Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

 Download zip file 
Help downloading and running models
Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; NMDA; Gaba;
/
striatalnetwork
MScell
channels
unusedChannels
AddCaSpines.g *
addchans.g *
addchans.g~ *
addinput.g *
addoutput.g *
addoutput.g~
addoutput_old.g *
AddSynapticChannels.g *
connectCaChannels.g *
DA_files.txt *
globals.g
globals.g~
globals_old.g
globalsCaComp.g *
include_channels.g *
MScell.g~
MScell.p *
MScell_D1.g *
MScell_D1.g~
MScell_D1_old.g
MScell_D2.g *
MScell_D2.g~
MScell_D2_old.g
MScell08.p *
MScell08CM3_D1.p *
MScell08CM3_D2.p *
MScell08CM3_old.p
MScellSpine.g *
MScellSpineCtx.g *
MScellSpineTh.g *
MScellSyn.g~ *
MScellSyn_D1.g *
MScellSyn_D2.g *
parametersA.g~
parametersA_D1.g *
parametersA_D2.g *
parametersB.g *
parametersC.g *
parametersD.g *
proto.g *
proto.g~
spines.g *
SynParams.g~
SynParams_D1.g
SynParams_D2.g
SynParamsCtx.g *
SynParamsTh.g *
                            
//***************************		MS Model, Version 5.0	**********************
//*************************** 	      MScell.p 			**********************
//			Tom Sheehan tsheeha2@gmu.edu	thsheeha@vt.edu	703-538-836
//*****************************************************************************

*relative
*cartesian
*asymmetric
*lambda_warn

*set_global ELEAK -0.070
//*set_global RA 1.0 
//*set_global RM 8.695652
*set_global RM 1.8
//*set_global CM 0.010 
//change Cm to account for no spines - make 3x higher?
*set_global CM 0.03  
*set_global EREST_ACT -0.085

*start_cell /library/tert_dend
tert_dend none 35.927 0 0 0.80
tert_dend2 . 35.927 0 0 0.80 
tert_dend3 . 35.927 0 0 0.80
tert_dend4 . 35.927 0 0 0.80
tert_dend5 . 35.927 0 0 0.80 
tert_dend6 . 35.927 0 0 0.80
tert_dend7 . 35.927 0 0 0.80 
tert_dend8 . 35.927 0 0 0.80
tert_dend9 . 35.927 0 0 0.80
tert_dend10 . 35.927 0 0 0.80
tert_dend11 . 35.927 0 0 0.80
*makeproto /library/tert_dend

*start_cell /library/sec_dend

sec_dend none 24.230 0 0 1.100
*makeproto /library/sec_dend

*start_cell /library/prim_dend

prim_dend none 20.000 0 0 2.250
*makeproto /library/prim_dend

*start_cell
*spherical
*set_compt_param RA 4
soma none 16.000 0 0 16.000

*cylindrical

*set_compt_param RA 4
*compt /library/prim_dend
primdend1 soma 20 0 0 2.25
primdend2 soma 20 0 0 2.25
primdend3 soma 20 0 0 2.25
primdend4 soma 20 0 0 2.25

*set_compt_param RA 4
*compt /library/sec_dend
secdend1 primdend1 24.23 0 0 1.1
secdend2 primdend1 24.23 0 0 1.1
secdend3 primdend2 24.23 0 0 1.1
secdend4 primdend2 24.23 0 0 1.1
secdend5 primdend3 24.23 0 0 1.1
secdend6 primdend3 24.23 0 0 1.1
secdend7 primdend4 24.23 0 0 1.1
secdend8 primdend4 24.23 0 0 1.1

*set_compt_param        RA      2
*compt /library/tert_dend
tertdend1 secdend1 35.927  0  0  0.8
tertdend2 secdend1 35.927  0  0  0.8
tertdend3 secdend2 35.927  0  0  0.8
tertdend4 secdend2 35.927  0  0  0.8
tertdend5 secdend3 35.927  0  0  0.8
tertdend6 secdend3 35.927  0  0  0.8
tertdend7 secdend4 35.927  0  0  0.8
tertdend8 secdend4 35.927  0  0  0.8
tertdend9 secdend5 35.927  0  0  0.8
tertdend10 secdend5 35.927  0  0  0.8
tertdend11 secdend6 35.927  0  0  0.8
tertdend12 secdend6 35.927  0  0  0.8
tertdend13 secdend7 35.927  0  0  0.8
tertdend14 secdend7 35.927  0  0  0.8
tertdend15 secdend8 35.927  0  0  0.8
tertdend16 secdend8 35.927  0  0  0.8

Loading data, please wait...