Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

 Download zip file 
Help downloading and running models
Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; NMDA; Gaba;
// genesis
//SimNet.g  //Top level file used to run simulation

//include SimGlobals
//str net = {set_net "SP"}
include net
//include SP_output
include MScell/addoutput
include graphics

ce /
/*
create spikehistory Ctx.history
setfield Ctx.history ident_toggle 0 filename "Ctx.spikes" initialize 1 leave_open 1 flush 1
//addmsg /input/ Ctx.history SPIKESAVE 
*/

create spikehistory SPcell_D1.history
setfield SPcell_D1.history ident_toggle 0 filename "SPcell_D1.spikes" initialize 1 leave_open 1 flush 1

create spikehistory SPcell_D2.history
setfield SPcell_D2.history ident_toggle 0 filename "SPcell_D2.spikes" initialize 1 leave_open 1 flush 1
int g
for(g = 0; g < {getglobal numCells_SP}; g = {g + 1})
       if ({getfield /SPnetwork/SPcell[{g}]/soma D1} == 1)
       addmsg /SPnetwork/SPcell[{g}]/soma/spike SPcell_D1.history SPIKESAVE
       elif ({getfield /SPnetwork/SPcell[{g}]/soma D1} == 0) 
       addmsg /SPnetwork/SPcell[{g}]/soma/spike SPcell_D2.history SPIKESAVE
       end
end



create spikehistory FScell.history
setfield FScell.history ident_toggle 0 filename "FScell.spikes" initialize 1 leave_open 1 flush 1
addmsg /FSnetwork/FScell[]/soma/spike FScell.history SPIKESAVE


// make the control panel
//make_control

// make the graph to display soma Vm and pass messages to the graph
//make_Vmgraph

//make_netview
//makeOutput ""/{net}"network/"{net}"cell" "/output" 0.01
//make_inview
//add_output_sec 
//add_output_tert

int ctr
//add_output_both
/*
for (ctr=0; ctr<{getglobal numCells_SP}; ctr={ctr+1})

    addglobal str path_c_s{ctr}="Ca_soma_cell"{ctr}".txt"
    addglobal str path_c_t{ctr}="Ca_prim_cell"{ctr}".txt"
    addglobal str path_c_s{ctr}="Ca_sec_cell"{ctr}".txt"
    addglobal str path_c_t{ctr}="Ca_tert_cell"{ctr}".txt"
    addglobal str path_v_s{ctr}="Vm_sec_cell"{ctr}".txt"
    addglobal str path_v_t{ctr}="Vm_tert_cell"{ctr}".txt"
    addglobal str path_v_soma{ctr}="Vm_soma_cell"{ctr}".txt"
   // setfield /output/plot_out filename output/{diskpath}
    setfield /output/CaSomaOutCell{ctr} filename output/"Ca_soma_cell"{ctr}".txt"
    setfield /output/CaPrim2OutCell{ctr} filename output/"Ca_prim_cell"{ctr}".txt"
    setfield /output/CaSec6OutCell{ctr} filename output/"Ca_sec_cell"{ctr}".txt"
    setfield /output/CaTert12OutCell{ctr} filename output/"Ca_tert_cell"{ctr}".txt"
    setfield /output/VmSec6OutCell{ctr} filename output/"Vm_sec_cell"{ctr}".txt"  
    setfield /output/VmTert12OutCell{ctr} filename output/"Vm_tert_cell"{ctr}".txt"     
    setfield /output/VmSomaOutCell{ctr} filename output/"Vm_soma_cell"{ctr}".txt"  
 
end

check_input
for (ctr=0; ctr<{getglobal numCells_SP}; ctr={ctr+1})
    addglobal str in{ctr}="checkInput"{ctr}".txt"
    setfield /output/checkInput{ctr} filename output/"checkInput"{ctr}".txt"
end
*/
//colorize
reset
check
//include IF.g
//echo "Network of "{getglobal NX_{net}}" by "{getglobal NY_{net}}" cells with separations "{getglobal SEP_X_{net}}" by "{getglobal SEP_Y_{net}}
//makeOutput "/network/SPcell" {outputName} {vmOutDt}
//uncomment below 2 comments
reset       

step {maxTime} -t



//makeOutput "/network/SPcell" "OUT" 2
//clearOutput {outputName}

//quit


Loading data, please wait...