Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)

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Accession:168310
This is a model network of prefrontal cortical microcircuit based primarily on rodent data. It includes 16 pyramidal model neurons, 2 fast spiking interneuron models, 1 regular spiking interneuron model and 1 irregular spiking interneuron model. The goal of the paper was to use this model network to determine the role of specific interneuron subtypes in persistent activity
Reference:
1 . Konstantoudaki X, Papoutsi A, Chalkiadaki K, Poirazi P, Sidiropoulou K (2014) Modulatory effects of inhibition on persistent activity in a cortical microcircuit model. Front Neural Circuits 8:7 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron; Neocortex spiking irregular interneuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I_Ks; I_KD;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Synchronization; Active Dendrites;
Implementer(s): Sidiropoulou, Kyriaki [sidirop at imbb.forth.gr]; Konstantoudaki, Xanthippi [xeniakons at gmail.com];
Search NeuronDB for information about:  GabaA; GabaB; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I_Ks; I_KD; Gaba; Glutamate;
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KonstantoudakiEtAl2014
experiment
data
ampa.mod *
ampain.mod *
cadyn.mod *
cadynin.mod *
cal.mod *
calc.mod *
calcb.mod *
can.mod *
cancr.mod *
canin.mod *
car.mod *
cat.mod *
catcb.mod *
gabaa.mod *
gabaain.mod *
gabab.mod *
h.mod *
hcb.mod *
hin.mod *
ican.mod *
iccb.mod *
iccr.mod *
icin.mod *
iks.mod *
ikscb.mod *
ikscr.mod *
iksin.mod *
kadist.mod *
kadistcr.mod *
kadistin.mod *
kaprox.mod *
kaproxcb.mod *
kaproxin.mod *
kca.mod *
kcain.mod *
kct.mod *
kctin.mod *
kdr.mod *
kdrcb.mod *
kdrcr.mod *
kdrin.mod *
naf.mod *
nafcb.mod *
nafcr.mod *
nafin.mod *
nafx.mod *
nap.mod *
netstim.mod *
NMDA.mod *
NMDAIN.mod *
sinclamp.mod *
cb.hoc
cr.hoc
ExperimentControl.hoc *
final.hoc
incell.hoc
net.hoc
pfc_pc_temp.hoc
run
run_orig
                            
//"Irregular spiking in NMDA-driven prefrontal cortex neurons"
//Written 25-10-07 by Xenia Konstantoudaki
//Based on Toledo-Rodriguez, 2004 (SK2, Kv3.4, Caa1B)


begintemplate CRcell

public soma, axon, dend

create soma, axon, dend[2]



proc init () {

create soma, axon, dend[2]

soma_nafcr=0.015
soma_kdrcr=0.018 
soma_Kslowcr=0.000725
soma_iCcr=0.00003
soma_kadcr=0.003
soma_cancr=0.001

soma {
     nseg=1
     L=27
     diam=27

	insert pas
	cm=1.2            //microF/cm2
	g_pas =1/20000
	e_pas = v_initcr
	v_initcr= -70
	Ra=150 



     insert Nafcr
     gnafbar_Nafcr= soma_nafcr

     insert kdrcr
     gkdrbar_kdrcr= soma_kdrcr

     insert IKscr
     gKsbar_IKscr= soma_Kslowcr

     insert iCcr
     gkcbar_iCcr= soma_iCcr

     insert kadcr
     gkabar_kadcr= soma_kadcr

     insert cancr
     gcatbar_cancr=soma_cancr

     insert cadyn
}

axon {
	nseg=1
	L=113.22
	diam=1.1


	insert pas
	cm=1.2            //microF/cm2
	g_pas =1/20000
	e_pas = v_initcr
	v_initcr= -70
	Ra=150 
	
	insert Nafcr
	gnafbar_Nafcr= soma_nafcr*10

	insert kdrcr
	gkdrbar_kdrcr= soma_kdrcr*0.5
}

dend[0] {
	nseg=1
	L=22
	diam=7

	
	insert pas
	cm=1.2            //microF/cm2
	g_pas =1/20000
	e_pas = v_initcr
	v_initcr= -70
	Ra=150 

	insert Nafcr
	gnafbar_Nafcr=0.018*5

	insert kdrcr
	gkdrbar_kdrcr=0.018*0.5
}

dend[1] {
	nseg=1
	L=22
	diam=7

	
	insert pas
	cm=1.2            //microF/cm2
	g_pas =1/20000
	e_pas = v_initcr
	v_initcr= -70
	Ra=150 

	insert Nafcr
	gnafbar_Nafcr=0.018*5

	insert kdrcr
	gkdrbar_kdrcr=0.018*0.5
}


	ko0_k_ion = 3.82   //mM
 	ki0_k_ion = 140    //mM
	celsius   = 23

	connect dend[0](0), soma(0)
	connect dend[1](0), soma(1)
	connect axon(0), soma(0.5)
	
   
}

init()

endtemplate CRcell

//Creating new interneurons

nCRcells = 1
objref CRcells[nCRcells]

for i = 0, nCRcells-1 {
CRcells[i] = new CRcell()
}

//Create list with segments
objref crsoma_list, crcell_list

crsoma_list = new SectionList()
for i=0, nCRcells-1 {
CRcells[i].soma crsoma_list.append()
}

crcell_list = new SectionList()
for i=0, nCRcells-1 {
CRcells[i].soma crcell_list.append()
CRcells[i].axon crcell_list.append()
CRcells[i].dend[0] crcell_list.append()
CRcells[i].dend[1] crcell_list.append()
}


xopen("../bash_templates/current-balancecr.hoc")
current_balancecr(-70)  

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