Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)

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Accession:153355
"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. ... We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics. "
Reference:
1 . Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart motor neuron (HE);
Channel(s): I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Temporal Pattern Generation; Detailed Neuronal Models; Parameter sensitivity; Conductance distributions;
Implementer(s): Lamb, Damon [Damon.Lamb at neurology.ufl.edu];
Search NeuronDB for information about:  I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
/
LambCalabrese2013
lgenesis-noX
include
absff_func_ext.h
absff_header.h
axon_ext.h
axon_g@.h
axon_struct.h
basic_g@.h
buf_defs.h
buf_ext.h
buf_struct.h
buffer_g@.h
conc_defs.h
conc_ext.h
conc_struct.h
concen_g@.h
copyright.h
dev_ext.h
dev_struct.h
devices_g@.h
diskio_defs.h
diskio_ext.h
diskio_func_ext.h
diskio_g@.h
diskio_struct.h
fac_debug.h
fac_defs.h
fac_ext.h
fac_struct.h
FMT1.h
FMT1_ext.h
FMT1_func_ext.h
FMT1_struct.h
hash.h
header.h
hh_ext.h
hh_g@.h
hh_struct.h
hh_struct_defs.h
hines_defs.h
hines_ext.h
hines_g@.h
hines_struct.h
interface.h
iofunc.h
kin_ext.h
kin_g@.h
kin_struct.h
netcdf.h
netcdf_ext.h
netcdf_func_ext.h
netcdf_struct.h
newconn_defs.h
newconn_ext.h
newconn_g@.h
newconn_struct.h
nrutil.h
NULLArgv.h
olf_ext.h
olf_g@.h
olf_struct.h
out_defs.h
out_ext.h
out_struct.h
output_g@.h
par_ext.h
param_defs.h
param_ext.h
param_g@.h
param_struct.h
per_ext.h
per_struct.h
personal_g@.h
pore_ext.h
pore_g@.h
pore_struct.h
profile.h
seg.h
seg_defs.h
seg_ext.h
seg_struct.h
segment_g@.h
shell.h
shell_defs.h
shell_ext.h
shell_func_ext.h
shell_g@.h
shell_struct.h
sim.h
sim_defs.h
sim_ext.h
sim_func_ext.h
sim_struct.h
sim_version.h
simconn_ext.h
simconn_g@.h
simconn_struct.h *
spike_ext.h
spike_struct.h
sprng.h
sprng_f.h
struct_defs.h
syn_ext.h
syn_struct.h
synapse_g@.h
synaptic_event.h
SynGS_ext.h *
SynGS_struct.h
system_deps.h
tool_ext.h
tool_struct.h
toolconn_ext.h
toolconn_g@.h
toolconn_struct.h *
tools.h
user_ext.h
user_g@.h
user_struct.h
                            
/*
** $Id: shell_func_ext.h,v 1.7 2005/07/07 19:03:54 svitak Exp $
** $Log: shell_func_ext.h,v $
** Revision 1.7  2005/07/07 19:03:54  svitak
** Eliminated traces of old TraceScript function so as not to confuse it
** with the newer, less usable TraceScript found in ss/eval.c.
**
** Revision 1.6  2005/06/27 19:00:45  svitak
** Added explicit types to untyped functions and fixed return values as
** appropriate. Initialized values explicitly when it was unclear if
** they were being used uninitialized (may not apply to all files being
** checked in in this batch).
**
** Revision 1.5  2005/06/26 08:25:37  svitak
** Provided explicit types for untyped funtions. Fixed return statements to
** match return type.
**
** Revision 1.4  2005/06/24 20:48:18  svitak
** Correct typing of functions returning void.
**
** Revision 1.3  2005/06/20 21:20:15  svitak
** Fixed compiler warnings re: unused variables and functions with no return type.
** Default of int causes compiler to complain about return with no type, so void
** used as return type when none present.
**
** Revision 1.2  2005/06/17 17:37:06  svitak
** Deprecated varargs.h replaced by stdarg.h. Old-style argument lists updated.
** These changes were part of varargs-genesis.patch. Systems without stdarg.h
** will no longer compile.
**
** Revision 1.1.1.1  2005/06/14 04:38:34  svitak
** Import from snapshot of CalTech CVS tree of June 8, 2005
**
** Revision 1.11  2003/03/28 21:10:46  gen-dbeeman
** Changes from Hugo Cornelis to enable debugging commands gctrace and gftrace
**
** Revision 1.10  2001/06/29 21:24:17  mhucka
** Lots of additions, and a reorganization.
**
** Revision 1.9  2001/04/25 17:17:00  mhucka
** Misc. small changes to improve portability and address compiler warnings.
**
** Revision 1.8  2000/09/21 19:38:20  mhucka
** Added declarations for a few more functions.
**
** Revision 1.7  2000/09/07 05:15:58  mhucka
** Added declaration for Autoshell() and new function SetAutoShell().
**
** Revision 1.6  2000/05/19 18:40:05  mhucka
** Added declaration for SearchForNonScript.
**
** Revision 1.5  2000/03/27 10:33:07  mhucka
** Commented out statusline functionality, because it caused GENESIS to send
** control character sequences upon exit and thereby screw up the user's
** terminal.  Also added return type declarations for various things.
**
** Revision 1.4  1999/08/22 04:42:15  mhucka
** Various fixes, mostly for Red Hat Linux 6.0
**
** Revision 1.3  1995/02/22 19:12:58  dhb
** Added GetHistory() extern statement.
**
** Revision 1.2  1994/04/14  16:22:29  dhb
** Added PFI GetFuncAddress() to extern declarations.
**
** Revision 1.1  1992/12/11  19:04:53  dhb
** Initial revision
**
*/

#ifndef SHELL_FUNC_EXT_H
#define SHELL_FUNC_EXT_H

#include <stdlib.h>
#include <string.h>	/* strchr */
#include "result.h"
#include "shell_struct.h"

/*
** PFI is defined in header.h, but some places where PFI is needed can't
** include header.h without a lot of trouble.  So, define it here if needed.
*/
#ifndef PFI_DEFINED
#define PFI_DEFINED
typedef int	(*PFI)();
#endif

#include <string.h>

/*
** Tracing of commands and functions
*/

int GetCommandTraceLevel(void);
int SetCommandTraceLevel(int iLevel);

extern int      AddCleanup();
extern void     AddFunc();
extern void     AddHistory();
extern int      AddJob();
extern void     AddScript();
extern void     AlternatePrompt();
extern char    *ArgListToString();
extern double   Atod();
extern float    Atof();
extern int      Autoshell();
extern int      AuxFuncIndex();
extern int      AvailableCharacters();
extern void     cleareol();
extern void     ClearScriptStack();
extern void     CloseLog();
extern char   **CopyArgv();
extern char    *CopyString();
extern Script  *CurrentScript();
extern FILE    *CurrentScriptFp();
extern int      CurrentScriptLine();
extern int      CurrentScriptLine();
extern char    *CurrentScriptName();
extern void     DefaultPrompt();
extern void     DisableStatusLine();
extern void     do_add_func();
extern void     do_autoshell();
extern int      do_cd();
extern int      do_debug();
extern int      do_debug_func();
extern void     do_echo();
extern void     do_execute();
extern void     do_exit();
extern char    *do_getenv();
extern void     do_getinfo();
extern void     do_load_func();
extern void     do_load_lib();
extern void     do_logoff();
extern int      do_mkdir();
extern void     do_printargs();
extern void     do_printenv();
extern void     do_return();
extern void     do_setenv();
extern void     do_set_prompt();
extern void     do_shell();
extern int      do_silent();
extern void     do_source();
extern int      do_status_message();
extern void     do_where();
extern int      Dynamic();
extern int      EmptyLine();
extern int      EmptyString();
extern void     EnableDynamicLoad();
extern void     EnableHistory();
extern int      EnableScrollRegion();
extern void     EnableStatusLine();
extern void     EndScript();
extern void     EndScript();
extern void     Error();
extern void     ExecuteCleanups();
extern Result   ExecuteCommand();
extern void     ExecuteJobs();
extern void     FreeArgv();
extern void     FreeArgv();
extern void     FreeString();
extern char    *ftoa();
extern int      FuncIndex();
extern void     genesis_tty();
extern char    *getenv();
extern PFI      GetFuncAddress();
extern char    *GetFuncName();
extern char*    GetHistory();
extern int      GetInfo();
extern int      GetLine();
extern char    *GetLineFp();
extern void     HashFunc();
extern void     HashInit();
extern char    *History();
extern int      HistoryCnt();
extern int      IncludeScript();
extern void     inc_prompt();
extern void     InitJobs();
extern void     Interpreter();
extern int      is_alpha();
extern int      is_alphanum();
extern int      IsBatchMode();
extern int      IsBatchMode();
extern int      IsCommand();
extern int      is_data_char();
extern int      is_eol_char();
extern int      IsFile();
extern int      IsHistoryEnabled();
extern int      IsInclude();
extern int      is_index_delimiter();
extern int      is_num();
extern int      IsSilent();
extern int      is_space_char();
extern int      is_str_delimiter();
extern int      IsStringDelimiter();
extern int      IsStringEnd();
extern int      is_str_var_delimiter();
extern int      IsTtyMode();
extern int      is_var_char();
extern int      IsWhiteSpace();
extern char    *itoa();
extern void     LoadFuncInit();
extern void     LogHeader();
extern void     LogTime();
extern void     LogTrailer();
extern void     lprintf(char *com, ...);
extern void     lprint_only(char *com, ...);
extern int      NestedLevel();
extern Script  *NextScript();
extern Script  *NextScript();
extern void     normal_tty();
extern char   **NULLArgv();
extern void     OpenLog();
extern FILE    *OpenScriptFile();
extern void     ParseInit();
extern void     ProcessStatus();
extern void     PutAuxFunc();
extern float    rangauss();
extern void     ReallocateArgList();
extern void     RecordStartTime();
extern void     RemoveCleanup();
extern void     RemoveJob();
extern void     ResetErrors();
extern void     RestoreCursorPosition();
extern void     restore_tty();
extern void     SaneTerm();
extern void     SaveCursorPosition();
extern int      ScriptArgc();
extern char    *ScriptArgv();
extern int      ScriptDepth();
extern int      ScriptEnded();
extern int      ScrollRegion();
extern FILE    *SearchForExecutable();
extern FILE    *SearchForNonScript();
extern FILE    *SearchForScript();
extern void     SetAutoshell();
extern void     SetBatchMode();
extern void     SetDefaultPrompt();
extern void     SetPrompt();
extern void     SetScript();
extern void     SetSilent(); 
extern void     SetTtyMode();
extern void     SetUpFuncTable();
extern int      SetupInterp();
extern char    *sgets();
extern void     ShowFuncNames();
extern void     ShowHistory();
extern void     show_prompt();
extern void     Sleep();
extern void     Standout();
extern int      StatusActive();
extern void     StringToArgList();
extern char    *StripCR();
extern int      TermGoto();
extern void     terminal_setup();
extern void     TermParse();
extern char    *termstr();
extern void     tset();
extern int      ValidScript();
extern void     Warning();

#endif /* SHELL_FUNC_EXT_H */

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