Bursting and oscillations in RD1 Retina driven by AII Amacrine Neuron (Choi et al. 2014)

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Accession:156781
"In many forms of retinal degeneration, photoreceptors die but inner retinal circuits remain intact. In the rd1 mouse, an established model for blinding retinal diseases, spontaneous activity in the coupled network of AII amacrine and ON cone bipolar cells leads to rhythmic bursting of ganglion cells. Since such activity could impair retinal and/or cortical responses to restored photoreceptor function, understanding its nature is important for developing treatments of retinal pathologies. Here we analyzed a compartmental model of the wild-type mouse AII amacrine cell to predict that the cell's intrinsic membrane properties, specifically, interacting fast Na and slow, M-type K conductances, would allow its membrane potential to oscillate when light-evoked excitatory synaptic inputs were withdrawn following photoreceptor degeneration. ..."
Reference:
1 . Choi H, Zhang L, Cembrowski M, Sabottke C, Markowitz A, Butts D, Kath W, Singer J, Riecke H (2014) Intrinsic Bursting of AII Amacrine Cells Underlies Oscillations in the rd1 Mouse Retina. J Neurophysiol [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Retina;
Cell Type(s):
Channel(s): I Na,t; I A; I M;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Bursting; Oscillations; Action Potentials; Bifurcation;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I A; I M;
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ChoiEtAl2014
readme.txt
A2ONCB.m
A2ONCB_FHN.m
A2ONCB_Fig5a.m
                            
This the readme for the model files associated with the paper:

Choi H, Zhang L, Cembrowski M, Sabottke C, Markowitz A, Butts D, Kath
W, Singer J, Riecke H (2014) Intrinsic Bursting of AII Amacrine Cells
Underlies Oscillations in the rd1 Mouse Retina. J Neurophysiol

These files were contributed by H Riecke.

Type A2ONCB on the matlab command line to run the basic model.
Depending on the variable plotswitch it generates Fig.5B or Fig.14 of
that paper.  To generate generate Fig.5A type A2ONCB_Fig5a. To
generate Fig.13 type A2ONC_FHN.

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