" ...To study
the relationship between the (Ca2+ channel) T-distribution and several (LGN interneuron) IN response properties, we here
run a series of simulations where we vary the T-distribution in a multicompartmental IN
model with a realistic morphology. We find that the somatic response to somatic
current injection is facilitated by a high T-channel density in the soma-region.
Conversely, a high T-channel density in the distal dendritic region is found to facilitate
dendritic signalling in both the outward direction (increases the response in
distal dendrites to somatic input) and the inward direction (the soma responds stronger
to distal synaptic input). ..."
Allken V, Chepkoech JL, Einevoll GT, Halnes G (2014) The subcellular distribution of T-type Ca2+ channels in interneurons of the lateral geniculate nucleus. PLoS One 9:e107780 [PubMed]