Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)

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Accession:153355
"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. ... We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics. "
Reference:
1 . Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart motor neuron (HE);
Channel(s): I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Temporal Pattern Generation; Detailed Neuronal Models; Parameter sensitivity; Conductance distributions;
Implementer(s): Lamb, Damon [Damon.Lamb at neurology.ufl.edu];
Search NeuronDB for information about:  I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
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LambCalabrese2013
lgenesis-noX
include
absff_func_ext.h
absff_header.h
axon_ext.h
axon_g@.h
axon_struct.h
basic_g@.h
buf_defs.h
buf_ext.h
buf_struct.h
buffer_g@.h
conc_defs.h
conc_ext.h
conc_struct.h
concen_g@.h
copyright.h
dev_ext.h
dev_struct.h
devices_g@.h
diskio_defs.h
diskio_ext.h
diskio_func_ext.h
diskio_g@.h
diskio_struct.h
fac_debug.h
fac_defs.h
fac_ext.h
fac_struct.h
FMT1.h
FMT1_ext.h
FMT1_func_ext.h
FMT1_struct.h
hash.h
header.h
hh_ext.h
hh_g@.h
hh_struct.h
hh_struct_defs.h
hines_defs.h
hines_ext.h
hines_g@.h
hines_struct.h
interface.h
iofunc.h
kin_ext.h
kin_g@.h
kin_struct.h
netcdf.h
netcdf_ext.h
netcdf_func_ext.h
netcdf_struct.h
newconn_defs.h
newconn_ext.h
newconn_g@.h
newconn_struct.h
nrutil.h
NULLArgv.h
olf_ext.h
olf_g@.h
olf_struct.h
out_defs.h
out_ext.h
out_struct.h
output_g@.h
par_ext.h
param_defs.h
param_ext.h
param_g@.h
param_struct.h
per_ext.h
per_struct.h
personal_g@.h
pore_ext.h
pore_g@.h
pore_struct.h
profile.h
seg.h
seg_defs.h
seg_ext.h
seg_struct.h
segment_g@.h
shell.h
shell_defs.h
shell_ext.h
shell_func_ext.h
shell_g@.h
shell_struct.h
sim.h
sim_defs.h
sim_ext.h
sim_func_ext.h
sim_struct.h
sim_version.h
simconn_ext.h
simconn_g@.h
simconn_struct.h *
spike_ext.h
spike_struct.h
sprng.h
sprng_f.h
struct_defs.h
syn_ext.h
syn_struct.h
synapse_g@.h
synaptic_event.h
SynGS_ext.h *
SynGS_struct.h
system_deps.h
tool_ext.h
tool_struct.h
toolconn_ext.h
toolconn_g@.h
toolconn_struct.h *
tools.h
user_ext.h
user_g@.h
user_struct.h
                            
/* $Id: newconn_defs.h,v 1.1.1.1 2005/06/14 04:38:29 svitak Exp $
** $Log: newconn_defs.h,v $
** Revision 1.1.1.1  2005/06/14 04:38:29  svitak
** Import from snapshot of CalTech CVS tree of June 8, 2005
**
** Revision 1.3  2000/09/21 19:32:43  mhucka
** Wrapped the definition of M_E inside #ifndef M_E, because on some systems
** like AIX, it ends up getting defined twice.
**
** Revision 1.2  1996/07/22 23:38:42  dhb
** Changes from Makw Vanier:
**   Generic handling of synchan types
**
 * Revision 1.1  1995/01/11  23:09:02  dhb
 * Initial revision
 *
*/

#ifndef M_E
#define M_E   2.7182818284590452354 
#endif

#ifndef TINY
#define TINY 1e-8
#endif

/* message types for randomspike */

#define RATE 0
#define MINMAX 1

/* message types for synchan */
 
#define SPIKE             -1 
#define VOLTAGE            0
#define ACTIVATION         1
#define RAND_ACTIVATION    2
#define MOD                3 
#define WEIGHT_CHANGE_MOD  4

/* extra action for synchan2 */
#define RESETBUFFER 1001


/*
 * Macros for setting and testing flags.
 */

#define SPIKE_THIS_TIME_STEP  0x1
#define SPIKE_BETWEEN_UPDATES 0x2
 
#define IS_FLAG_SET(A,B) ((A)&(B))
#define SET_FLAG(A,B)    ((B)=(B)|(A))
#define CLEAR_FLAG(A,B)  ((B)=((B)&(~(A))))



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