CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)

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Accession:157157
This NEURON code implements a microcircuit of CA1 pyramidal neuron and consists of a detailed model of CA1 pyramidal cell and four types of inhibitory interneurons (basket, bistratified, axoaxonic and oriens lacunosum-moleculare cells). Synaptic plasticity during theta cycles at a synapse in a single spine on the stratum radiatum dendrite of the CA1 pyramidal cell is modeled using a phenomenological model of synaptic plasticity (Graupner and Brunel, PNAS 109(20):3991-3996, 2012). The code is adapted from the Poirazi CA1 pyramidal cell (ModelDB accession number 20212) and the Cutsuridis microcircuit model (ModelDB accession number 123815)
Reference:
1 . Saudargiene A, Cobb S, Graham BP (2015) A computational study on plasticity during theta cycles at Schaffer collateral synapses on CA1 pyramidal cells in the hippocampus. Hippocampus 25:208-18 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell; Hippocampus CA1 basket cell; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Long-term Synaptic Plasticity; STDP;
Implementer(s): Saudargiene, Ausra [ausra.saudargiene at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell;
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SaudargieneEtAl2015
readme.html
ANsyn.mod *
bgka.mod *
bistableGB_DOWNUP.mod
burststim2.mod *
cad.mod
cadiffus.mod *
cagk.mod *
cal.mod *
calH.mod *
car.mod *
cat.mod *
ccanl.mod *
d3.mod *
gabaa.mod *
gabab.mod *
glutamate.mod *
gskch.mod *
h.mod
hha_old.mod *
hha2.mod *
hNa.mod *
IA.mod
ichan2.mod
Ih.mod *
kadbru.mod
kadist.mod *
kapbru.mod
kaprox.mod *
Kaxon.mod *
kca.mod *
Kdend.mod *
km.mod *
Ksoma.mod *
LcaMig.mod *
my_exp2syn.mod *
Naaxon.mod *
Nadend.mod *
nap.mod
Nasoma.mod *
nca.mod *
nmda.mod *
nmdaca.mod *
regn_stim.mod *
somacar.mod *
STDPE2Syn.mod *
apical-non-trunk-list.hoc
apical-tip-list.hoc
apical-tip-list-addendum.hoc
apical-trunk-list.hoc
axoaxonic_cell17S.hoc
axon-sec-list.hoc
BasalPath.hoc
basal-paths.hoc
basal-tree-list.hoc
basket_cell17S.hoc
bistratified_cell13S.hoc
burst_cell.hoc
current-balance.hoc *
main.hoc
map-segments-to-3d.hoc *
mod_func.c
mosinit.hoc
ObliquePath.hoc *
oblique-paths.hoc
olm_cell2.hoc
pattsN100S20P5_single.dat
PC.ses
peri-trunk-list.hoc
pyramidalNeuron.hoc
randomLocation.hoc
ranstream.hoc
screenshot.png
soma-list.hoc
stim_cell.hoc *
vector-distance.hoc
                            
// For each section location, define x,y,z coordinates so it can be
// displayed in 3-D

proc endpt() {
  P=(n3d()-1)*$1

  x_d3($1)=x3d(P)
  y_d3($1)=y3d(P)
  z_d3($1)=z3d(P)

}
proc fracpt() { local posn, A
  A=$1
  posn=$2
  x_d3(posn)=x3d(i-1) + (x3d(i) - x3d(i-1))*A
  y_d3(posn)=y3d(i-1) + (y3d(i) - y3d(i-1))*A
  z_d3(posn)=z3d(i-1) + (z3d(i) - z3d(i-1))*A

}
proc map_segments_to_3d() {

    forall {
    
    insert d3
    i=0
    endpt(0)

    for (x) if (x > 0 && x < 1) {

      while (arc3d(i)/L < x) {
        i += 1
      }
      D=arc3d(i) - arc3d(i-1)
      if (D <= 0) {
      printf("\t\t * %s had a D < 0\n", secname())
      }
      alpha = (x*L - arc3d(i-1))/D
      fracpt(alpha,x)

    }
    endpt(1)

  }
}


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