Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; NMDA; Gaba;
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striatalnetwork
Conditions
No_Gaps
FScell
channels
a_channel.g *
ampa_channel.g *
ampa_channel.g~ *
gaba_channel.g *
gaba_channel.g~ *
k13_channel.g *
k3132_channel.g *
na_channel.g *
synaptic_channel.g *
                            
/* 
 * interneuron simulation
 * Copyright (C) 2000 Rory Kirchner (rory@mail.csh.rit.edu)
 *
 * This program is free software; you can redistribute it and/or
 * modify it under the terms of the GNU General Public License
 * as published by the Free Software Foundation; either version 2
 * of the License, or (at your option) any later version.
 *
 * This program is distributed in the hope that it will be useful,
 * but WITHOUT ANY WARRANTY; without even the implied warranty of
 * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
 * GNU General Public License for more details.
 * 
 * You should have received a copy of the GNU General Public License
 * along with this program; if not, write to the Free Software
 * Foundation, Inc., 59 Temple Place - Suite 330, Boston, MA  02111-1307, USA
 *
 */

function make_GABA_channel

   str chanpath = "GABA"
// cf Bartos et al 2001, Dunning et al 1999, Ling et al 1998
//adjust to Avramas data instead
//   float tau1 = 2e-3
//   float tau2 = 6e-3
   float tau1 = 1.33e-3
   float tau2 = 5.7e-3
//was 2 and 6e-3 before

   float gmax = 0.5e-10
   float Ek = -0.060

   create synchan {chanpath}

   setfield {chanpath} tau1 {tau1} tau2 {tau2} gmax {gmax} Ek {Ek}

end



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