CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)

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Accession:157157
This NEURON code implements a microcircuit of CA1 pyramidal neuron and consists of a detailed model of CA1 pyramidal cell and four types of inhibitory interneurons (basket, bistratified, axoaxonic and oriens lacunosum-moleculare cells). Synaptic plasticity during theta cycles at a synapse in a single spine on the stratum radiatum dendrite of the CA1 pyramidal cell is modeled using a phenomenological model of synaptic plasticity (Graupner and Brunel, PNAS 109(20):3991-3996, 2012). The code is adapted from the Poirazi CA1 pyramidal cell (ModelDB accession number 20212) and the Cutsuridis microcircuit model (ModelDB accession number 123815)
Reference:
1 . Saudargiene A, Cobb S, Graham BP (2015) A computational study on plasticity during theta cycles at Schaffer collateral synapses on CA1 pyramidal cells in the hippocampus. Hippocampus 25:208-18 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 basket cell; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Long-term Synaptic Plasticity; STDP;
Implementer(s): Saudargiene, Ausra [ausra.saudargiene at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell;
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SaudargieneEtAl2015
readme.html
ANsyn.mod *
bgka.mod *
bistableGB_DOWNUP.mod
burststim2.mod *
cad.mod
cadiffus.mod *
cagk.mod *
cal.mod *
calH.mod *
car.mod *
cat.mod *
ccanl.mod *
d3.mod *
gabaa.mod *
gabab.mod *
glutamate.mod *
gskch.mod *
h.mod
hha_old.mod *
hha2.mod *
hNa.mod *
IA.mod
ichan2.mod
Ih.mod *
kadbru.mod
kadist.mod *
kapbru.mod
kaprox.mod *
Kaxon.mod *
kca.mod *
Kdend.mod *
km.mod *
Ksoma.mod *
LcaMig.mod *
my_exp2syn.mod *
Naaxon.mod *
Nadend.mod *
nap.mod
Nasoma.mod *
nca.mod *
nmda.mod *
nmdaca.mod *
regn_stim.mod *
somacar.mod *
STDPE2Syn.mod *
apical-non-trunk-list.hoc
apical-tip-list.hoc
apical-tip-list-addendum.hoc
apical-trunk-list.hoc
axoaxonic_cell17S.hoc
axon-sec-list.hoc
BasalPath.hoc
basal-paths.hoc
basal-tree-list.hoc
basket_cell17S.hoc
bistratified_cell13S.hoc
burst_cell.hoc
current-balance.hoc *
main.hoc
map-segments-to-3d.hoc *
mod_func.c
mosinit.hoc
ObliquePath.hoc *
oblique-paths.hoc
olm_cell2.hoc
pattsN100S20P5_single.dat
PC.ses
peri-trunk-list.hoc
pyramidalNeuron.hoc
randomLocation.hoc
ranstream.hoc
screenshot.png
soma-list.hoc
stim_cell.hoc *
vector-distance.hoc
                            
// This function makes a list with primary oblique dendrites
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

objref apical_tip_list
apical_tip_list=new SectionList()

// List of obliques located at distances approximatelly less than 300 microns from the soma

proc proximals() {

  apical_dendrite[3]    apical_tip_list.append()   // 1 degree                 74.4  microns from soma
  apical_dendrite[5]    apical_tip_list.append()   // 0 degree                 57.46 (vertical distance)
  apical_dendrite[24]   apical_tip_list.append()   // 0 degree                 92.05
  apical_dendrite[30]   apical_tip_list.append()   // 0 degree  (essentially) 153.44
  apical_dendrite[34]   apical_tip_list.append()   // 2 degrees (ignore 3rd)  215.06
  apical_dendrite[45]   apical_tip_list.append()   // 0 degree. (essentially) 170.32
  apical_dendrite[51]   apical_tip_list.append()   // 2 degrees               210.93
  apical_dendrite[59]   apical_tip_list.append()   //                         189.34
  apical_dendrite[61]   apical_tip_list.append()   //                         221.55
  apical_dendrite[63]   apical_tip_list.append()   //                         231.58
  apical_dendrite[68]   apical_tip_list.append()   // 2 degrees               277.48
  apical_dendrite[70]   apical_tip_list.append()   // 0 degree                300.94
  apical_dendrite[106]  apical_tip_list.append()   // 0 degree                258.05
  apical_dendrite[107]  apical_tip_list.append()   // 0 degree                159.55      
  apical_dendrite[111]  apical_tip_list.append()   // 1 degree                106.30
  apical_dendrite[112]  apical_tip_list.append()   // 0 degree                 88.52
  apical_dendrite[115]  apical_tip_list.append()   // 1 degree                117.79
  apical_dendrite[118]  apical_tip_list.append()   // 0 degree                 81.66
}

// List of obliques located beyond 300 microns from the soma

proc distals() {    
  apical_dendrite[73]   apical_tip_list.append()   // 0 degree                334.84 
  apical_dendrite[82]   apical_tip_list.append()   // 0 degree                360.28
  apical_dendrite[86]   apical_tip_list.append()   // 0 degree                419.68
  apical_dendrite[93]   apical_tip_list.append()   // 0 degree                468.60
  apical_dendrite[97]   apical_tip_list.append()   // 0 degree                445.90
  apical_dendrite[105]  apical_tip_list.append()   // 0 degree                425.58
}

proximals()
distals()

print  "apical-tip-list.hoc executed" //Obidos



/* Make a shape graph with apical oblique dendrites
objref apical_tip_list_shape
color_index = 2
apical_tip_list_shape=new Shape()
apical_tip_list_shape.color_list(apical_tip_list,color_index)
apical_tip_list_shape.action("secname()")
apical_tip_list_shape.printfile("apical-tip-list.eps")
*/

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