Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)

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Accession:153355
"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. ... We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics. "
Reference:
1 . Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart motor neuron (HE);
Channel(s): I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Temporal Pattern Generation; Detailed Neuronal Models; Parameter sensitivity; Conductance distributions;
Implementer(s): Lamb, Damon [Damon.Lamb at neurology.ufl.edu];
Search NeuronDB for information about:  I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
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LambCalabrese2013
lgenesis-noX
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absff_func_ext.h
absff_header.h
axon_ext.h
axon_g@.h
axon_struct.h
basic_g@.h
buf_defs.h
buf_ext.h
buf_struct.h
buffer_g@.h
conc_defs.h
conc_ext.h
conc_struct.h
concen_g@.h
copyright.h
dev_ext.h
dev_struct.h
devices_g@.h
diskio_defs.h
diskio_ext.h
diskio_func_ext.h
diskio_g@.h
diskio_struct.h
fac_debug.h
fac_defs.h
fac_ext.h
fac_struct.h
FMT1.h
FMT1_ext.h
FMT1_func_ext.h
FMT1_struct.h
hash.h
header.h
hh_ext.h
hh_g@.h
hh_struct.h
hh_struct_defs.h
hines_defs.h
hines_ext.h
hines_g@.h
hines_struct.h
interface.h
iofunc.h
kin_ext.h
kin_g@.h
kin_struct.h
netcdf.h
netcdf_ext.h
netcdf_func_ext.h
netcdf_struct.h
newconn_defs.h
newconn_ext.h
newconn_g@.h
newconn_struct.h
nrutil.h
NULLArgv.h
olf_ext.h
olf_g@.h
olf_struct.h
out_defs.h
out_ext.h
out_struct.h
output_g@.h
par_ext.h
param_defs.h
param_ext.h
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param_struct.h
per_ext.h
per_struct.h
personal_g@.h
pore_ext.h
pore_g@.h
pore_struct.h
profile.h
seg.h
seg_defs.h
seg_ext.h
seg_struct.h
segment_g@.h
shell.h
shell_defs.h
shell_ext.h
shell_func_ext.h
shell_g@.h
shell_struct.h
sim.h
sim_defs.h
sim_ext.h
sim_func_ext.h
sim_struct.h
sim_version.h
simconn_ext.h
simconn_g@.h
simconn_struct.h *
spike_ext.h
spike_struct.h
sprng.h
sprng_f.h
struct_defs.h
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syn_struct.h
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synaptic_event.h
SynGS_ext.h *
SynGS_struct.h
system_deps.h
tool_ext.h
tool_struct.h
toolconn_ext.h
toolconn_g@.h
toolconn_struct.h *
tools.h
user_ext.h
user_g@.h
user_struct.h
                            
#define TABCREATE 200
#define TABFILL 201
#define TABDELETE 202
#define TABSAVE 203
#define TABREAD 204
#define TAB2FIELDS 207
#define TABOP 208
#define receptor_ODOR 0
#define receptor_GAIN 1
#define receptor2_VOLTAGE 0
#define receptor2_ODOR 1
#define receptor2_MODULATION 2
#define tabgate_VOLTAGE 0
#define tabgate_SUM_ALPHA 2
#define tabgate_PRD_ALPHA 3
#define tabgate_SUM_BETA 4
#define tabgate_PRD_BETA 5
#define tabgate_EREST 6
#define table_INPUT 0
#define table_SUM 1
#define table_PRD 2
#define table_INPUT2 3
#define table2D_INPUT 0
#define table2D_SUM 1
#define table2D_PRD 2
#define table2D_X 3
#define table2D_Y 4
#define tabchannel_VOLTAGE 0
#define tabchannel_CONCEN 1
#define tabchannel_DOMAINCONC 3
#define tabchannel_EK 4
#define tabchannel_ADD_GBAR 5
#define tab2Dchannel_VOLTAGE 0
#define tab2Dchannel_CONCEN 1
#define tab2Dchannel_CONCEN1 1
#define tab2Dchannel_CONCEN2 2
#define tab2Dchannel_DOMAINCONC 3
#define tab2Dchannel_EK 4
#define tab2Dchannel_ADD_GBAR 5
#define tabcurrent_VOLTAGE 0
#define tabcurrent_CONCEN 1
#define tabcurrent_CONCEN1 1
#define tabcurrent_CONCEN2 2
#define tabcurrent_DOMAINCONC 3
#define tabcurrent_ADD_GBAR 5
#define ddsyn_VOLTAGE 0
#define ddsyn_ACTIVATION 1
#define ddsyn_V_PRESYN 2
#define ddsyn_RAND_ACTIVATION 3

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