Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; NMDA; Gaba;
/
striatalnetwork
FScell
channels
AddSynapticChannels.g *
AddSynapticChannels.g~ *
cellMorphology.g *
errorHandler.g *
FScell.g *
FScell.g~ *
FScell.p *
FScell.p~ *
FScellSyn.g *
FScellSyn.g~ *
include_channels.g *
include_channels.g~ *
proto.g *
proto.g~ *
SynParams.g *
SynParams.g~ *
                            
//genesis

/**************************** 	      	proto.g 				**********************
Johannes Hjorth, Sriraman Damodaran     **************************************************************
	proto.g contains one primary routine:  
		make_prototypes
 	and one local routine 
		make_cylind_compartment
	these are used by the primary and are not intended for external calls
	The primary function, make_prototypes is called exactly once by FScell.g

******************************************************************************/
include FScell/errorHandler
include FScell/include_channels		// required for calls in make_protypes

//************************ Begin Local Subroutines ****************************

//********************* Begin function make_cylind_compartment *************
function make_cylind_compartment
	if (!{exists compartment})
		echo "COMPARTMENT DID NOT EXIST PRIOR TO CALL TO:"
		echo 			"make_cylind_compartment"
		create	compartment compartment
                addfield compartment position   // add a new field "postion" to store distance to soma
	end

   setfield compartment 		\ 
     	Em         {ELEAK} 	\
      	initVm     {EREST_ACT} 	\
        inject		0.0 	\
      	position    0.0
end
//************************ End function make_cylind_compartment ************

//**************************************************************************

//************************ End Local Subroutines ******************************
//*****************************************************************************

//************** Begin function make_prototypes (primary routine) *************
function make_prototypes

       	if (!{exists /library})
  	   create neutral /library
  	   disable /library
        else
        end
	pushe /library

        make_cylind_compartment
	//********************* create non-synaptic channels in library ************************
        make_K3132_channel
        make_K13_channel
        make_A_channel
        make_Na_channel
        pope
	//********************* End channels in library ************************

end
//************************ End function make_prototypes ***********************


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