Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)

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Accession:168310
This is a model network of prefrontal cortical microcircuit based primarily on rodent data. It includes 16 pyramidal model neurons, 2 fast spiking interneuron models, 1 regular spiking interneuron model and 1 irregular spiking interneuron model. The goal of the paper was to use this model network to determine the role of specific interneuron subtypes in persistent activity
Reference:
1 . Konstantoudaki X, Papoutsi A, Chalkiadaki K, Poirazi P, Sidiropoulou K (2014) Modulatory effects of inhibition on persistent activity in a cortical microcircuit model. Front Neural Circuits 8:7 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron; Neocortex spiking irregular interneuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I_Ks; I_KD;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Synchronization; Active Dendrites;
Implementer(s): Sidiropoulou, Kyriaki [sidirop at imbb.forth.gr]; Konstantoudaki, Xanthippi [xeniakons at gmail.com];
Search NeuronDB for information about:  GabaA; GabaB; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I_Ks; I_KD; Gaba; Glutamate;
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KonstantoudakiEtAl2014
experiment
data
ampa.mod
ampain.mod
cadyn.mod
cadynin.mod
cal.mod
calc.mod
calcb.mod
can.mod
cancr.mod
canin.mod
car.mod
cat.mod
catcb.mod
gabaa.mod *
gabaain.mod
gabab.mod
h.mod
hcb.mod
hin.mod
ican.mod
iccb.mod
iccr.mod
icin.mod
iks.mod
ikscb.mod
ikscr.mod
iksin.mod
kadist.mod
kadistcr.mod
kadistin.mod
kaprox.mod
kaproxcb.mod
kaproxin.mod
kca.mod
kcain.mod
kct.mod
kctin.mod
kdr.mod *
kdrcb.mod
kdrcr.mod
kdrin.mod
naf.mod
nafcb.mod
nafcr.mod
nafin.mod
nafx.mod
nap.mod *
netstim.mod *
NMDA.mod
NMDAIN.mod
sinclamp.mod *
cb.hoc
cr.hoc
ExperimentControl.hoc *
final.hoc
incell.hoc
net.hoc
pfc_pc_temp.hoc
run
run_orig
                            
: Slowly inactivating K+ channel

NEURON {
	SUFFIX IKscr
	USEION k READ ki, ko WRITE ik
	RANGE gKsbar, ik, gk
	
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
        (mM) = (milli/liter)
	
}
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
PARAMETER {
	v (mV)
	dt (ms)
	gKsbar= 0.00014 (mho/cm2) <0,1e9>
	
}


STATE {
	a b
}


ASSIGNED {
	ik (mA/cm2)
	ainf binf
	atau (ms)
	btau (ms)
	gk (mho/cm2)
	ek  (mV)
	ki (mM)
	ko  (mM)
}



INITIAL {
	rate(v)
	a = ainf
	b = binf
}

BREAKPOINT {
	SOLVE states METHOD cnexp
		
	gk = gKsbar * a * b
	ek = 25 * log(ko/ki)
	ik = gk*(v-ek)
	
}

DERIVATIVE states {
	rate(v)
	
	a' = (ainf-a)/atau
	b' = (binf-b)/btau
}
UNITSOFF

PROCEDURE rate(v (mV)) {LOCAL va, vb, vc, vd
	
	
	va = v + 34
	vb = v + 65
	vd = v + 63.6
	

if (fabs(va)<1e-04){ va = va+0.00001 }
	   ainf = 1/(1 + exp(-va/6.5))
	   atau = 10
	  :atau=6
	

if (fabs(vb)<1e-04){ vb = vb+0.00001 }
	   binf = 1/(1 + exp(vb/6.6))

 
if (fabs(vd)<1e-04){ vd = vd+0.00001 }
	   btau = 200 + 3200 / (1 + exp(-vd/4))
	:btau = 200 + 3200 / (1 + exp(-vd/4))
}

	
UNITSON








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