Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)

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Accession:154096
"... As cells die and synapses lose their drive, remaining cells suffer an initial decrease in activity. Neuronal homeostatic synaptic scaling then provides a feedback mechanism to restore activity. ... The scaling mechanism increases the firing rates of remaining cells in the network to compensate for decreases in network activity. However, this effect can itself become a pathology, ... Here, we present a mechanistic explanation of how directed brain stimulation might be expected to slow AD progression based on computational simulations in a 470-neuron biomimetic model of a neocortical column. ... "
Reference:
1 . Rowan MS, Neymotin SA, Lytton WW (2014) Electrostimulation to reduce synaptic scaling driven progression of Alzheimer's disease. Front Comput Neurosci 8:39 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 pyramidal corticothalamic L6 cell; Neocortex V1 pyramidal intratelencephalic L2-5 cell; Neocortex V1 interneuron basket PV cell; Neocortex fast spiking (FS) interneuron; Neocortex spiny stellate cell; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Python;
Model Concept(s): Long-term Synaptic Plasticity; Aging/Alzheimer`s; Deep brain stimulation; Homeostasis;
Implementer(s): Lytton, William [billl at neurosim.downstate.edu]; Neymotin, Sam [samn at neurosim.downstate.edu]; Rowan, Mark [m.s.rowan at cs.bham.ac.uk];
Search NeuronDB for information about:  Neocortex V1 pyramidal corticothalamic L6 cell; Neocortex V1 pyramidal intratelencephalic L2-5 cell; Neocortex V1 interneuron basket PV cell; GabaA; AMPA; NMDA; Gaba; Glutamate;
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RowanEtAl2014
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// $Id: bpf.h,v 1.6 2010/04/22 02:41:48 samn Exp $ 
#include <string.h>

#ifndef BPF_IN
#define BPF_IN

#define MyStdErr stderr

// #define WINDOWS_MACHINE
#define UNIX_MACHINE


// These are the Labels that are searched for in the Header file
#define HEADER_BEGIN_LABEL                              "%%BEGIN_HEADER"
#define HEADER_END_LABEL                                "%%END_HEADER"
#define SECTION_BEGIN_LABEL                             "%%BEGIN"
#define SECTION_END_LABEL                               "%%END"
#define COMMENT                                         "//"
#define TYPE_PREFIX                                     '.'

#define BPF_HEADER_TYPE                                 "BRAIN_POTENTIAL_FILE"
#define ACX                                             1
#define AXONA                                           2

#define SECTION_GENERAL_INFORMATION                     "GENERAL_INFORMATION"
#define SECTION_DATABASE_INFORMATION                    "DATABASE_INFORMATION"
#define SECTION_SETUP_INFORMATION                       "SETUP_INFORMATION"
#define SECTION_RECORD_FORMAT_INFORMATION               "RECORD_FORMAT_INFORMATION"

#define MAX_NUMBER_OF_BPF_CHANNELS	                64
#define MAX_NUMBER_BPF_FORMAT_PARAMETERS                256
#define MAX_BPF_RECORD_TYPES                            256
#define NUMBER_OF_BPF_TETRODE_CHANNELS	                4
#define NUMBER_OF_BPF_TETRODE_SAMPLES	                64
#define NUMBER_OF_BPF_EEG_CHANNELS                      2
#define NUMBER_OF_BPF_EEG_SAMPLES                       1000

#define DATE_LABEL                                      "%Date."
#define TIME_LABEL                                      "%Time."
#define SAMPLE_FORMAT_LABEL                             "%Sample."
#define NUMBER_OF_SAMPLING_TYPES                        "%NumberOfSamplingTypes."
#define SPIKE_SAMPLING_FREQUENCY                        "%SpikeSamplingFrequency."
#define EEG_SAMPLING_FREQUENCY                          "%EegSamplingFrequency."
#define NUMBER_OF_CHANNEL_TYPES                         "%NumberOfChannelTypes."
#define NUMBER_OF_EEG_CHANNELS                          "%NumberOfEegChannels."
#define LIST_OF_EEG_CHANNELS                            "%ListOfEegChannels."
#define NUMBER_OF_SYNC_CHANNELS                         "%NumberOfSyncChannels."
#define LIST_OF_SYNC_CHANNELS                           "%ListOfSyncChannels."
#define NUMBER_OF_SINGLE_CHANNELS                       "%NumberOfSingleChannels."
#define LIST_OF_SINGLE_CHANNELS                         "%ListOfSingleChannels."
#define NUMBER_OF_STEREO_CHANNELS                       "%NumberOfStereoChannels."
#define LIST_OF_STEREO_CHANNELS                         "%ListOfStereoChannels."
#define NUMBER_OF_TETRODE_CHANNELS                      "%NumberOfTetrodeChannels."
#define LIST_OF_TETRODE_CHANNELS                        "%ListOfTetrodeChannels."
#define ROOM_POSITIONS				        "%RoomPositions."
#define ARENA_POSITIONS				        "%ArenaPositions."
#define LIST_OF_GAINS                                   "%ListOfGains."
#define CHANNEL_LABEL					"%ChannelLabel."
#define ACQUISITION_SYSTEM_LABEL                        "%AcquisitionSystem."
#define KEY_EVENTS				        "%KeyEvents."

#define RECORD_ID_ENCODING                              1
#define ASCII_STARTING_MARK                             "("
#define ASCII_TERMINATING_MARK                          ")"
#define BINARY_STARTING_MARK                            "('"
#define BINARY_TERMINATING_MARK                         "')"

#define EEG_BPF_REC_TYPE                                'E'
#define SINGLE_BPF_REC_TYPE                             'U'
#define STEREO_BPF_REC_TYPE                             'S'
#define TETRODE_BPF_REC_TYPE                            'T'
#define SYNC_BPF_REC_TYPE                               'Y'
#define ROOM_POSITION_BPF_REC_TYPE                      'R'
#define ARENA_POSITION_BPF_REC_TYPE                     'A'
#define EVOKED_POTENTIAL_BPF_REC_TYPE                   'V'
#define KEY_EVENT_BPF_REC_TYPE                          'K'
#define INPUT_EVENT_BPF_REC_TYPE                        'I'
#define OUTPUT_EVENT_BPF_REC_TYPE                       'O'

#define EEG_BPF_REC_SIZE                                4005
#define SINGLE_BPF_REC_SIZE                             71
#define STEREO_BPF_REC_SIZE                             135
#define TETRODE_BPF_REC_SIZE                         	519
#define TETRODE_BPF_REC_INFO_SIZE                     (TETRODE_BPF_REC_SIZE - (2 * NUMBER_OF_BPF_TETRODE_CHANNELS * NUMBER_OF_BPF_TETRODE_SAMPLES)) 
#define EEG_BPF_REC_INFO_SIZE                           (EEG_BPF_REC_SIZE - (2 * NUMBER_OF_BPF_EEG_CHANNELS * NUMBER_OF_BPF_EEG_SAMPLES))

#define EVOKED_POTENTIAL_BPF_REC_SIZE                   8199
#define SYNC_BPF_REC_SIZE                               2005
#define ROOM_POSITION_BPF_REC_SIZE                      9
#define ARENA_POSITION_BPF_REC_SIZE                     9
#define KEY_EVENT_BPF_REC_SIZE                          6
#define MAX_BPF_REC_SIZE				(32005)  // 16 ch EEG

#define INPUT_EVENT_BPF_REC_SIZE                        7
#define OUTPUT_EVENT_BPF_REC_SIZE                       7

#define EEG_ID                                          "%EegIdentifier."
#define EEG_RECORD_FORMAT                               "%EegRecordFormat."
#define SYNC_ID                                         "%SyncIdentifier."
#define SYNC_RECORD_FORMAT                              "%SyncRecordFormat."
#define SINGLE_ID                                       "%SingleIdentifier."
#define SINGLE_RECORD_FORMAT                            "%SingleRecordFormat."
#define STEREO_ID                                       "%StereoIdentifier."
#define STEREO_RECORD_FORMAT                            "%StereoRecordFormat."
#define TETRODE_ID                                      "%TetrodeIdentifier."
#define TETRODE_RECORD_FORMAT                           "%TetrodeRecordFormat."
#define ROOM_POSITION_ID                                "%RoomPositionIdentifier."
#define ROOM_POSITION_RECORD_FORMAT                     "%RoomPositionRecordFormat."
#define ARENA_POSITION_ID                               "%ArenaPositionIdentifier."
#define ARENA_POSITION_RECORD_FORMAT                    "%ArenaPositionRecordFormat."
#define KEY_EVENT_ID                                    "%KeyEventIdentifier."
#define KEY_EVENT_RECORD_FORMAT                         "%KeyEventRecordFormat."
#define INPUT_EVENT_ID                                  "%InputEventIdentifier."
#define INPUT_EVENT_RECORD_FORMAT                       "%InputEventRecordFormat."
#define OUTPUT_EVENT_ID                                 "%OutputEventIdentifier."
#define OUTPUT_EVENT_RECORD_FORMAT                      "%OutputEventRecordFormat."

#define	BPF_RECORD_TIME_STAMP_OFFSET				1
#define BPF_RECORD_PROBE_OFFSET					5
#define BPF_SPK_REC_CLUST_OFFSET				6
#define	BPF_KEY_EVENT_REC_OFFSET       				5 
#define BPF_SYNC_PROBE						31
#define	BPF_POS_REC_X_OFFSET       				5 
#define BPF_POS_REC_Y_OFFSET 					6 
#define BPF_POS_REC_ANG_OFFSET					7
#define EEG_BPF_REC_DATA_SIZE					2000
#define EEG_BPF_REC_ID_SIZE					5

#define SAMPLES_PER_EVOKED_POTENTIAL			1024
#define CLICKS_PER_SEC                                  10000
#define CLICKS_PER_MIN                                  (CLICKS_PER_SEC * 60)
#endif


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