Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; NMDA; Gaba;
/
striatalnetwork
MScell
channels
unusedChannels
AddCaSpines.g *
addchans.g *
addchans.g~ *
addinput.g *
addoutput.g *
addoutput.g~
addoutput_old.g *
AddSynapticChannels.g *
connectCaChannels.g *
DA_files.txt *
globals.g
globals.g~
globals_old.g
globalsCaComp.g *
include_channels.g *
MScell.g~
MScell.p *
MScell_D1.g *
MScell_D1.g~
MScell_D1_old.g
MScell_D2.g *
MScell_D2.g~
MScell_D2_old.g
MScell08.p *
MScell08CM3_D1.p *
MScell08CM3_D2.p *
MScell08CM3_old.p
MScellSpine.g *
MScellSpineCtx.g *
MScellSpineTh.g *
MScellSyn.g~ *
MScellSyn_D1.g *
MScellSyn_D2.g *
parametersA.g~
parametersA_D1.g *
parametersA_D2.g *
parametersB.g *
parametersC.g *
parametersD.g *
proto.g *
proto.g~
spines.g *
SynParams.g~
SynParams_D1.g
SynParams_D2.g
SynParamsCtx.g *
SynParamsTh.g *
                            
//addoutput.g
	// function for saving parameter in ascii file.  
	//function is made and called in this file
	
//make function 

function sav_disk_asc(diskpath,srcpath,field)
    create asc_file /output/{diskpath}
    setfield /output/{diskpath}   flush 1  leave_open 1 append 1 \
          float_format %0.6g
    useclock /output/{diskpath} 0
    setfield /output/{diskpath} filename output/{diskpath}
    addmsg {srcpath} /output/{diskpath}  SAVE {field}
    call /output/{diskpath} OUT_OPEN
    call /output/{diskpath} OUT_WRITE "time #1" //header
    echo {diskpath}
end
		
		
		
//call function
	
	/*******************save soma information****************************************************
		//sav_disk_asc somaVm{subunit}{stimtype} {cellpath}/soma Vm
	*******************************************************************************************/
	
	/*******************save secondary dendrite parameters**************************************
		//sav_disk_asc dendCa{subunit}{stimtype} {cellpath}/secdend3/{CalciumBuffer_3} Ca  
		//sav_disk_asc NMDACa{subunit}{stimtype} {cellpath}/secdend3/spine_1/head/buffer_NMDA Ca
		//sav_disk_asc spineCa{subunit}{stimtype} {cellpath}/secdend3/spine_1/head/SpineCa Ca
		//sav_disk_asc LspineCa{subunit}{stimtype} {cellpath}/secdend3/spine_1/head/SpineCaL Ca
		//sav_disk_asc Ikblock{subunit}{stimtype} {cellpath}/secdend3/spine_1/head/{subunit}/block Ik
		//sav_disk_asc spineVm{subunit}{stimtype} {cellpath}/secdend3/spine_1/head Vm
	*******************************************************************************************/
 
	/******************save tertiary dendrite information****************************************
		sav_disk_asc dendCa{subunit}{stimtype}3 {cellpath}/tertdend3/{CalciumBuffer_3} Ca
	//	sav_disk_asc spineCa{subunit}{stimtype}3 {cellpath}/tertdend3/tert_dend5/spine_1/head/buffer_NMDA
	//	sav_disk_asc Ikblock{subunit}{stimtype}3 {cellpath}/tertdend3/tert_dend5/spine_1/head/{subunit}/block Ik Ca
	//	sav_disk_asc spineVm{subunit}{stimtype}3 {cellpath}/tertdend3/tert_dend5/spine_1/head Vm
	//	sav_disk_asc IkAMPA{stitype}3 {cellpath}/tertdend3/tert_dend5/spine_1/head/AMPA Ik
	//	sav_disk_asc IkAMPA{stitype}2 {cellpath}/tertdend3/tert_dend5/spine_1/head/AMPA Ik
	*********************************************************************************************/
 
 // this function allows you to put several columns in the same file and name them using the call function series below it.  

function add_output_both
     int ctr	
     str net_n="/SPnetwork/SPcell"
     for(ctr = 0; ctr < 100; ctr = {ctr + 1})
        create asc_file /output/CaSomaOutCell{ctr}
        create asc_file /output/CaPrim2OutCell{ctr}
        create asc_file /output/CaSec6OutCell{ctr}
        create asc_file /output/CaTert12OutCell{ctr}
        create asc_file /output/VmSec6OutCell{ctr}
        create asc_file /output/VmTert12OutCell{ctr}
        create asc_file /output/VmSomaOutCell{ctr}
        setfield /output/CaSomaOutCell{ctr}   flush 1  leave_open 1 append 1 float_format %0.6g
        setfield /output/CaPrim2OutCell{ctr}   flush 1  leave_open 1 append 1 float_format %0.6g
        setfield /output/CaSec6OutCell{ctr}   flush 1  leave_open 1 append 1 float_format %0.6g
        setfield /output/CaTert12OutCell{ctr}   flush 1  leave_open 1 append 1 float_format %0.6g
        setfield /output/VmSec6OutCell{ctr}   flush 1  leave_open 1 append 1 float_format %0.6g
        setfield /output/VmTert12OutCell{ctr}   flush 1  leave_open 1 append 1 float_format %0.6g
        setfield /output/VmSomaOutCell{ctr}   flush 1  leave_open 1 append 1 float_format %0.6g
        useclock /output/CaSomaOutCell{ctr} {CaOutDt}
        useclock /output/CaPrim2OutCell{ctr} {CaOutDt}
        useclock /output/CaSec6OutCell{ctr} {CaOutDt}
        useclock /output/CaTert12OutCell{ctr} {CaOutDt}
        useclock /output/VmSec6OutCell{ctr} {VmOutDt}
        useclock /output/VmTert12OutCell{ctr} {VmOutDt}
        useclock /output/VmSomaCell{ctr} {VmOutDt}

        addmsg {net_n}[{ctr}]/soma/{CA_BUFF_3} /output/CaSec6OutCell{ctr}  SAVE Ca  //not hooked up?
        addmsg {net_n}[{ctr}]/primdend2/{CA_BUFF_3} /output/CaTert12OutCell{ctr}  SAVE Ca  //not hooked up?
        addmsg {net_n}[{ctr}]/secdend6/{CA_BUFF_3} /output/CaSec6OutCell{ctr}  SAVE Ca  //not hooked up?
        addmsg {net_n}[{ctr}]/tertdend12/{CA_BUFF_3} /output/CaTert12OutCell{ctr}  SAVE Ca  //not hooked up?
        addmsg {net_n}[{ctr}]/secdend6 /output/VmSec6OutCell{ctr}  SAVE Vm  //not hooked up?
        addmsg {net_n}[{ctr}]/tertdend12 /output/VmTert12OutCell{ctr}  SAVE Vm  //not hooked up?        
        addmsg {net_n}[{ctr}]/soma /output/VmSomaOutCell{ctr}  SAVE Vm
 
      end
  
end
 
function check_input
	int ctr, ctr2, count=0
     	float gaba	
     	str network="/SPnetwork/SPcell", gc
	for (ctr = 0;ctr< {getglobal numCells_SP}; ctr = {ctr+1})   
		create diffamp /SPnetwork/SPcell[{ctr}]/add
		setfield /SPnetwork/SPcell[{ctr}]/add gain 1 saturation 30000 
        	foreach gc ({el /SPnetwork/SPcell[{ctr}]/##[TYPE=compartment]/GABA})
			addmsg {gc} /SPnetwork/SPcell[{ctr}]/add PLUS Gk  		
		end
	 	create asc_file /output/checkInput{ctr}
		setfield /output/checkInput{ctr}   flush 1  leave_open 1 append 1 float_format %0.6g	
		useclock /output/checkInput{ctr} 1e-3
		addmsg /SPnetwork/SPcell[{ctr}]/add /output/checkInput{ctr} SAVE output  
   	end
end

function add_output_sec 

    create xform /Cadata [265,50,400,460]
    create xlabel /Cadata/label -hgeom 5% -label {graphlabel}
    create xgraph /Cadata/Calevel -hgeom 80% -title "Ca2+ level sec3 Control" -bg white
    setfield ^ XUnits sec YUnits M
    setfield ^ xmax {tmax} ymin {1e-05} ymax {50e-05}
    //makegraphscale /Cadata/Calevel
    addmsg /SPnetwork/SPcell[0]/secdend6/{CA_BUFF_3} /Cadata/Calevel PLOTSCALE \
	Ca *"1 " *black 1 0
/*
    addmsg /SPnetwork/SPcell[1]/secdend3/{CA_BUFF_3} /Cadata/Calevel PLOTSCALE \
	Ca *"2 " *red 1 0
    addmsg /SPnetwork/SPcell[2]/secdend3/{CA_BUFF_3} /Cadata/Calevel PLOTSCALE \
	Ca *"3 " *blue 1 0
    addmsg /SPnetwork/SPcell[3]/secdend3/{CA_BUFF_3} /Cadata/Calevel PLOTSCALE \
	Ca *"4 " *green 1 0
*/  
  xshow /Cadata

end
   
function add_output_tert 
    
    create xform /Cadata2 [265,50,400,460]
    create xlabel /Cadata2/label -hgeom 5% -label {graphlabel}
    create xgraph /Cadata2/Calevel -hgeom 80% -title "Ca2+ level tert1 Control" -bg white
    setfield ^ XUnits sec YUnits M
    setfield ^ xmax {tmax} ymin {1e-05} ymax {50e-05}
    //makegraphscale /Cadata2/Calevel
    addmsg /SPnetwork/SPcell[0]/tertdend12/{CA_BUFF_3} /Cadata2/Calevel PLOTSCALE \
	Ca *"1 " *black 1 0
/*
    addmsg /SPnetwork/SPcell[1]/tertdend1/{CA_BUFF_3} /Cadata2/Calevel PLOTSCALE \
	Ca *"2 " *red 1 0
    addmsg /SPnetwork/SPcell[2]/tertdend1/{CA_BUFF_3} /Cadata2/Calevel PLOTSCALE \
	Ca *"3 " *blue 1 0
    addmsg /SPnetwork/SPcell[3]/tertdend1/{CA_BUFF_3} /Cadata2/Calevel PLOTSCALE \
	Ca *"4 " *green 1 0
*/    
  xshow /Cadata2

end
   
/*

function add_output_tert
	create asc_file /output/plot_out
	setfield /output/plot_out   flush 1  leave_open 1 append 1 \
          float_format %0.6g
    useclock /output/plot_out 1
    addmsg {cellpath}/tertdend3/tert_dend3/{CA_BUFF_3} /output/plot_out  SAVE Ca  //not hooked up?
    addmsg {cellpath}/tertdend3/tert_dend3/spine_1/head/buffer_NMDA /output/plot_out  SAVE Ca
    //addmsg {cellpath}/tertdend3/tert_dend3/tert_dend5/spine_1/head/{subunit}/block /output/plot_out  SAVE Ik
    addmsg {cellpath}/tertdend3/tert_dend3/spine_1/head/spineCaL /output/plot_out  SAVE Ca
	addmsg {cellpath}/tertdend3/tert_dend3/spine_1/head/spineCa /output/plot_out  SAVE Ca
    //addmsg {cellpath}/tertdend3/tert_dend3/spine_1/head	/output/plot_out SAVE Vm
	addmsg {cellpath}/soma /output/plot_out  SAVE Vm
	call /output/plot_out OUT_OPEN
	call /output/plot_out OUT_WRITE "time  CaDend CaNMDA   SpineLtype	SpineCa	SomaVm" //header
end

*/

/*this part goes in a sim file and calls the add_ouput file above.    
	str diskpath 
	add_output_sec
	// open file for 1AP, then run sim
	stimtype="1APnegsec"
	diskpath=(subunit)@(stimtype)@".txt"
	echo {diskpath}
	setfield /output/plot_out filename output/{diskpath}
		call /output/plot_out OUT_OPEN
		call /output/plot_out OUT_WRITE "time	-20" 
	reset
	include 1APnegsec.g
*/
   
   
   

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