Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; NMDA; Gaba;
//genesis
//net.g 

/*
This file sets the netowork of SP cells up by calling the function that
sets up the SP-SP inhibitory network and calling the functions that connect
extrinsic input to the SP network.This file also has the include statements
for the file that prints out the connection of the SP-SP network. 
*/

include protospike
include nsynapses
include Net_parameters
include InputFromFile // External input
include net_conn
include net_func
include Utilities/connect_utility_pre
include Utilities/connect_utility_post

addglobal str cellPath_D1
setglobal cellPath_D1 "/library/SPcell_D1"
addglobal str cellPath_D2
setglobal cellPath_D2 "/library/SPcell_D2"
include MScell/MScellSyn_D1.g // Single SP neuron model with synaptic channels
makeMScellSyn "/library/SPcell_D1"  "MScell/MScell08CM3_D1.p"
make_spike {cellPath_D1}/soma
add_field {cellPath_D1}
setfield {cellPath_D1}/soma/spike thresh 0  abs_refract 0.004  output_amp 1
include MScell/MScellSyn_D2.g // Single SP neuron model with synaptic channels
makeMScellSyn  "/library/SPcell_D2" "MScell/MScell08CM3_D2.p"
make_spike {cellPath_D2}/soma
add_field {cellPath_D2}
setfield {cellPath_D2}/soma/spike thresh 0  abs_refract 0.004  output_amp 1
//D1-0 D2-1
make_net "SP" 0.5 //reads in function from net_func.g

addglobal str cellPath_FS
setglobal cellPath_FS "/library/FScell"
include FScell/FScellSyn.g // Single FS neuron model with synaptic channels
makeFScellSyn {getglobal cellPath_FS} "FScell/FScell.p"
make_spike {cellPath_FS}/soma
add_field {cellPath_FS}
setfield /library/FScell/soma/spike thresh 0  abs_refract 0.004  output_amp 1
make_net "FS" 0.5 //reads in function from net_func.g

//create heterogeneous cells by sending the network type, the channel to modulate & the % by which to do so across the network
//this function is described in net_func.g
//chan_mod "SP" "NR2A" 0.10
chan_mod "SP" "KAf" 0.10
chan_mod_FS "FS" "A" 0.5
//chan_mod "SP" "KIR" 0.2
//chan_mod "FS" "AMPA" 0.10
conn "FS" "FS" //reads in function from net_func.g
conn "SP" "SP"	//reads in function from net_func.g
//Utility files
pre "/SPnetwork/SPcell[]" "/SPnetwork/SPcell[]"
post "/SPnetwork/SPcell[]" "/SPnetwork/SPcell[]"
pre "/FSnetwork/FScell[]" "/SPnetwork/FScell[]"
post "/FSnetwork/FScell[]" "/SPnetwork/FScell[]"
//pre "/FSnetwork/FScell[]" "/FSnetwork/FScell[]"
//post "/FSnetwork/FScell[]" "/FSnetwork/FScell[]"
include Utilities/gaba_count

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