Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; NMDA; Gaba;
//genesis
//net_conn.g - Description of the FS and SP connections to the SP network

//This file sets up the SP-SP connections based on the factor sent to the netconn function



  for(ctrpre = 0; ctrpre < {getglobal numCells_{net}}; ctrpre = {ctrpre + 1})  //loops through presynaptic cells
        xpre={getfield {network}[{ctrpre}]/soma/ x}  //get x location
	ypre={getfield {network}[{ctrpre}]/soma/ y}  //get y location

	for(ctrpost = 0; ctrpost < {getglobal numCells_{net2}}; ctrpost= {ctrpost +1})  //loops through postsynaptic cells

		if ({ctrpre}!={ctrpost}) //only if pre and post synaptic cells are different start connecting                                                                                                 
                   xpost={getfield {network2}[{ctrpost}]/soma/ x} //get x location
		   ypost={getfield {network2}[{ctrpost}]/soma/ y} //get y location

                   dist2parent={{pow {xpost-xpre} 2 } + {pow {ypost-ypre} 2}}   // calculating distance between the cells               
             

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