Distal inhibitory control of sensory-evoked excitation (Egger, Schmitt et al. 2015)

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Accession:167499
Model of a cortical layer (L) 2 pyramidal neuron embedded in an anatomically realistic network of two barrel columns in rat vibrissal cortex. This model is used to investigate the effects of spatially and temporally specific inhibition from L1 inhibitory interneurons on the sensory-evoked subthreshold responses of the L2 pyramidal neuron, and can be used to create simulation results underlying Figures 3D, 4B, 4C and 4E from (Egger, Schmitt et al. 2015).
Reference:
1 . Egger R, Schmitt AC, Wallace DJ, Sakmann B, Oberlaender M, Kerr JN (2015) Robustness of sensory-evoked excitation is increased by inhibitory inputs to distal apical tuft dendrites. Proc Natl Acad Sci U S A 112:14072-7 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Python;
Model Concept(s): Active Dendrites; Synaptic Integration; Sensory processing; Whisking;
Implementer(s): Egger, Robert [robert.egger at nyumc.org];
Search NeuronDB for information about:  Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell; GabaA; AMPA; NMDA; Gaba; Glutamate;
TITLE anomalous (inward) rectifying membrane

COMMENT
	Phenomenological model of a anomalous rectifying membrane using 
	a quadratic approximation of the subthreshold VI-relationship.
	
	Implemented by Fritjof Helmchen, MPI for Medical Research, Heidelberg
	Dec. 2004

ENDCOMMENT

UNITS {
         (mV) = (millivolt)
         (mA) = (milliamp)
	   (S)  = (siemens)
}

INDEPENDENT {v FROM -100 TO 50 WITH 50 (mV)}

NEURON {
         SUFFIX ar
         NONSPECIFIC_CURRENT i
         :RANGE g, e, c
         RANGE g0, e, c
}

PARAMETER {
         g0 = .0001      (S/cm2)       <0,1e9>
         e = -75 	  	 (mV)
         c = 1000000 	 (cm4 ohm2/mV)
}
  
ASSIGNED { i (mA/cm2) g (S/cm2) }

BREAKPOINT {
	if (c==0) {
		g = g0
		i = g0*(v-e)
	} else {
		g = 1/sqrt(1/g0^2+4*c*(v-e)) 
		i = ( -1/g0 + 1/g)/(2*c)
	}
}

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