Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; NMDA; Gaba;
/
striatalnetwork
Conditions
No_Gaps
FScell
channels
AddSynapticChannels.g *
AddSynapticChannels.g~ *
cellMorphology.g *
errorHandler.g *
FScell.g *
FScell.g~ *
FScell.p *
FScell.p~ *
FScellSyn.g *
FScellSyn.g~ *
include_channels.g *
include_channels.g~ *
proto.g *
proto.g~ *
SynParams.g *
SynParams.g~ *
                            
//FScell.p cell parameter file 
// co-ordinate mode
*relative
*cartesian
*asymmetric
*lambda_warn

// specifying constants, SI units
// Plenz D, Aertsen A. Neuroscience. 1996 Feb;70(4):861-91
// J Neurosci 1994,14:4613-4638 says Cm=0.007-0.008, Rm 120-200kOhm*cm^2 ???
//*set_compt_param RM 0.95 //ohm*m^2 =10 kohm*cm^2
*set_compt_param RM 2 //ohm*m^2 //Avrama decreased from 3 to 2 fix timeconstants
//*set_compt_param CM 0.01 //farads/m^2
*set_compt_param CM 0.007 //farads/m^2
//*set_compt_param RA 2  //ohm*m = 100 ohm*cm
*set_compt_param RA 3  //ohm*m
*set_compt_param EREST_ACT -0.063 //?? relative to zero??

// ELEAK is -0.063 without dopamin and -0.061 with dopamine
*set_compt_param ELEAK -0.063  // resting, Volts, was -65mV before



*start_cell /library/tert_dend
// x, y, z or x=length if y and z=0
   tert_dend   none        30    0    0    0.5 
   tert_dend2  .           30    0    0    0.5 
   tert_dend3  .           30    0    0    0.5 
   tert_dend4  .           30    0    0    0.5
   tert_dend5  .           30    0    0    0.5 
   tert_dend6  .           30    0    0    0.5 
   tert_dend7  .           30    0    0    0.5 
   tert_dend8  .           30    0    0    0.5 

// make distal dend with 8 compartments a prototype
*makeproto /library/tert_dend

*start_cell /library/sec_dend
   sec_dend   none   37    0    0    0.75 A_channel 00
   sec_dend2  .      37    0    0    0.75 A_channel 00
   sec_dend3  .      37    0    0    0.75 A_channel 00
   sec_dend4  .      37    0    0    0.75 A_channel 00

*makeproto /library/sec_dend

*start_cell /library/prim_dend
   prim_dend  none  45  0  0  1 A_channel 90  Na_channel 0 K3132_channel 0
   prim_dend2 .  45  0  0  1 A_channel 90  Na_channel 0 K3132_channel 0
  
*makeproto /library/prim_dend

*start_cell 
   soma   none  20  0  0 15 Na_channel 1149 K3132_channel 582 A_channel 333 K13_channel 1.46


*compt /library/prim_dend
primdend1   soma      45    0    0    1 
primdend2   soma      45    0    0    1 
primdend3   soma      45    0    0    1 
 
*compt /library/sec_dend
   secdend1  primdend1/prim_dend2 37  0  0  0.75
   secdend2   primdend1/prim_dend2 37  0  0  0.75
   secdend3   primdend2/prim_dend2 37  0  0  0.75 
   secdend4   primdend2/prim_dend2 37  0  0  0.75
   secdend5  primdend3/prim_dend2 37  0  0  0.75
   secdend6  primdend3/prim_dend2 37  0  0  0.75


*compt /library/tert_dend
tertdend1  secdend1/sec_dend4 30    0  0  0.5 
tertdend2  secdend1/sec_dend4 30    0  0  0.5 
tertdend3  secdend2/sec_dend4 30    0  0  0.5 
tertdend4  secdend2/sec_dend4 30    0  0  0.5 
tertdend5  secdend3/sec_dend4 30    0  0  0.5 
tertdend6  secdend3/sec_dend4 30    0  0  0.5 
tertdend7  secdend4/sec_dend4 30    0  0  0.5
tertdend8  secdend4/sec_dend4 30    0  0  0.5
tertdend9  secdend5/sec_dend4 30    0  0  0.5 
tertdend10  secdend5/sec_dend4 30    0  0  0.5 
tertdend11  secdend6/sec_dend4 30    0  0  0.5
tertdend12  secdend6/sec_dend4 30    0  0  0.5


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