Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; NMDA; Gaba;
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striatalnetwork
MScell
channels
ampa_channel.g *
BKKchannel.g *
CaL12inact_channel.g *
CaL13_channel.g *
CaNinact_channel.g *
CaR_channel.g *
CaT_channel.g *
gaba_channel.g *
K_DR_channel.g *
kAf_chanRE.g *
kAs_chanRE.g *
kIR_chanKD.g *
naF_chanOg.g *
naF_chanOg.g~
nmda_channel.g *
SKchannelCaDep.g *
synaptic_channel.g *
tabchanforms.g *
                            
//genesis

/***************************		MS Model, Version 5.0	*********************
**************************** 	    	BKKchannel.g 			*********************
		Tom Sheehan tsheeha2@gmu.edu	thsheeha@vt.edu	703-538-8361
******************************************************************************
******************************************************************************/

//==========================================================================
// /* non-inactivating BK-type Ca-dependent K current
// ** Moczydlowski and Latorre 1983, J. Gen. Physiol. 82:511-542.
// ** Implemented by Erik De Schutter BBF-UIA,
// ** with original parameters scaled for units: V, sec, mM. 
// ** Assumes tab2Dchannel "KC" has a sibling Ca_concen "Ca_conc". 
// ** Temprature is modified to be 35C                                      */

// //=======================================================================

function make_BKK_channel
    float EK=-0.9  // V
  //  int xdivs = 299
    int xdivs = 299
    int ydivs = {xdivs}
    float xmin, xmax, ymin, ymax
    xmin = -0.1; xmax = 0.05; ymin = 0.0; ymax = 0.005 // x = Vm, y = [Ca],mM
    int i, j
    float x, dx, y, dy, a, b
    float Temp = 35
    float ZFbyRT = 23210/(273.15 + Temp)
    if (!({exists BKK_channel}))
        create tab2Dchannel BKK_channel
        setfield BKK_channel Ek {EK} Gbar 0.0  \
            Xindex {VOLT_C1_INDEX} Xpower 1 Ypower 0 Zpower 0
        call BKK_channel TABCREATE X {xdivs} {xmin} {xmax} \
            {ydivs} {ymin} {ymax}
    end
    dx = (xmax - xmin)/xdivs
    dy = (ymax - ymin)/ydivs
    x = xmin
    for (i = 0; i <= xdivs; i = i + 1)
        y = ymin
        for (j = 0; j <= ydivs; j = j + 1)
            a = 480*y/(y + 0.180*{exp {-0.84*ZFbyRT*x}})
            b = 280/(1 + y/(0.011*{exp {-1.00*ZFbyRT*x}}))
            setfield BKK_channel X_A->table[{i}][{j}] {a}
            setfield BKK_channel X_B->table[{i}][{j}] {a + b}
            y = y + dy
        end
        x = x + dx
    end
    setfield BKK_channel X_A->calc_mode {LIN_INTERP}
    setfield BKK_channel X_B->calc_mode {LIN_INTERP}

end




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