Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)

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Accession:153355
"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. ... We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics. "
Reference:
1 . Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart motor neuron (HE);
Channel(s): I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Temporal Pattern Generation; Detailed Neuronal Models; Parameter sensitivity; Conductance distributions;
Implementer(s): Lamb, Damon [Damon.Lamb at neurology.ufl.edu];
Search NeuronDB for information about:  I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
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LambCalabrese2013
lgenesis-noX
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absff_func_ext.h
absff_header.h
axon_ext.h
axon_g@.h
axon_struct.h
basic_g@.h
buf_defs.h
buf_ext.h
buf_struct.h
buffer_g@.h
conc_defs.h
conc_ext.h
conc_struct.h
concen_g@.h
copyright.h
dev_ext.h
dev_struct.h
devices_g@.h
diskio_defs.h
diskio_ext.h
diskio_func_ext.h
diskio_g@.h
diskio_struct.h
fac_debug.h
fac_defs.h
fac_ext.h
fac_struct.h
FMT1.h
FMT1_ext.h
FMT1_func_ext.h
FMT1_struct.h
hash.h
header.h
hh_ext.h
hh_g@.h
hh_struct.h
hh_struct_defs.h
hines_defs.h
hines_ext.h
hines_g@.h
hines_struct.h
interface.h
iofunc.h
kin_ext.h
kin_g@.h
kin_struct.h
netcdf.h
netcdf_ext.h
netcdf_func_ext.h
netcdf_struct.h
newconn_defs.h
newconn_ext.h
newconn_g@.h
newconn_struct.h
nrutil.h
NULLArgv.h
olf_ext.h
olf_g@.h
olf_struct.h
out_defs.h
out_ext.h
out_struct.h
output_g@.h
par_ext.h
param_defs.h
param_ext.h
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per_ext.h
per_struct.h
personal_g@.h
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pore_struct.h
profile.h
seg.h
seg_defs.h
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segment_g@.h
shell.h
shell_defs.h
shell_ext.h
shell_func_ext.h
shell_g@.h
shell_struct.h
sim.h
sim_defs.h
sim_ext.h
sim_func_ext.h
sim_struct.h
sim_version.h
simconn_ext.h
simconn_g@.h
simconn_struct.h *
spike_ext.h
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sprng.h
sprng_f.h
struct_defs.h
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SynGS_ext.h *
SynGS_struct.h
system_deps.h
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tool_struct.h
toolconn_ext.h
toolconn_g@.h
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tools.h
user_ext.h
user_g@.h
user_struct.h
                            
#ifndef _interface_h_
#define _interface_h_

#ifndef ANSI_ARGS
#ifdef __STDC__
#define ANSI_ARGS(args) args
#else
#define ANSI_ARGS(args) ()
#endif
#endif

#ifdef __cplusplus
extern "C" {
#endif

int get_rn_int ANSI_ARGS((int *igenptr));
float get_rn_flt ANSI_ARGS((int *igenptr));
double get_rn_dbl ANSI_ARGS((int *igenptr));
int *init_rng ANSI_ARGS(( int gennum, int total_gen,  int seed,
			  int mult));
int spawn_rng ANSI_ARGS((int *igenptr, int nspawned, int ***newgens, int checkid) );
int make_new_seed ANSI_ARGS((void));
int make_new_seed_mpi ANSI_ARGS((void));
int get_seed__rng ANSI_ARGS((int *genptr));
int free_rng ANSI_ARGS((int *genptr));
int pack_rng ANSI_ARGS(( int *genptr, char **buffer));
int *unpack_rng ANSI_ARGS(( char *packed));
int print_rng ANSI_ARGS(( int *igen));
int *checkID ANSI_ARGS(( int *igen));
int *addID ANSI_ARGS(( int *igen));
int *deleteID ANSI_ARGS(( int *igen));


int *init_rng_simple ANSI_ARGS(( int seed,  int mult));
int *init_rng_simple_mpi ANSI_ARGS(( int seed,  int mult));
int get_rn_int_simple ANSI_ARGS((void));
int get_rn_int_simple_mpi ANSI_ARGS((void));
float get_rn_flt_simple ANSI_ARGS((void));
float get_rn_flt_simple_mpi ANSI_ARGS((void));
double get_rn_dbl_simple ANSI_ARGS((void));
double get_rn_dbl_simple_mpi ANSI_ARGS((void));
int pack_rng_simple ANSI_ARGS((char **buffer));
int *unpack_rng_simple ANSI_ARGS(( char *packed));
int print_rng_simple ANSI_ARGS((void));


#ifdef __cplusplus
}
#endif


#endif

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