Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; NMDA; Gaba;
/
striatalnetwork
MScell
channels
unusedChannels
AddCaSpines.g *
addchans.g *
addchans.g~ *
addinput.g *
addoutput.g *
addoutput.g~
addoutput_old.g *
AddSynapticChannels.g *
connectCaChannels.g *
DA_files.txt *
globals.g
globals.g~
globals_old.g
globalsCaComp.g *
include_channels.g *
MScell.g~
MScell.p *
MScell_D1.g *
MScell_D1.g~
MScell_D1_old.g
MScell_D2.g *
MScell_D2.g~
MScell_D2_old.g
MScell08.p *
MScell08CM3_D1.p *
MScell08CM3_D2.p *
MScell08CM3_old.p
MScellSpine.g *
MScellSpineCtx.g *
MScellSpineTh.g *
MScellSyn.g~ *
MScellSyn_D1.g *
MScellSyn_D2.g *
parametersA.g~
parametersA_D1.g *
parametersA_D2.g *
parametersB.g *
parametersC.g *
parametersD.g *
proto.g *
proto.g~
spines.g *
SynParams.g~
SynParams_D1.g
SynParams_D2.g
SynParamsCtx.g *
SynParamsTh.g *
                            
//genesis

/***************************		MS Model, Version 5.12	**********************
**************************** 	      	proto.g 				**********************
Tom Sheehan tsheeha2@gmu.edu	thsheeha@vt.edu	703-538-8361
*******************************************************************************
	proto.g contains one primary routine:  
		make_prototypes
 	and two local routines 
		make_cylind_compartment
		make_spines - this one needs much work
	these are used by the primary and are not intended for external calls
	The primary function, make_prototypes is called exactly once by MSsim.g
AB: removed CaNNOINACT_channel and CaL12NOINACT_channel by combining with inactivating channels
AB: deleted CaQ because no evidence for such in SP, and doesn't contribute much anyway
AB: no longer making naP in the library since it is not used, and has been moved to a different directory
******************************************************************************/

include MScell/include_channels.g		// required for calls in make_protypes

//************************ Begin Local Subroutines ****************************

	//********************* Begin function make_cylind_compartment *************
	function make_cylind_compartment
		if (!{exists compartment})
			echo "COMPARTMENT DID NOT EXIST PRIOR TO CALL TO:"
			echo 			"make_cylind_compartment"
			create	compartment compartment
                        addfield compartment position   // add a new field "postion" to store distance to soma
		end

	setfield compartment 		\ 
     		Em         {ELEAK} 	\
      	        initVm     {EREST_ACT} 	\
		inject		0.0 	\
      	        position    0.0
	end
	//************************ End function make_cylind_compartment ************

	//**************************************************************************

//************************ End Local Subroutines ******************************
//*****************************************************************************

//************** Begin function make_prototypes (primary routine) *************

function make_prototypes

  	create neutral /library
  	disable /library
	pushe /library

        make_cylind_compartment

	//********************* create non-synaptic channels in library ************************
       //voltage dependent Na and K channels
 	make_NaF_channel_D1
        make_NaF_channel_D2 	
//	make_NaP_channel	
	make_KAf_channel		
	make_KAs_channel	
	make_KIR_channel	
	make_K_DR_channel  

       //voltage dependent Ca channels
 	create_CaL12 
	create_CaL13_D1	
        create_CaL13_D2
	create_CaN
//	create_CaQ
	create_CaR
 	create_CaT

       //Ca dependent K channels
	make_BKK_channel
	make_SK_channel
	//********************* End channels in library ************************

end
//************************ End function make_prototypes ***********************




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