FMT1_struct.h
hash.h
header.h
hh_ext.h
hh_g@.h
hh_struct.h
hh_struct_defs.h
hines_defs.h
hines_ext.h
hines_g@.h
hines_struct.h
interface.h
iofunc.h
kin_ext.h
kin_g@.h
kin_struct.h
netcdf.h
netcdf_ext.h
netcdf_func_ext.h
netcdf_struct.h
newconn_defs.h
newconn_ext.h
newconn_g@.h
newconn_struct.h
nrutil.h
NULLArgv.h
olf_ext.h
olf_g@.h
olf_struct.h
out_defs.h
out_ext.h
out_struct.h
output_g@.h
par_ext.h
param_defs.h
param_ext.h
param_g@.h
param_struct.h
per_ext.h
per_struct.h
personal_g@.h
pore_ext.h
pore_g@.h
pore_struct.h
profile.h
seg.h
seg_defs.h
seg_ext.h
seg_struct.h
segment_g@.h
shell.h
shell_defs.h
shell_ext.h
shell_func_ext.h
shell_g@.h
shell_struct.h
sim.h
sim_defs.h
sim_ext.h
sim_func_ext.h
sim_struct.h
sim_version.h
simconn_ext.h
simconn_g@.h
simconn_struct.h *
spike_ext.h
spike_struct.h
sprng.h
sprng_f.h
struct_defs.h
syn_ext.h
syn_struct.h
synapse_g@.h
synaptic_event.h
SynGS_ext.h *
SynGS_struct.h
system_deps.h
tool_ext.h
tool_struct.h
toolconn_ext.h
toolconn_g@.h
toolconn_struct.h *
tools.h
user_ext.h
user_g@.h
user_struct.h
                            
/* Version EDS22c 97/12/02 Erik De Schutter,  BBF-UIA 1/95-12/97 */

/*
** $Id: hines_ext.h,v 1.3 2005/07/20 20:02:00 svitak Exp $
** $Log: hines_ext.h,v $
** Revision 1.3  2005/07/20 20:02:00  svitak
** Added standard header files needed by some architectures.
**
** Revision 1.2  2005/06/27 19:00:40  svitak
** Added explicit types to untyped functions and fixed return values as
** appropriate. Initialized values explicitly when it was unclear if
** they were being used uninitialized (may not apply to all files being
** checked in in this batch).
**
** Revision 1.1.1.1  2005/06/14 04:38:32  svitak
** Import from snapshot of CalTech CVS tree of June 8, 2005
**
** Revision 1.7  2001/04/25 17:16:58  mhucka
** Misc. small changes to improve portability and address compiler warnings.
**
** Revision 1.6  1999/10/17 21:47:27  mhucka
** Added return value declarations for a number of functions, in an effort to
** reduce the number of compile-time warnings.
**
** Revision 1.5  1999/10/17 21:39:37  mhucka
** New version of Hines code from Erik De Schutter, dated 30 March 1999
** and including an update to hines.c from Erik from June 1999.  This version
** does not include changes to support Red Hat 6.0 and the Cray T3E, which
** will need to be incorporated in a separate revision update.
**
 * EDS22c revison: EDS BBF-UIA 97/12/02-97/12/02
 * Moved all typedefs to this hines_struct.h file
 #
** Revision 1.2  1997/05/28 22:53:56  dhb
** Replaced with the version from Antwerp GENESIS 21e
**
** Revision 1.1  1992/12/11  19:03:12  dhb
** Initial revision
**
*/

#ifndef HINES_EXT_H
#define HINES_EXT_H

#include <math.h>
#include <stdio.h>
#include "sim_ext.h"
#include "shell_func_ext.h"
#include "conc_struct.h"
#include "dev_struct.h"
#include "hines_defs.h"
#include "hines_struct.h"
#include "olf_defs.h"
#include "olf_struct.h"
#include "seg_struct.h"
#include "newconn_struct.h"
#include "synaptic_event.h"

#ifdef __STDC__
int h_eventaction( Element *src, Element *dst, int index, int time );
#else
int h_init();
int h2_init();
int do_hget_children();
int h_hh_chip_init();
int h_init_conc_chip();
int h_init_conc_solve();
int do_fast_hsetup();
int h_hh_init();
int do_duplicate();
int hfind_elm();
int h_nernst_init();
int hstore_name();
int hchild_compare();
int h_has_output();
int duplicate_tables();
#endif

#endif

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