Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)

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Accession:153355
"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. ... We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics. "
Reference:
1 . Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart motor neuron (HE);
Channel(s): I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Temporal Pattern Generation; Detailed Neuronal Models; Parameter sensitivity; Conductance distributions;
Implementer(s): Lamb, Damon [Damon.Lamb at neurology.ufl.edu];
Search NeuronDB for information about:  I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
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LambCalabrese2013
lgenesis-noX
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FMT1_func_ext.h
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user_struct.h
                            
/*
** $Id: shell_struct.h,v 1.3 2005/06/26 08:29:26 svitak Exp $
** $Log: shell_struct.h,v $
** Revision 1.3  2005/06/26 08:29:26  svitak
** Added comment regarding include directives in this file.
**
** Revision 1.2  2005/06/26 08:25:37  svitak
** Provided explicit types for untyped funtions. Fixed return statements to
** match return type.
**
** Revision 1.1.1.1  2005/06/14 04:38:34  svitak
** Import from snapshot of CalTech CVS tree of June 8, 2005
**
** Revision 1.3  2001/04/25 17:17:00  mhucka
** Misc. small changes to improve portability and address compiler warnings.
**
** Revision 1.2  2000/06/19 06:06:26  mhucka
** The Script structure and the handling of scripts had this bogosity in which
** FILE pointers were being cast to char * and back again.  Why on earth
** didn't the authors just keep a separate pointer in the Script structure for
** FILE pointers, instead of shoehorning the pointers into the .ptr char *
** field?  Anyway, for better robustness and portability, I reimplemented this
** part using two separate pointers.
**
** Revision 1.1  1992/12/11 19:04:55  dhb
** Initial revision
**
*/

/*
** This file is processed by the code_sym program, a code-generation
** utility of genesis. It requires definitions for FILE from <stdio.h>
** and PFD from "header.h". These files should be included before this file.
**
** Do not include any other files within this file!
*/

#ifndef SHELL_STRUCT_H
#define SHELL_STRUCT_H

#ifndef PFI_DEFINED
#define PFI_DEFINED
typedef int	(*PFI)();
#endif

typedef struct _EscapeCommand {
    char	*escseq;
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    char	**argv;
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} EscapeCommand;

typedef struct script_type {
    char	*ptr;
    char	*current;
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    int		argc;
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} Script;

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	PFI	adr;
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typedef struct {
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} Info;

typedef struct {
    PFI		function;
    int		count;
    int		priority;
} Job; 


#endif

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