Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; NMDA; Gaba;
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striatalnetwork
MScell
channels
unusedChannels
AddCaSpines.g *
addchans.g *
addchans.g~ *
addinput.g *
addoutput.g *
addoutput.g~
addoutput_old.g *
AddSynapticChannels.g *
connectCaChannels.g *
DA_files.txt *
globals.g
globals.g~
globals_old.g
globalsCaComp.g *
include_channels.g *
MScell.g~
MScell.p *
MScell_D1.g *
MScell_D1.g~
MScell_D1_old.g
MScell_D2.g *
MScell_D2.g~
MScell_D2_old.g
MScell08.p *
MScell08CM3_D1.p *
MScell08CM3_D2.p *
MScell08CM3_old.p
MScellSpine.g *
MScellSpineCtx.g *
MScellSpineTh.g *
MScellSyn.g~ *
MScellSyn_D1.g *
MScellSyn_D2.g *
parametersA.g~
parametersA_D1.g *
parametersA_D2.g *
parametersB.g *
parametersC.g *
parametersD.g *
proto.g *
proto.g~
spines.g *
SynParams.g~
SynParams_D1.g
SynParams_D2.g
SynParamsCtx.g *
SynParamsTh.g *
                            
// genesis

float useAMPANMDAGHKchannels= 0  // we do not use GHK project for NMDA/AMPA

setclock 0 5e-6 //was 5e-6
        // Simulation time step (Second)       
setclock 1 2e-5        //  time step for ascii output
//setclock 1 1e-4 // time step for graphic output


// parameters for NMDA subunits


// NR2A
str	    subunit = "NR2A"
float   EkNMDA   = 0
float	Kmg       = 3.57
float	NMDAtau2      = (112e-3)/2 	// 50e-3 changed to 112 to include 25%NR2B NR2A average from (Vicini et al., 1998 figure 1B)
float	NMDAgmax      = 0.39e-9      //  NR2A and B from (Moyner et al., 1994 figure 7) //0.94e-9 - NMDA
int ghk_yesno=0

str NMDAname = {subunit}

//for saving info on distal or proximal dendrites or massed and spaced. formula typeof dend, # of spines.



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