Granule Cells of the Olfactory Bulb (Simoes_De_Souza et al. 2014)

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Accession:156828
Electrical responses of three classes of granule cells of the olfactory bulb to synaptic activation in different dendritic locations. The constructed models were based on morphological detailed compartmental reconstructions of three granule cell classes of the olfactory bulb with active dendrites described by Bhalla and Bower (J. Neurophysiol. 69: 1948-1965, 1993) and dendritic spine distributions described by Woolf et al. (J. Neurosci. 11: 1837-1854, 1991). The computational studies with the model neurons showed that different quantities of spines have to be activated in each dendritic region to induce an action potential, which always was originated in the active terminal dendrites, independently of the location of the stimuli and the morphology of the dendritic tree.
References:
1 . Bhalla US, Bower JM (1993) Exploring parameter space in detailed single neuron models: simulations of the mitral and granule cells of the olfactory bulb. J Neurophysiol 69:1948-65 [PubMed]
2 . Woolf TB, Shepherd GM, Greer CA (1991) Local information processing in dendritic trees: subsets of spines in granule cells of the mammalian olfactory bulb. J Neurosci 11:1837-54 [PubMed]
3 . Simões-de-Souza FM, Antunes G, Roque AC (2014) Electrical responses of three classes of granule cells of the olfactory bulb to synaptic inputs in different dendritic locations. Front Comput Neurosci 8:128 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron granule TC GABA cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Synaptic Integration; Olfaction;
Implementer(s): Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br];
Search NeuronDB for information about:  Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron granule TC GABA cell; AMPA; NMDA;
// genesis

/**********************************************************************
**
**	DO NOT EDIT THIS FILE IN THE neurokit DIRECTORY!
**
**	Make a copy of this file in every directory that contains .p
**	files and edit the copies, in order to customize neurokit for
**	different simulations. When you run neurokit from other
**	directories, the simulator will look for the local version of
**	userprefs.g, and if it cannot find it there will look for the
**	default in the neurokit directory. This version of userprefs is
**	set up to run the Coarse Asymmetric Mitral cell demo.
**	
**	There are three aspects to customisation :
**	
**    	1	Include the appropriate script files from the /neuron/prototype
**  		directory and from wherever you have defined new prototype
**		elements.
**
**    	2	Invoke the functions that make the prototypes you want for
**		your simulation.
**
**	3	Put your preferences for the user_variables defined in
** 		defaults.g in the copies of this file.
**
**********************************************************************/

echo Using default user preferences!

/**********************************************************************
**
**	1	Including script files for prototype functions
**
**********************************************************************/

/* file for standard compartments */
include compartments 

/* file for Hodgkin-Huxley Squid Na and K channels */
include hhchan 

/* file for Upi's mitral cell channels */
include mitchan 
include newbulbchan

/* file for Upi's mitral cell synaptic channels */
include mitsynC2 // for now use channelC2 version
// later convert Neurokit to use synchan version
// include mitsyn 
include fabioproto

/************************************************************************
**  2	Invoking functions to make prototypes in the /library element
************************************************************************/

/*   To ensure that all subsequent elements are made in the library    */

//create neutral /library

disable /library

/*   To ensure that all subsequent elements are made in the library    */
	pushe /library


	/* Make the standard types of compartments  */

	make_cylind_compartment		/* makes "compartment" */
	make_sphere_compartment		/* makes "compartment_sphere" */
	make_cylind_symcompartment	/* makes "symcompartment" */
	make_sphere_symcompartment	/* makes "symcompartment_sphere" */

	/* These are some standard channels used in .p files */
	make_Na_squid_hh		/* makes "Na_squid_hh" */
	make_K_squid_hh			/* makes "K_squid_hh" */
	make_Na_mit_hh			/* makes "Na_mit_hh" */
	make_K_mit_hh			/* makes "K_mit_hh" */

make_LCa3_mit_usb
make_Na_rat_smsnn	// Na current
make_Na2_rat_smsnn
make_KA_bsg_yka
make_KM_bsg_upi
make_K_mit_usb  // K-current     
make_K2_mit_usb
make_K_slow_usb
make_Na_mit_usb
make_Na2_mit_usb
make_glu_mit_usb
make_GABA_1_mit_usb
make_GABA_2_mit_usb
make_glu_gran_usb
make_glu_pg_usb
make_olf_receptor
make_spike
make_Kca_mit_usb
make_Ca_mit_conc

make_GABA_A    /fabioproto
make_AMPA_NMDA // fabioproto
make_Ca_conc /fabioproto



	/* These are some synaptic channels for the mitral cell */
	make_glu_mit_upi		/* makes "glu_mit_upi" */
	make_GABA_mit_upi		/* makes "GABA_mit_upi" */

	/* returning to the root element */
	pope

enable /library

/*************************************************************** *******
**
**	3	Setting preferences for user-variables.
**
**********************************************************************/

/* See defaults.g for default values of these. Put your preferred
   values for these in your copy of userprefs in the directory from
   which you are running your simulations. */

user_syntype1 = "NMDA"
user_syntype2 = "AMPA"
user_help = "README"









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