Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

 Download zip file 
Help downloading and running models
Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; NMDA; Gaba;
/
striatalnetwork
MScell
unusedChannels
CaL12_channel.g *
CaL12NOINACT_channel.g *
CaN_channel.g *
CaNNOINACT_channel.g *
CaQ_channel.g *
naP_channel.g *
                            
//genesis

/***************************		MS Model, Version 5.2	*********************
**************************** 	    	CaL12channel.g 		*********************
		Tom Sheehan tsheeha2@gmu.edu	thsheeha@vt.edu	703-538-8361
******************************************************************************
******************************************************************************/

function create_CaL12
	str chanName = "CaL12_channel"
	str compPath = "/library"
	int c

	float xmin = -0.1
	float xmax = 0.05
	int 	xdivs = 3000
	float mPower = 1.0
	float hPower = 1.0
	
	float increment = 0.00005	
	float x = -0.1
  	float surf = 0
 	float gMax = 1.1390000e-008  

	float hTauCaL12 	= 1.477e-002
	float mTauCaL12 	= 0.0
	float mvHalfCaL12 = -8.9e-3
	float mkCaL12     = -6.7e-3
	float hvHalfCaL12 = -13.4e-3
	float hkCaL12     = 11.9e-3
	float hInfCaL12	= 0.0
	float mInfCaL12	= 0.0

	float theta	= 0.0
	float beta	= 0.0
	float beta_exp	= 0.0
	float mA = 0.0
	float mB = 0.0
	float qFactCaL12 	=2
	
	pushe {compPath}

	create tabchannel {chanName}
  	setfield {chanName} Xpower {mPower} Ypower {hPower}
	call {chanName} TABCREATE X {xdivs} {xmin} {xmax}
        call {chanName} TABCREATE Y {xdivs} {xmin} {xmax}	
	
	
	for(c = 0; c < {xdivs} + 1; c = c + 1)
		/************************ Begin CaL12_mTau *********************/
		//mA = 0.0398e6*(vMemb + 8.124e-3)./(exp((vMemb + 8.124e-3)/9.005e-3) - 1);
		//mB = 0.99e3*exp(vMemb/31.4e-3);
		//mTauCaL12 = 1./(mA + mB) / qFactCaL12;

		theta = 0.0398e6*{ {x} + 8.124e-3}
		beta = {{x} + 8.124e-3}/9.005e-3
		beta_exp = {exp {beta}}
		beta_exp = beta_exp - 1.0
		mA = {{theta}/{beta_exp}}
		
		beta = {{x}/31.4e-3}
		beta_exp = {exp {beta}} 
		mB = 0.99e3*{beta_exp}

		mTauCaL12 = {1/{mA + mB}}/{qFactCaL12}		
		setfield {chanName} X_A->table[{c}] {mTauCaL12}
		/************************ End CaL12_mTau ***********************/		

		/************************ Begin CaL12_mInf *********************/
		// mInfCaL12   = 1./(1 + exp((vMemb - mvHalfCaL12)/mkCaL12));
		beta = {{x} - {mvHalfCaL12}}/{mkCaL12}
		beta_exp = {exp {beta}} + 1.0
		mInfCaL12 = 1.0/{beta_exp}
		setfield {chanName} X_B->table[{c}] {mInfCaL12}
		/************************ End CaL12_mInf ***********************/	
   	x = x + increment
	end
	tweaktau {chanName} X

	x = -0.1	
	for(c = 0; c < {xdivs} + 1; c = c + 1)
		/************************ Begin CaL12_hTau *********************/
		// hTauCaL12 = 14.77e-3*ones(vDiv+1,1); % Already q-corrected
		setfield {chanName} Y_A->table[{c}] {hTauCaL12}
		/************************ End CaL12_hTau ***********************/

		/************************ Begin CaL12_hInf *********************/
		// hInfCaL12   = 1./(1 + exp((vMemb - hvHalfCaL12)/hkCaL12));
		beta = {{x} - {hvHalfCaL12}}/{hkCaL12}
		beta_exp = {exp {beta}} + 1.0
		hInfCaL12 = 1.0/{beta_exp}
		setfield {chanName} Y_B->table[{c}] {hInfCaL12}
		/************************ End CaL12_hInf ***********************/	
   	x = x + increment
	end	
	tweaktau {chanName} Y

  	create ghk {chanName}GHK

  	setfield {chanName}GHK Cout 2 // Carter & Sabatini 2004 uses 2mM, 
											// Wolf 5mM
  	setfield {chanName}GHK valency 2.0
  	setfield {chanName}GHK T {TEMPERATURE}
	
  	setfield {chanName} Gbar {gMax*surf}
  	addmsg {chanName} {chanName}GHK PERMEABILITY Gk	
  	pope 
end

Loading data, please wait...