CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)

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Accession:157157
This NEURON code implements a microcircuit of CA1 pyramidal neuron and consists of a detailed model of CA1 pyramidal cell and four types of inhibitory interneurons (basket, bistratified, axoaxonic and oriens lacunosum-moleculare cells). Synaptic plasticity during theta cycles at a synapse in a single spine on the stratum radiatum dendrite of the CA1 pyramidal cell is modeled using a phenomenological model of synaptic plasticity (Graupner and Brunel, PNAS 109(20):3991-3996, 2012). The code is adapted from the Poirazi CA1 pyramidal cell (ModelDB accession number 20212) and the Cutsuridis microcircuit model (ModelDB accession number 123815)
Reference:
1 . Saudargiene A, Cobb S, Graham BP (2015) A computational study on plasticity during theta cycles at Schaffer collateral synapses on CA1 pyramidal cells in the hippocampus. Hippocampus 25:208-18 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 basket cell; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Long-term Synaptic Plasticity; STDP;
Implementer(s): Saudargiene, Ausra [ausra.saudargiene at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell;
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SaudargieneEtAl2015
readme.html
ANsyn.mod *
bgka.mod *
bistableGB_DOWNUP.mod
burststim2.mod *
cad.mod
cadiffus.mod *
cagk.mod *
cal.mod *
calH.mod *
car.mod *
cat.mod *
ccanl.mod *
d3.mod *
gabaa.mod *
gabab.mod *
glutamate.mod *
gskch.mod *
h.mod
hha_old.mod *
hha2.mod *
hNa.mod *
IA.mod
ichan2.mod
Ih.mod *
kadbru.mod
kadist.mod *
kapbru.mod
kaprox.mod *
Kaxon.mod *
kca.mod *
Kdend.mod *
km.mod *
Ksoma.mod *
LcaMig.mod *
my_exp2syn.mod *
Naaxon.mod *
Nadend.mod *
nap.mod
Nasoma.mod *
nca.mod *
nmda.mod *
nmdaca.mod *
regn_stim.mod *
somacar.mod *
STDPE2Syn.mod *
apical-non-trunk-list.hoc
apical-tip-list.hoc
apical-tip-list-addendum.hoc
apical-trunk-list.hoc
axoaxonic_cell17S.hoc
axon-sec-list.hoc
BasalPath.hoc
basal-paths.hoc
basal-tree-list.hoc
basket_cell17S.hoc
bistratified_cell13S.hoc
burst_cell.hoc
current-balance.hoc *
main.hoc
map-segments-to-3d.hoc *
mod_func.c
mosinit.hoc
ObliquePath.hoc *
oblique-paths.hoc
olm_cell2.hoc
pattsN100S20P5_single.dat
PC.ses
peri-trunk-list.hoc
pyramidalNeuron.hoc
randomLocation.hoc
ranstream.hoc
screenshot.png
soma-list.hoc
stim_cell.hoc *
vector-distance.hoc
                            
TITLE CaGk
: Calcium activated mAHP K channel.
: From Moczydlowski and Latorre (1983) J. Gen. Physiol. 82

UNITS {
	(molar) = (1/liter)
}

UNITS {
	(mV) =	(millivolt)
	(mA) =	(milliamp)
	(mM) =	(millimolar)
}

INDEPENDENT {t FROM 0 TO 1 WITH 100 (ms)}

NEURON {
	SUFFIX mykca
	USEION ca READ cai
	USEION k READ ek WRITE ik
	RANGE gkbar, ik
	GLOBAL oinf, tau
}

UNITS {
	FARADAY = (faraday)  (kilocoulombs)
	R = 8.313424 (joule/degC)
}

PARAMETER {
	v		(mV)
	dt		(ms)
	ek		(mV)
	celsius = 20	(degC)
	gkbar = 0.01	(mho/cm2)	: Maximum Permeability
	cai = 1e-3	(mM)
	d1 = 0.84
	d2 = 1.0
	k1 = 0.18	(mM)
	k2 = 0.011	(mM)
	bbar = 0.28	(/ms)
	abar = 0.48	(/ms)
}
COMMENT
the preceding two numbers were switched on 8/19/92 in response to a bug
report by Bartlett Mel. In the paper the kinetic scheme is
C <-> CCa (K1)
CCa <-> OCa (beta2,alpha2)
OCa <-> OCa2 (K4)
In this model abar = beta2 and bbar = alpha2 and K4 comes from d2 and k2
I was forcing things into a nomenclature where alpha is the rate from
closed to open. Unfortunately I didn't switch the numbers.
ENDCOMMENT

ASSIGNED {
	ik		(mA/cm2)
	oinf
	tau		(ms)
}

STATE {	o }		: fraction of open channels

BREAKPOINT {
	SOLVE state
	ik = gkbar*o*(v - ek) : potassium current induced by this channel
}

LOCAL fac

:if state_cagk is called from hoc, garbage or segmentation violation will
:result because range variables won't have correct pointer.  This is because
:only BREAKPOINT sets up the correct pointers to range variables.
PROCEDURE state() {	: exact when v held constant; integrates over dt step
	rate(v, cai)
	o = o + fac*(oinf - o)
	VERBATIM
	return 0;
	ENDVERBATIM
}

INITIAL {           : initialize the following parameter using rate()
	rate(v, cai)
	o = oinf
}

FUNCTION alp(v (mV), ca (mM)) (1/ms) { :callable from hoc
	alp = abar/(1 + exp1(k1,d1,v)/ca)
}

FUNCTION bet(v (mV), ca (mM)) (1/ms) { :callable from hoc
	bet = bbar/(1 + ca/exp1(k2,d2,v))
}  

FUNCTION exp1(k (mM), d, v (mV)) (mM) { :callable from hoc
	exp1 = k*exp(-2*d*FARADAY*v/R/(273.15 + celsius))
}

PROCEDURE rate(v (mV), ca (mM)) { :callable from hoc
	LOCAL a
	a = alp(v,ca)
	tau = 1/(a + bet(v, ca)) : estimation of activation tau
	oinf = a*tau             : estimation of activation steady state value
	fac = (1 - exp(-dt/tau))
}

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