Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)

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Accession:154096
"... As cells die and synapses lose their drive, remaining cells suffer an initial decrease in activity. Neuronal homeostatic synaptic scaling then provides a feedback mechanism to restore activity. ... The scaling mechanism increases the firing rates of remaining cells in the network to compensate for decreases in network activity. However, this effect can itself become a pathology, ... Here, we present a mechanistic explanation of how directed brain stimulation might be expected to slow AD progression based on computational simulations in a 470-neuron biomimetic model of a neocortical column. ... "
Reference:
1 . Rowan MS, Neymotin SA, Lytton WW (2014) Electrostimulation to reduce synaptic scaling driven progression of Alzheimer's disease. Front Comput Neurosci 8:39 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 pyramidal corticothalamic L6 cell; Neocortex V1 pyramidal intratelencephalic L2-5 cell; Neocortex V1 interneuron basket PV cell; Neocortex fast spiking (FS) interneuron; Neocortex spiny stellate cell; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Python;
Model Concept(s): Long-term Synaptic Plasticity; Aging/Alzheimer`s; Deep brain stimulation; Homeostasis;
Implementer(s): Lytton, William [billl at neurosim.downstate.edu]; Neymotin, Sam [samn at neurosim.downstate.edu]; Rowan, Mark [m.s.rowan at cs.bham.ac.uk];
Search NeuronDB for information about:  Neocortex V1 pyramidal corticothalamic L6 cell; Neocortex V1 pyramidal intratelencephalic L2-5 cell; Neocortex V1 interneuron basket PV cell; GabaA; AMPA; NMDA; Gaba; Glutamate;
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RowanEtAl2014
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// $Id: default.hoc,v 1.5 2003/07/08 16:16:52 billl Exp $
/* This file contains various global defaults for hoc

** Users should not edit nrnoc.hoc or default.hoc.  Any local 
changes to these files should be made in local.hoc.
----------------------------------------------------------------*/

/*------------------------------------------------------------
Object defaults
------------------------------------------------------------*/

/*** Define a "nil" object ***/
objectvar nil

/*------------------------------------------------------------
String defaults
------------------------------------------------------------*/

/*** "Section" is used if errors are found in the initializiations ***/
strdef section

/*** Misc defines used by graphic routines ***/
temp_string_ = "t"
tempvar = 0

/*------------------------------------------------------------
Simulation defaults
------------------------------------------------------------*/

                        /* To be consistent w/the nmodl values */
FARADAY = 96520.        /* Hoc default = 96484.56 */
PI      = 3.14159       /* Hoc default = 3.1415927 */

                        /* 0=off, 1=on */
print_flag  = 0         /* Write to output file */
graph_flag  = 1         /* Plot output */
iv_flag     = 1         /* Using Interviews plotting */
batch_flag  = 0         /* Using batch_run() */
compress_flag = 0       /* Compress output file when saved */
stoprun     = 0         /* 0=running, 1=stopped */
iv_loaded   = 0         /* Load initial iv stuff on once */

init_seed   = 830529
run_seed    = 680612

t           = 0         /* msec */
dt          = .01       /* msec */
tstop       = 100       /* msec */
printStep   = 0.1       /* msec */
plotStep    = 0.1       /* msec */
flushStep   = 0.1       /* msec */
eventStep   = 50        /* Number of nstep's before a doEvent */

secondorder = 0

celsius     = 6.3       /* degC */

v_init      = -70       /* (mV) */
global_ra   = 200       /* (ohm-cm) specific axial resisitivity */

/*** Ion parameters ***/
ca_init     = 50e-6     /* mM */
na_init     = 10        /* mM */
k_init      = 54.4      /* mM */


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