Spreading depression model for FHM3 with Nav1.1 mutation (Dahlem et al. 2014)

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Accession:167715
Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura. A mutation causing FHM type 3 (FHM3) has been identified in SCN1A encoding the Nav1.1 Na+ channel. This genetic defect affects the inactivation gate. The code describes an extended Hodgkin-Huxley framework with dynamic ion concentrations in a wilde-type and mutant form.
Reference:
1 . Dahlem MA, Schumacher J, Hubel N (2014) Linking a genetic defect in migraine to spreading depression in a computational model. PeerJ 2:e379 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,t; I K; I K,leak; Na/K pump; I Cl, leak; I Na, leak;
Gap Junctions:
Receptor(s):
Gene(s): Nav1.1 SCN1A;
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s):
Implementer(s):
Search NeuronDB for information about:  I Na,t; I K; I K,leak; Na/K pump; I Cl, leak; I Na, leak;
/
sd
README.txt
sd-mutation.ode
sd-wild-type.ode
                            
Two programs 

* sd-wild-type.ode
* sd-mutation.ode
 
See:

M. A. Dahlem, J. Schumacher, and N. Huebel (2014) Linking a genetic
defect in migraine to spreading depression in a computational model,
PeerJ, 2:e379, http://dx.doi.org/10.7717/peerj.379

Purpose: Model spreading depression with an extended Hodgkin-Huxley
framework that includes time-dependend ion concentrations and to
establish a connection between a migraine genotype, namely the
familial hemiplegic migraine type 3 (FHM3), and cellular phenotype of
this disease.

Code for xppaut.

Email: markus.dahlem@gmail.com
Web: https://sites.google.com/site/markusadahlem/


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