Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)

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Accession:153355
"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. ... We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics. "
Reference:
1 . Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart motor neuron (HE);
Channel(s): I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Temporal Pattern Generation; Detailed Neuronal Models; Parameter sensitivity; Conductance distributions;
Implementer(s): Lamb, Damon [Damon.Lamb at neurology.ufl.edu];
Search NeuronDB for information about:  I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
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LambCalabrese2013
lgenesis-noX
include
absff_func_ext.h
absff_header.h
axon_ext.h
axon_g@.h
axon_struct.h
basic_g@.h
buf_defs.h
buf_ext.h
buf_struct.h
buffer_g@.h
conc_defs.h
conc_ext.h
conc_struct.h
concen_g@.h
copyright.h
dev_ext.h
dev_struct.h
devices_g@.h
diskio_defs.h
diskio_ext.h
diskio_func_ext.h
diskio_g@.h
diskio_struct.h
fac_debug.h
fac_defs.h
fac_ext.h
fac_struct.h
FMT1.h
FMT1_ext.h
FMT1_func_ext.h
FMT1_struct.h
hash.h
header.h
hh_ext.h
hh_g@.h
hh_struct.h
hh_struct_defs.h
hines_defs.h
hines_ext.h
hines_g@.h
hines_struct.h
interface.h
iofunc.h
kin_ext.h
kin_g@.h
kin_struct.h
netcdf.h
netcdf_ext.h
netcdf_func_ext.h
netcdf_struct.h
newconn_defs.h
newconn_ext.h
newconn_g@.h
newconn_struct.h
nrutil.h
NULLArgv.h
olf_ext.h
olf_g@.h
olf_struct.h
out_defs.h
out_ext.h
out_struct.h
output_g@.h
par_ext.h
param_defs.h
param_ext.h
param_g@.h
param_struct.h
per_ext.h
per_struct.h
personal_g@.h
pore_ext.h
pore_g@.h
pore_struct.h
profile.h
seg.h
seg_defs.h
seg_ext.h
seg_struct.h
segment_g@.h
shell.h
shell_defs.h
shell_ext.h
shell_func_ext.h
shell_g@.h
shell_struct.h
sim.h
sim_defs.h
sim_ext.h
sim_func_ext.h
sim_struct.h
sim_version.h
simconn_ext.h
simconn_g@.h
simconn_struct.h *
spike_ext.h
spike_struct.h
sprng.h
sprng_f.h
struct_defs.h
syn_ext.h
syn_struct.h
synapse_g@.h
synaptic_event.h
SynGS_ext.h *
SynGS_struct.h
system_deps.h
tool_ext.h
tool_struct.h
toolconn_ext.h
toolconn_g@.h
toolconn_struct.h *
tools.h
user_ext.h
user_g@.h
user_struct.h
                            
/*
 *
 * Copyright (c) 1997, 1998, 1999 Michael Christopher Vanier
 * All rights reserved.
 *
 * Permission is hereby granted, without written agreement and without
 * license or royalty fees, to use, copy, modify, and distribute this
 * software and its documentation for any purpose, provided that the
 * above copyright notice and the following two paragraphs appear in
 * all copies of this software.
 *
 * In no event shall Michael Vanier or the Genesis Developer's Group
 * be liable to any party for direct, indirect, special, incidental, or
 * consequential damages arising out of the use of this software and its
 * documentation, even if Michael Vanier and the Genesis Developer's
 * Group have been advised of the possibility of such damage.
 *
 * Michael Vanier and the Genesis Developer's Group specifically
 * disclaim any warranties, including, but not limited to, the implied
 * warranties of merchantability and fitness for a particular purpose.
 * The software provided hereunder is on an "as is" basis, and Michael
 * Vanier and the Genesis Developer's Group have no obligation to
 * provide maintenance, support, updates, enhancements, or modifications.
 *
 */

#ifndef PARAM_EXT_H
#define PARAM_EXT_H

#include <assert.h>
#include <stdlib.h>
#include <string.h>

#include "sim_ext.h"
#include "shell_func_ext.h"
#include "param_defs.h"
#include "param_struct.h"

extern float  rangauss();

/* version of free that checks for NULL pointers: */

extern void paramFree();

/*
 * version of fwrite that checks to make sure it isn't writing
 * from a NULL pointer:
 */

extern size_t paramFwrite();

extern void   CopyParamLabel();
extern double GetparamGA();

#endif  /* PARAM_EXT_H */


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