Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)

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Accession:168310
This is a model network of prefrontal cortical microcircuit based primarily on rodent data. It includes 16 pyramidal model neurons, 2 fast spiking interneuron models, 1 regular spiking interneuron model and 1 irregular spiking interneuron model. The goal of the paper was to use this model network to determine the role of specific interneuron subtypes in persistent activity
Reference:
1 . Konstantoudaki X, Papoutsi A, Chalkiadaki K, Poirazi P, Sidiropoulou K (2014) Modulatory effects of inhibition on persistent activity in a cortical microcircuit model. Front Neural Circuits 8:7 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron; Neocortex spiking irregular interneuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I_Ks; I_KD;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Synchronization; Active Dendrites;
Implementer(s): Sidiropoulou, Kyriaki [sidirop at imbb.forth.gr]; Konstantoudaki, Xanthippi [xeniakons at gmail.com];
Search NeuronDB for information about:  GabaA; GabaB; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I_Ks; I_KD; Gaba; Glutamate;
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KonstantoudakiEtAl2014
experiment
data
ampa.mod *
ampain.mod *
cadyn.mod *
cadynin.mod *
cal.mod *
calc.mod *
calcb.mod *
can.mod *
cancr.mod *
canin.mod *
car.mod *
cat.mod *
catcb.mod *
gabaa.mod *
gabaain.mod *
gabab.mod *
h.mod *
hcb.mod *
hin.mod *
ican.mod *
iccb.mod *
iccr.mod *
icin.mod *
iks.mod *
ikscb.mod *
ikscr.mod *
iksin.mod *
kadist.mod *
kadistcr.mod *
kadistin.mod *
kaprox.mod *
kaproxcb.mod *
kaproxin.mod *
kca.mod *
kcain.mod *
kct.mod *
kctin.mod *
kdr.mod *
kdrcb.mod *
kdrcr.mod *
kdrin.mod *
naf.mod *
nafcb.mod *
nafcr.mod *
nafin.mod *
nafx.mod *
nap.mod *
netstim.mod *
NMDA.mod *
NMDAIN.mod *
sinclamp.mod *
cb.hoc
cr.hoc
ExperimentControl.hoc *
final.hoc
incell.hoc
net.hoc
pfc_pc_temp.hoc
run
run_orig
                            
//Interneuron for PFC - Calbindin/LTS interneuron
//Written 25-10-2007 by Xenia Konstantoudaki


begintemplate CBcell

public soma, axon, dend

create soma, axon, dend

proc init () {

create soma, axon, dend

soma_nafcb=0.075 
soma_kdrcb=0.018 
soma_hcb=0.000002 
soma_kapcb=0.007*5
soma_catcb=0.003 

soma {
     nseg=1
     L=42 
     diam=42 

	insert pas
	cm=1.2            //microF/cm2
	g_pas =1/40000
	e_pas = v_initcb
	v_initcb= -64
	Ra=150 



     insert Nafx
     gnafbar_Nafx= soma_nafcb

     insert kdrcb 
     gkdrbar_kdrcb= soma_kdrcb

     insert hcb
     gbar_hcb= soma_hcb

     insert kapcb
     gkabar_kapcb= soma_kapcb

     insert catcb
     gcatbar_catcb=soma_catcb

     insert cadyn
}

axon {
	nseg=1
	L=113.22 
	diam=1.1
	insert pas
	cm=1.2            //microF/cm2
	g_pas =1/40000
	e_pas = v_initcb
	v_initcb= -64
	Ra=150 
	
	insert Nafx
	gnafbar_Nafx= soma_nafcb*10

	insert kdrcb
	gkdrbar_kdrcb= soma_kdrcb*0.5
}

dend {
	nseg=1
	L=22
	diam=7


	insert pas
	cm=1.2            //microF/cm2
	g_pas =1/40000
	e_pas = v_initcb
	v_initcb= -64
	Ra=150 
	
	insert Nafx
	gnafbar_Nafx=0.018

	insert kdrcb
	gkdrbar_kdrcb=0.018*0.5

  	insert kapcb
     	gkabar_kapcb=0.00875


}

	ko0_k_ion = 3.82   //mM
 	ki0_k_ion = 140    //mM
	celsius   = 23
	connect axon(0), soma(0.5)
	connect dend(0), soma(0)
}

init()

endtemplate CBcell

//Creating new interneurons

nCBcells = 1
objref CBcells[nCBcells]

for i = 0, nCBcells-1 {
CBcells[i] = new CBcell()
}

//Create list with segments
objref cbsoma_list, cbcell_list

cbsoma_list = new SectionList()
for i=0, nCBcells-1 {
CBcells[i].soma cbsoma_list.append()
}

cbcell_list = new SectionList()
for i=0, nCBcells-1 {
CBcells[i].soma cbcell_list.append()
CBcells[i].axon cbcell_list.append()
CBcells[i].dend cbcell_list.append()
}


xopen("../bash_templates/current-balancecb.hoc")
current_balancecb(-64)  

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