Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)

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Accession:153355
"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. ... We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics. "
Reference:
1 . Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart motor neuron (HE);
Channel(s): I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Temporal Pattern Generation; Detailed Neuronal Models; Parameter sensitivity; Conductance distributions;
Implementer(s): Lamb, Damon [Damon.Lamb at neurology.ufl.edu];
Search NeuronDB for information about:  I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
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LambCalabrese2013
lgenesis-noX
include
absff_func_ext.h
absff_header.h
axon_ext.h
axon_g@.h
axon_struct.h
basic_g@.h
buf_defs.h
buf_ext.h
buf_struct.h
buffer_g@.h
conc_defs.h
conc_ext.h
conc_struct.h
concen_g@.h
copyright.h
dev_ext.h
dev_struct.h
devices_g@.h
diskio_defs.h
diskio_ext.h
diskio_func_ext.h
diskio_g@.h
diskio_struct.h
fac_debug.h
fac_defs.h
fac_ext.h
fac_struct.h
FMT1.h
FMT1_ext.h
FMT1_func_ext.h
FMT1_struct.h
hash.h
header.h
hh_ext.h
hh_g@.h
hh_struct.h
hh_struct_defs.h
hines_defs.h
hines_ext.h
hines_g@.h
hines_struct.h
interface.h
iofunc.h
kin_ext.h
kin_g@.h
kin_struct.h
netcdf.h
netcdf_ext.h
netcdf_func_ext.h
netcdf_struct.h
newconn_defs.h
newconn_ext.h
newconn_g@.h
newconn_struct.h
nrutil.h
NULLArgv.h
olf_ext.h
olf_g@.h
olf_struct.h
out_defs.h
out_ext.h
out_struct.h
output_g@.h
par_ext.h
param_defs.h
param_ext.h
param_g@.h
param_struct.h
per_ext.h
per_struct.h
personal_g@.h
pore_ext.h
pore_g@.h
pore_struct.h
profile.h
seg.h
seg_defs.h
seg_ext.h
seg_struct.h
segment_g@.h
shell.h
shell_defs.h
shell_ext.h
shell_func_ext.h
shell_g@.h
shell_struct.h
sim.h
sim_defs.h
sim_ext.h
sim_func_ext.h
sim_struct.h
sim_version.h
simconn_ext.h
simconn_g@.h
simconn_struct.h *
spike_ext.h
spike_struct.h
sprng.h
sprng_f.h
struct_defs.h
syn_ext.h
syn_struct.h
synapse_g@.h
synaptic_event.h
SynGS_ext.h *
SynGS_struct.h
system_deps.h
tool_ext.h
tool_struct.h
toolconn_ext.h
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toolconn_struct.h *
tools.h
user_ext.h
user_g@.h
user_struct.h
                            
#define channelA_VOLTAGE 0
#define channelA_ACTIVATION 1
#define channelB_VOLTAGE 0
#define channelB_ACTIVATION 1
#define channelC_ACTIVATION 0
#define channelC_RAND_ACTIVATION 1
#define channelC2_VOLTAGE 0
#define channelC2_ACTIVATION 1
#define channelC2_RAND_ACTIVATION 2
#define channelC3_VOLTAGE 0
#define channelC3_ACTIVATION 1
#define manuelconduct_VOLTAGE 0
#define manuelconduct_ACTIVATION 1
#define manuelconduct_RAND_ACTIVATION 2
#define Ca_concen_I_Ca 0
#define Ca_concen_fI_Ca 1
#define Ca_concen_INCREASE 2
#define Ca_concen_DECREASE 3
#define Ca_concen_BASE 4
#define Mg_block_VOLTAGE 0
#define Mg_block_CHANNEL1 1
#define Mg_block_CHANNEL2 2
#define Mg_block_CHANNEL 2
#define Mg_block_CHARGE 3
#define leakage_VOLTAGE 0
#define compartment_CHANNEL 0
#define compartment_RAXIAL 1
#define compartment_AXIAL 2
#define compartment_INJECT 3
#define compartment_EREST 6
#define symcompartment_CHANNEL 0
#define symcompartment_RAXIAL 1
#define symcompartment_RAXIAL2 2
#define symcompartment_AXIAL 2
#define symcompartment_CONNECTTAIL 1
#define symcompartment_CONNECTHEAD 2
#define symcompartment_INJECT 3
#define symcompartment_CONNECTCROSS 5
#define symcompartment_EREST 6
#define unit_INJECT 0
#define RC_INJECT 0
#define site_ACTIVATION 1
#define ghk_Cin 0
#define ghk_CIN 0
#define ghk_Cout 1
#define ghk_COUT 1
#define ghk_VOLTAGE 3
#define ghk_PERMEABILITY 4
#define izcell_CHANNEL 1
#define izcell_INJECT 0

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