Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)

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Accession:168310
This is a model network of prefrontal cortical microcircuit based primarily on rodent data. It includes 16 pyramidal model neurons, 2 fast spiking interneuron models, 1 regular spiking interneuron model and 1 irregular spiking interneuron model. The goal of the paper was to use this model network to determine the role of specific interneuron subtypes in persistent activity
Reference:
1 . Konstantoudaki X, Papoutsi A, Chalkiadaki K, Poirazi P, Sidiropoulou K (2014) Modulatory effects of inhibition on persistent activity in a cortical microcircuit model. Front Neural Circuits 8:7 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron; Neocortex spiking irregular interneuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I_Ks; I_KD;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Synchronization; Active Dendrites;
Implementer(s): Sidiropoulou, Kyriaki [sidirop at imbb.forth.gr]; Konstantoudaki, Xanthippi [xeniakons at gmail.com];
Search NeuronDB for information about:  GabaA; GabaB; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I_Ks; I_KD; Gaba; Glutamate;
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KonstantoudakiEtAl2014
experiment
data
ampa.mod
ampain.mod
cadyn.mod
cadynin.mod
cal.mod
calc.mod
calcb.mod
can.mod
cancr.mod
canin.mod
car.mod
cat.mod
catcb.mod
gabaa.mod *
gabaain.mod
gabab.mod
h.mod
hcb.mod
hin.mod
ican.mod
iccb.mod
iccr.mod
icin.mod
iks.mod
ikscb.mod
ikscr.mod
iksin.mod
kadist.mod
kadistcr.mod
kadistin.mod
kaprox.mod
kaproxcb.mod
kaproxin.mod
kca.mod
kcain.mod
kct.mod
kctin.mod
kdr.mod *
kdrcb.mod
kdrcr.mod
kdrin.mod
naf.mod
nafcb.mod
nafcr.mod
nafin.mod
nafx.mod
nap.mod *
netstim.mod *
NMDA.mod
NMDAIN.mod
sinclamp.mod *
cb.hoc
cr.hoc
ExperimentControl.hoc *
final.hoc
incell.hoc
net.hoc
pfc_pc_temp.hoc
run
run_orig
                            
//Interneuron for PFC - fast spiking parvalbumin interneuron 
//Based on Durstewitz and Gabriel 2006
//"Irregular spiking in NMDA-driven prefrontal cortex neurons"


begintemplate INcell

public soma, axon, dend

create soma, axon, dend


proc init () {

create soma, axon, dend

soma_nafin=0.045  
soma_kdrin=0.018  
soma_Kslowin=0.000725*0.1
soma_hin=0.00001
soma_kapin=0.0032*15  
soma_canin=0.0003
soma_kctin=0.0001

soma {
     nseg=1
     L=27
     diam=29

	insert pas
	cm=1.2            //microF/cm2
	g_pas =1/10000    //mho/cm2   
	e_pas = v_initin   //(Kawaguchi k Kubota, 1993 --> -73+-3.9)
	v_initin= -73
	Ra=150 

     insert Nafx
     gnafbar_Nafx= soma_nafin

     insert kdrin
     gkdrbar_kdrin= soma_kdrin

     insert IKsin	
     gKsbar_IKsin= soma_Kslowin

     insert hin
     gbar_hin=soma_hin

     insert kapin
     gkabar_kapin=soma_kapin

     insert canin
     gcalbar_canin=soma_canin

     insert kctin
     gkcbar_kctin=soma_kctin

     insert cadynin

}

axon {
	nseg=1
	L=115
	diam=1.5
	
	insert pas
	cm=1.2            //microF/cm2
	g_pas =1/10000  //mho/cm2   
	e_pas = v_initin
	v_initin= -73
	Ra=150 

	insert Nafx
	gnafbar_Nafx=soma_nafin*10 

	insert kdrin
	gkdrbar_kdrin=soma_kdrin*0.5
}


dend {
	nseg=1
	L=22
	diam=7


	insert pas
	cm=1.2            //microF/cm2
	g_pas =1/10000    //mho/cm2   
	e_pas = v_initin//(Kawaguchi k Kubota, 1993 --> -73+-3.9)
	v_initin= -73
	Ra=150

	insert Nafx
	gnafbar_Nafx=0.018*5

	insert kdrin
	gkdrbar_kdrin=0.018*0.5

     	insert kapin
    	gkabar_kapin=soma_kapin*10

}

	ko0_k_ion = 3.82   //mM
 	ki0_k_ion = 140    //mM
	celsius   = 23
	connect axon(0), soma(0.5)
	connect dend(0), soma(0)  
}

init()

endtemplate INcell

//Creating new interneurons

nINcells = 2
objref INcells[nINcells]

for i = 0, nINcells-1 {
INcells[i] = new INcell()
}

//Create list with segments
objref insoma_list, incell_list

insoma_list = new SectionList()
for i=0, nINcells-1 {
INcells[i].soma insoma_list.append()
}

incell_list = new SectionList()
for i=0, nINcells-1 {
INcells[i].soma incell_list.append()
INcells[i].axon incell_list.append()
INcells[i].dend incell_list.append()
}

xopen("../bash_templates/current-balancein.hoc")
current_balancein(-73)  

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