Granule Cells of the Olfactory Bulb (Simoes_De_Souza et al. 2014)

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Accession:156828
Electrical responses of three classes of granule cells of the olfactory bulb to synaptic activation in different dendritic locations. The constructed models were based on morphological detailed compartmental reconstructions of three granule cell classes of the olfactory bulb with active dendrites described by Bhalla and Bower (J. Neurophysiol. 69: 1948-1965, 1993) and dendritic spine distributions described by Woolf et al. (J. Neurosci. 11: 1837-1854, 1991). The computational studies with the model neurons showed that different quantities of spines have to be activated in each dendritic region to induce an action potential, which always was originated in the active terminal dendrites, independently of the location of the stimuli and the morphology of the dendritic tree.
References:
1 . Bhalla US, Bower JM (1993) Exploring parameter space in detailed single neuron models: simulations of the mitral and granule cells of the olfactory bulb. J Neurophysiol 69:1948-65 [PubMed]
2 . Woolf TB, Shepherd GM, Greer CA (1991) Local information processing in dendritic trees: subsets of spines in granule cells of the mammalian olfactory bulb. J Neurosci 11:1837-54 [PubMed]
3 . Simões-de-Souza FM, Antunes G, Roque AC (2014) Electrical responses of three classes of granule cells of the olfactory bulb to synaptic inputs in different dendritic locations. Front Comput Neurosci 8:128 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron granule TC GABA cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Synaptic Integration; Olfaction;
Implementer(s): Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br];
Search NeuronDB for information about:  Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron granule TC GABA cell; AMPA; NMDA;
// Type I granule cell model 
// Modified from Upinder S. Bhalla May 1991 Caltech.
// fields are ..
// name
// parent
// x,y,z  // coords of endpoint. 
// dia // needed for memb props. All lengths are in microns.
// ch name density 
// ch name density 
// .....
// Control lines start with '*'. Valid control options are 
// *relative 			- relative coords.
// *absolute			- absolute coords.
// *asymmetric			- use asymmetric compartments
// *symmetric			- use symmetric compartments

// #	name	parent		x	y	z	d	ch	dens	ch	dens	.	.	.

*asymmetric
*relative
*cartesian

*set_global	RM	12.0
*set_global	RA	0.5
*set_global	CM	0.01
*set_global	EREST_ACT	-0.065

*memb_factor	2.0


*start_cell /library/notfakespine1
notfakespine1	none		10	0	0	2
neck     	.      		1.9	0	0	0.23 
head	        .      		0.8	0	0	0.8   AMPA_NMDA -1000e-12 Ca_conc -26e10
*makeproto /library/notfakespine1

*start_cell /library/notfakespine2
notfakespine2	none		10	0	0	2
neck		.		-1.9	0	0	0.23 
head		.		-0.8	0	0	0.8   AMPA_NMDA -1000e-12 Ca_conc -26e10
*makeproto /library/notfakespine2


//*add_spines DENDR_DIAM SPINE_DENS SPINE_SUR   
//Adds membrane surface for collapsed spines to all compartments with
// dia <= DENDR_DIAM; units: DENDR_DIAM (um), SPINE_DENS (1/um), SPINE_SUR (um^2).

*add_spines 5 0.0446 3.37

*start_cell

*compt /library/notfakespine1
soma		none		0	0	8	6	Na2_rat_smsnn	1611	K_mit_usb	1313	KM_bsg_upi	1334	KA_bsg_yka	12.7	Rm	200e6

*polar

*compt /library/notfakespine2
trunk[0]	soma		40	20	10	2	Na2_rat_smsnn	1.7	K_mit_usb	71
*compt /library/notfakespine1
trunk[1]	.		40	80	10	1.5	Na2_rat_smsnn	1.7	K_mit_usb	71
*compt /library/notfakespine2
trunk[2]	.		20	110	20	1.4	Na2_rat_smsnn	1.7	K_mit_usb	71
*compt /library/notfakespine1
trunk[3]	.		20	140	10	1.3	Na2_rat_smsnn	1.7	K_mit_usb	71
*compt /library/notfakespine2
trunk[4]	.		20	160	10	1.3	Na2_rat_smsnn	1.7	K_mit_usb	71
*compt /library/notfakespine1
trunk[5]	.		20	160	20	1.3	Na2_rat_smsnn	1.7	K_mit_usb	71
*compt /library/notfakespine2
trunk[6]	.		20	180	10	1.3	Na2_rat_smsnn	1.7	K_mit_usb	71

*compt /library/notfakespine1
periph1[0]	trunk[6]	10	0	10	1.25	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph1[1]	.		10	0	20	1.25	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph1[2]	.		10	0	30	1.25	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph1[3]	.		10	0	10	1.25	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph1[4]	.		10	0	20	1.25	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph11[0]	.		10	5	20	1.2	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph11[1]	.		10	20	30	1.2	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph11[2]	.		10	40	30	1.18	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph11[3]	.		10	30	20	1.17	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph11[4]	.		10	50	10	1.16	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph11[5]	.		10	40	30	1.15	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph11[6]	.		10	30	30	1.14	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph11[7]	.		10	20	20	1.13	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph11[8]	.		10	10	10	1.12	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph11[9]	.		10	10	10	1.11	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph11[10]	.		10	20	20	1.10	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph11[11]	.		10	30	25	1.09	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph11[12]	.		10	50	20	1.08	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph11[13]	.		10	50	15	1.07	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph11[14]	.		10	30	20	1.06	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph11[15]	.		10	40	10	1.05	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph11[16]	.		10	20	30	1.04	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph11[17]	.		10	20	20	1.03	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph11[18]	.		10	10	30	1.02	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph11[19]	.		10	40	10	1.01	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph11[20]	.		10	30	20	1.00	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph12[0]	periph1[4]	10	-80	20	1.2	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph12[1]	.		10	-70	30	1.2	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph12[2]	.		10	-90	10	1.18	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph12[3]	.		10	-80	30	1.16	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph12[4]	.		10	-90	50	1.15	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph12[5]	.		10	-100	30	1.14	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph12[6]	.		10	-90	30	1.13	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph12[7]	.		10	-100	50	1.12	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph12[8]	.		10	-90	30	1.11	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph12[9]	.		10	-80	40	1.10	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph12[10]	.		10	-80	20	1.09	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph12[11]	.		10	-90	30	1.08	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph12[12]	.		10	-70	30	1.07	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph12[13]	.		10	-80	40	1.06	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph12[14]	.		10	-90	10	1.05	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph12[15]	.		10	-100	30	1.04	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph12[16]	.		10	-90	10	1.03	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph12[17]	.		10	-80	30	1.02	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph2[0]	trunk[6]	10	170	20	1.2	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph2[1]	.		10	180	30	1.2	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph2[2]	.		10	160	40	1.19	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph2[3]	.		10	150	20	1.18	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph2[4]	.		10	170	10	1.17	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph2[5]	.		10	190	10	1.16	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph2[6]	.		10	180	20	1.15	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph2[7]	.		10	180	30	1.14	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph2[8]	.		10	170	30	1.13	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph2[9]	.		10	160	10	1.12	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph2[10]	.		10	180	20	1.11	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph2[11]	.		10	160	10	1.1	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph2[12]	.		10	170	20	1.1	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph21[0]	.		10	170	20	1.03	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph21[1]	.		10	160	20	1.02	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph21[2]	.		10	150	30	1.01	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph21[3]	.		10	150	10	1.0	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph21[4]	.		10	140	30	1.0	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph21[5]	.		10	150	20	1.0	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph22[0]	periph2[12]	10	185	20	1.05	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph22[1]	.		10	190	20	1.03	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph22[2]	.		10	200	30	1.02	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph22[3]	.		10	210	30	1.01	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph22[4]	.		10	200	20	1.0	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph22[5]	.		10	220	30	1.0	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph22[6]	.		10	220	20	1.0	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
periph22[7]	.		10	210	10	1.0	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine2
periph22[8]	.		10	200	30	1.0	Na2_rat_smsnn	0	K_mit_usb	0
*compt /library/notfakespine1
deep0[0]	soma		10	55	150	1.0
*compt /library/notfakespine2
deep0[1]	.		10	45	160	0.8
*compt /library/notfakespine1
deep0[2]	.		10	65	150	0.8
*compt /library/notfakespine2
deep0[3]	.		10	35	140	0.7
*compt /library/notfakespine1
deep0[4]	.		10	45	130	0.6
*compt /library/notfakespine2
deep0[5]	.		10	55	150	0.5
*compt /library/notfakespine1
deep0[6]	.		10	45	160	0.5
*compt /library/notfakespine2

deep1[0]	soma		10	125	140	1.0
*compt /library/notfakespine1
deep1[1]	.		10	115	150	0.8
*compt /library/notfakespine2
deep1[2]	.		10	125	140	0.8
*compt /library/notfakespine1
deep1[3]	.		10	135	160	0.8
*compt /library/notfakespine2
deep1[4]	.		10	125	170	0.7
*compt /library/notfakespine1
deep1[5]	.		10	135	150	0.7
*compt /library/notfakespine2
deep1[6]	.		10	145	140	0.6
*compt /library/notfakespine1
deep1[7]	.		10	155	150	0.6
*compt /library/notfakespine2
deep1[8]	.		10	135	150	0.5

*compt /library/notfakespine1
deep2[0]	soma		10	-25	150	1.0
*compt /library/notfakespine2
deep2[1]	.		10	-35	160	0.8
*compt /library/notfakespine1
deep2[2]	.		10	-45	150	0.8
*compt /library/notfakespine2
deep2[3]	.		10	-35	140	0.7
*compt /library/notfakespine1
deep2[4]	.		10	-65	150	0.6
*compt /library/notfakespine2
deep2[5]	.		10	-55	130	0.6
*compt /library/notfakespine1
deep2[6]	.		10	-35	150	0.5
*compt /library/notfakespine2
deep2[7]	.		10	-45	140	0.5
*compt /library/notfakespine1
deep3[0]	soma		10	-145	130	1.0
*compt /library/notfakespine2
deep3[1]	.		10	-155	140	0.8
*compt /library/notfakespine1
deep3[2]	.		10	-145	130	0.8
*compt /library/notfakespine2
deep3[3]	.		10	-125	150	0.7
*compt /library/notfakespine1
deep3[4]	.		10	-135	160	0.6
*compt /library/notfakespine2
deep3[5]	.		10	-145	170	0.5
*compt /library/notfakespine1
deep3[6]	.		10	-155	150	0.5
*compt /library/notfakespine2
deep3[7]	.		10	-135	160	0.5











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