Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; NMDA; Gaba;
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striatalnetwork
MScell
channels
unusedChannels
AddCaSpines.g *
addchans.g *
addchans.g~ *
addinput.g *
addoutput.g *
addoutput.g~
addoutput_old.g *
AddSynapticChannels.g *
connectCaChannels.g *
DA_files.txt *
globals.g
globals.g~
globals_old.g
globalsCaComp.g *
include_channels.g *
MScell.g~
MScell.p *
MScell_D1.g *
MScell_D1.g~
MScell_D1_old.g
MScell_D2.g *
MScell_D2.g~
MScell_D2_old.g
MScell08.p *
MScell08CM3_D1.p *
MScell08CM3_D2.p *
MScell08CM3_old.p
MScellSpine.g *
MScellSpineCtx.g *
MScellSpineTh.g *
MScellSyn.g~ *
MScellSyn_D1.g *
MScellSyn_D2.g *
parametersA.g~
parametersA_D1.g *
parametersA_D2.g *
parametersB.g *
parametersC.g *
parametersD.g *
proto.g *
proto.g~
spines.g *
SynParams.g~
SynParams_D1.g
SynParams_D2.g
SynParamsCtx.g *
SynParamsTh.g *
                            
//genesis
//SynParams.g

	str AMPAname = "AMPA"
	float EkAMPA = 0.0
        float AMPAtau1 = 1.1e-3
        float AMPAtau2 = 5.75e-3 
        float AMPAgmax = 0.342e-9  //593e-12 I changed this to make the NMDA/AMPA ratio more like 2.75/1 which is what Ding 2008 finds int corticalstriatal synapses
									//more like 2/1 for thalamus so should be 0.47e-9 for thalamo-striatal syanpnse if NMDA is 0.94e-9 Rebekah Evans 6/25/10

        str GABAname = "GABA"
        float GABAtau1 = 0.25e-3    // From Galarreta and Hestrin 1997 
        float GABAtau2 = 3.75e-3    //(used in Wolfs model)
        float EkGABA = -0.060
        float GABAgmax = 750e-12  //Modified Koos 2004 (Wolf uses 435e-12)

	int GABA2Spine = 0                                // = 0, No GABA; 
                                                  //   1, add GABA to spine head
                                                  //   2, add GABA to spine neck
	
	int addCa2Spine = 1		// 0, no ca channels in spine, 
					//1, yes ca channels in spine (non-synaptic)
	int NMDABufferMode = 0          // 1, connect both NMDA and AMPA calcium to NMDA_buffer
                                     // 0, connect only NMDA currents to NMDA_buffer

float useAMPANMDAGHKchannels= 0  // we do not use GHK project for NMDA/AMPA

setclock 0 5e-6 //was 5e-6
        // Simulation time step (Second)       
setclock 1 2e-5        //  time step for ascii output
//setclock 1 1e-4 // time step for graphic output


// parameters for NMDA subunits


// cortex
str	    subunit = "Cortex"
float   EkNMDA   = 0
float	Kmg       = 3.57
float	NMDAtau2      = (112.5e-3)/2 	//ctx avg for .25 NR2B and .75 NR2A.  (300e-3)/2 (NR2B) (50e-3)/2 (NR2A) 75+37.5 = 112.5
float	NMDAgmax      = 0.94e-9      //NR2A and B from (Moyner et al., 1994 figure 7)
int ghk_yesno=0

str NMDAname = {subunit}

//for saving info on distal or proximal dendrites or massed and spaced. formula typeof dend, # of spines.

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