Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; NMDA; Gaba;
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striatalnetwork
MScell
channels
unusedChannels
AddCaSpines.g *
addchans.g *
addchans.g~ *
addinput.g *
addoutput.g *
addoutput.g~
addoutput_old.g *
AddSynapticChannels.g *
connectCaChannels.g *
DA_files.txt *
globals.g
globals.g~
globals_old.g
globalsCaComp.g *
include_channels.g *
MScell.g~
MScell.p *
MScell_D1.g *
MScell_D1.g~
MScell_D1_old.g
MScell_D2.g *
MScell_D2.g~
MScell_D2_old.g
MScell08.p *
MScell08CM3_D1.p *
MScell08CM3_D2.p *
MScell08CM3_old.p
MScellSpine.g *
MScellSpineCtx.g *
MScellSpineTh.g *
MScellSyn.g~ *
MScellSyn_D1.g *
MScellSyn_D2.g *
parametersA.g~
parametersA_D1.g *
parametersA_D2.g *
parametersB.g *
parametersC.g *
parametersD.g *
proto.g *
proto.g~
spines.g *
SynParams.g~
SynParams_D1.g
SynParams_D2.g
SynParamsCtx.g *
SynParamsTh.g *
                            
//addoutput.g
	// function for saving parameter in ascii file.  
	//function is made and called in this file
	
//make function 

function sav_disk_asc(diskpath,srcpath,field)
    create asc_file /output/{diskpath}
    setfield /output/{diskpath}   flush 1  leave_open 1 append 1 \
          float_format %0.6g
    useclock /output/{diskpath} 0
    setfield /output/{diskpath} filename output/{diskpath}
    addmsg {srcpath} /output/{diskpath}  SAVE {field}
    call /output/{diskpath} OUT_OPEN
    call /output/{diskpath} OUT_WRITE "time #1" //header
    echo {diskpath}
end
		
		
		
//call function
	
	/*******************save soma information****************************************************
		//sav_disk_asc somaVm{subunit}{stimtype} {cellpath}/soma Vm
	*******************************************************************************************/
	
	/*******************save secondary dendrite parameters**************************************
		//sav_disk_asc dendCa{subunit}{stimtype} {cellpath}/secdend3/{CalciumBuffer_3} Ca  
		//sav_disk_asc NMDACa{subunit}{stimtype} {cellpath}/secdend3/spine_1/head/buffer_NMDA Ca
		//sav_disk_asc spineCa{subunit}{stimtype} {cellpath}/secdend3/spine_1/head/SpineCa Ca
		//sav_disk_asc LspineCa{subunit}{stimtype} {cellpath}/secdend3/spine_1/head/SpineCaL Ca
		//sav_disk_asc Ikblock{subunit}{stimtype} {cellpath}/secdend3/spine_1/head/{subunit}/block Ik
		//sav_disk_asc spineVm{subunit}{stimtype} {cellpath}/secdend3/spine_1/head Vm
	*******************************************************************************************/
 
	/******************save tertiary dendrite information****************************************
		sav_disk_asc dendCa{subunit}{stimtype}3 {cellpath}/tertdend3/{CalciumBuffer_3} Ca
	//	sav_disk_asc spineCa{subunit}{stimtype}3 {cellpath}/tertdend3/tert_dend5/spine_1/head/buffer_NMDA
	//	sav_disk_asc Ikblock{subunit}{stimtype}3 {cellpath}/tertdend3/tert_dend5/spine_1/head/{subunit}/block Ik Ca
	//	sav_disk_asc spineVm{subunit}{stimtype}3 {cellpath}/tertdend3/tert_dend5/spine_1/head Vm
	//	sav_disk_asc IkAMPA{stitype}3 {cellpath}/tertdend3/tert_dend5/spine_1/head/AMPA Ik
	//	sav_disk_asc IkAMPA{stitype}2 {cellpath}/tertdend3/tert_dend5/spine_1/head/AMPA Ik
	*********************************************************************************************/
 
 // this function allows you to put several columns in the same file and name them using the call function series below it.  
 function add_output_sec 
     int ctr	
     str net_n="/SPnetwork/SPcell"
     create asc_file /output/plot_out
	setfield /output/plot_out   flush 1  leave_open 1 append 1 \
          float_format %0.6g
    useclock /output/plot_out 1
 for(ctr = 0; ctr < 10; ctr = {ctr + 1})
    addmsg {net_n}[{ctr}]/secdend3/{CA_BUFF_3} /output/plot_out  SAVE Ca  //not hooked up?
    addmsg {net_n}[{ctr}]/soma /output/plot_out  SAVE Vm
    addmsg {net_n}[{ctr}]/tertdend1/{CA_BUFF_3} /output/plot_out  SAVE Ca  //not hooked up?
    //addmsg {cellpath}/secdend3/spine_1/head/buffer_NMDA /output/plot_out  SAVE Ca
end
    //addmsg {cellpath}/secdend3/tert_dend5/spine_1/head/{subunit}/block /output/plot_out  SAVE Ik
    //addmsg {cellpath}/secdend3/spine_1/head/spineCaL /output/plot_out  SAVE Ca
	//addmsg {cellpath}/secdend3/spine_1/head/spineCa /output/plot_out  SAVE Ca
    //addmsg {cellpath}/secdend3/spine_1/head /output/plot_out SAVE Vm
	
	call /output/plot_out OUT_OPEN
	call /output/plot_out OUT_WRITE "time  CaDend  	SomaVm" //header
end
   
function add_output_tert
	create asc_file /output/plot_out
	setfield /output/plot_out   flush 1  leave_open 1 append 1 \
          float_format %0.6g
    useclock /output/plot_out 1
    addmsg {cellpath}/tertdend3/tert_dend3/{CA_BUFF_3} /output/plot_out  SAVE Ca  //not hooked up?
    addmsg {cellpath}/tertdend3/tert_dend3/spine_1/head/buffer_NMDA /output/plot_out  SAVE Ca
    //addmsg {cellpath}/tertdend3/tert_dend3/tert_dend5/spine_1/head/{subunit}/block /output/plot_out  SAVE Ik
    addmsg {cellpath}/tertdend3/tert_dend3/spine_1/head/spineCaL /output/plot_out  SAVE Ca
	addmsg {cellpath}/tertdend3/tert_dend3/spine_1/head/spineCa /output/plot_out  SAVE Ca
    //addmsg {cellpath}/tertdend3/tert_dend3/spine_1/head	/output/plot_out SAVE Vm
	addmsg {cellpath}/soma /output/plot_out  SAVE Vm
	call /output/plot_out OUT_OPEN
	call /output/plot_out OUT_WRITE "time  CaDend CaNMDA   SpineLtype	SpineCa	SomaVm" //header
end

/*this part goes in a sim file and calls the add_ouput file above.    
	str diskpath 
	add_output_sec
	// open file for 1AP, then run sim
	stimtype="1APnegsec"
	diskpath=(subunit)@(stimtype)@".txt"
	echo {diskpath}
	setfield /output/plot_out filename output/{diskpath}
		call /output/plot_out OUT_OPEN
		call /output/plot_out OUT_WRITE "time	-20" 
	reset
	include 1APnegsec.g
*/
   
   
   

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