Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; NMDA; Gaba;
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striatalnetwork
FScell
channels
AddSynapticChannels.g *
AddSynapticChannels.g~ *
cellMorphology.g *
errorHandler.g *
FScell.g *
FScell.g~ *
FScell.p *
FScell.p~ *
FScellSyn.g *
FScellSyn.g~ *
include_channels.g *
include_channels.g~ *
proto.g *
proto.g~ *
SynParams.g *
SynParams.g~ *
                            
//genesis
//SynParams.g

	str AMPAname = "AMPA"
	float EkAMPA = 0.0
        float AMPAtau1 = 0.67e-3
        float AMPAtau2 = 2e-3 
        float AMPAgmax = 364e-12 //Gittis et al

        str GABAname = "GABA"
        float GABAtau1 = 1.33e-3    // From Galarreta and Hestrin 1997 
        float GABAtau2 = 4e-3    //(used in Wolfs model)
        float EkGABA = -0.060
        float GABAgmax = 50e-12  //750e-12Modified Koos 2004 (Wolf uses 435e-12)


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