Understanding how fast activating K+ channels promote bursting in pituitary cells (Vo et al 2014)


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Accession:154955
"... Experimental observations have shown ... that fast-activating voltage- and calcium-dependent potassium (BK) current tends to promote bursting in pituitary cells. This burst promoting effect requires fast activation of the BK current, otherwise it is inhibitory to bursting. In this work, we analyze a pituitary cell model in order to answer the question of why the BK activation must be fast to promote bursting. ..."
Reference:
1 . Vo T, Tabak J, Bertram R, Wechselberger M (2014) A geometric understanding of how fast activating potassium channels promote bursting in pituitary cells. J Comput Neurosci 36:259-78 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Pituitary cell;
Channel(s): I K; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP (web link to model);
Model Concept(s): Bursting; Oscillations; Bifurcation;
Implementer(s):
Search NeuronDB for information about:  I K; I K,Ca; I Calcium;
(located via links below)
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