Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)

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Accession:168310
This is a model network of prefrontal cortical microcircuit based primarily on rodent data. It includes 16 pyramidal model neurons, 2 fast spiking interneuron models, 1 regular spiking interneuron model and 1 irregular spiking interneuron model. The goal of the paper was to use this model network to determine the role of specific interneuron subtypes in persistent activity
Reference:
1 . Konstantoudaki X, Papoutsi A, Chalkiadaki K, Poirazi P, Sidiropoulou K (2014) Modulatory effects of inhibition on persistent activity in a cortical microcircuit model. Front Neural Circuits 8:7 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron; Neocortex spiking irregular interneuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I_Ks; I_KD;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Synchronization; Active Dendrites;
Implementer(s): Sidiropoulou, Kyriaki [sidirop at imbb.forth.gr]; Konstantoudaki, Xanthippi [xeniakons at gmail.com];
Search NeuronDB for information about:  GabaA; GabaB; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I_Ks; I_KD; Gaba; Glutamate;
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KonstantoudakiEtAl2014
experiment
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TITLE N-type calcium channel 
: used in somatic and dendritic regions 
: After Borg 
:  Updated by Maria Markaki  03/12/03

NEURON {
	SUFFIX can
	USEION ca READ cai, eca WRITE ica 
        RANGE gcabar, ica, po
	GLOBAL hinf, minf, s_inf
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(molar) = (1/liter)
	(mM) =	(millimolar)
	FARADAY = (faraday) (coulomb)
	R = (k-mole) (joule/degC)
}

PARAMETER {           :parameters that can be entered when function is called in cell-setup 
	gcabar = 0   (mho/cm2)  : initialized conductance
  	ki     = 0.025  (mM)            :test middle point of inactivation fct
	zetam = -3.4
	zetah = 2
	vhalfm =-21 (mV)
	vhalfh =-40 (mV)
	tm0=1.5(ms)
	th0=75(ms)
	taumin  = 2    (ms)            : minimal value of the time cst
}



ASSIGNED {     : parameters needed to solve DE
	v            (mV)
	celsius      (degC)
	ica          (mA/cm2)
	po
	cai          (mM)      
	eca             (mV)
        minf
        hinf
	s_inf
}


FUNCTION h2(cai(mM)) {
	h2 = ki/(ki+cai)
}



STATE {	
	m 
	h 
	s
}  

INITIAL {
	rates(v,cai)
        m = minf
        h = hinf
	s = s_inf
}

BREAKPOINT {
	SOLVE states METHOD cnexp
	po = m*m*h
 	ica = gcabar *po*h2(cai) * (v - eca)

}


FUNCTION ghk(v(mV), ci(mM), co(mM)) (.001 coul/cm3) {
	LOCAL z, eci, eco
	z = (1e-3)*2*FARADAY*v/(R*(celsius+273.15))
	eco = co*efun(z)
	eci = ci*efun(-z)
	ghk = (.001)*2*FARADAY*(eci - eco)
}

FUNCTION efun(z) {
	if (fabs(z) < 1e-4) {
		efun = 1 - z/2
	}else{
		efun = z/(exp(z) - 1)
	}
}

DERIVATIVE states {
	rates(v,cai)
	m' = (minf -m)/tm0
	h'=  (hinf - h)/th0
	s' = (s_inf-s)/taumin
}



PROCEDURE rates(v (mV), cai(mM)) { 
        LOCAL a, b, alpha2
        
	a = alpm(v)
	minf = 1/(1+a)
        
        b = alph(v)
	hinf = 1/(1+b)
	alpha2 = (ki/cai)^2
	s_inf = alpha2 / (alpha2 + 1)
}




FUNCTION alpm(v(mV)) {
UNITSOFF
  alpm = exp(1.e-3*zetam*(v-vhalfm)*9.648e4/(8.315*(273.16+celsius))) 
UNITSON
}

FUNCTION alph(v(mV)) {
UNITSOFF
  alph = exp(1.e-3*zetah*(v-vhalfh)*9.648e4/(8.315*(273.16+celsius))) 
UNITSON
}


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