Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)

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Accession:168310
This is a model network of prefrontal cortical microcircuit based primarily on rodent data. It includes 16 pyramidal model neurons, 2 fast spiking interneuron models, 1 regular spiking interneuron model and 1 irregular spiking interneuron model. The goal of the paper was to use this model network to determine the role of specific interneuron subtypes in persistent activity
Reference:
1 . Konstantoudaki X, Papoutsi A, Chalkiadaki K, Poirazi P, Sidiropoulou K (2014) Modulatory effects of inhibition on persistent activity in a cortical microcircuit model. Front Neural Circuits 8:7 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron; Neocortex spiking irregular interneuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I_Ks; I_KD;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Synchronization; Active Dendrites;
Implementer(s): Sidiropoulou, Kyriaki [sidirop at imbb.forth.gr]; Konstantoudaki, Xanthippi [xeniakons at gmail.com];
Search NeuronDB for information about:  GabaA; GabaB; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I_Ks; I_KD; Gaba; Glutamate;
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KonstantoudakiEtAl2014
experiment
data
ampa.mod *
ampain.mod *
cadyn.mod *
cadynin.mod *
cal.mod *
calc.mod *
calcb.mod *
can.mod *
cancr.mod *
canin.mod *
car.mod *
cat.mod *
catcb.mod *
gabaa.mod *
gabaain.mod *
gabab.mod *
h.mod *
hcb.mod *
hin.mod *
ican.mod *
iccb.mod *
iccr.mod *
icin.mod *
iks.mod *
ikscb.mod *
ikscr.mod *
iksin.mod *
kadist.mod *
kadistcr.mod *
kadistin.mod *
kaprox.mod *
kaproxcb.mod *
kaproxin.mod *
kca.mod *
kcain.mod *
kct.mod *
kctin.mod *
kdr.mod *
kdrcb.mod *
kdrcr.mod *
kdrin.mod *
naf.mod *
nafcb.mod *
nafcr.mod *
nafin.mod *
nafx.mod *
nap.mod *
netstim.mod *
NMDA.mod *
NMDAIN.mod *
sinclamp.mod *
cb.hoc
cr.hoc
ExperimentControl.hoc *
final.hoc
incell.hoc
net.hoc
pfc_pc_temp.hoc
run
run_orig
                            
//Interneuron for PFC - fast spiking parvalbumin interneuron 
//Based on Durstewitz and Gabriel 2006
//"Irregular spiking in NMDA-driven prefrontal cortex neurons"


begintemplate INcell

public soma, axon, dend

create soma, axon, dend


proc init () {

create soma, axon, dend

soma_nafin=0.045  
soma_kdrin=0.018  
soma_Kslowin=0.000725*0.1
soma_hin=0.00001
soma_kapin=0.0032*15  
soma_canin=0.0003
soma_kctin=0.0001

soma {
     nseg=1
     L=27
     diam=29

	insert pas
	cm=1.2            //microF/cm2
	g_pas =1/10000    //mho/cm2   
	e_pas = v_initin   //(Kawaguchi k Kubota, 1993 --> -73+-3.9)
	v_initin= -73
	Ra=150 

     insert Nafx
     gnafbar_Nafx= soma_nafin

     insert kdrin
     gkdrbar_kdrin= soma_kdrin

     insert IKsin	
     gKsbar_IKsin= soma_Kslowin

     insert hin
     gbar_hin=soma_hin

     insert kapin
     gkabar_kapin=soma_kapin

     insert canin
     gcalbar_canin=soma_canin

     insert kctin
     gkcbar_kctin=soma_kctin

     insert cadynin

}

axon {
	nseg=1
	L=115
	diam=1.5
	
	insert pas
	cm=1.2            //microF/cm2
	g_pas =1/10000  //mho/cm2   
	e_pas = v_initin
	v_initin= -73
	Ra=150 

	insert Nafx
	gnafbar_Nafx=soma_nafin*10 

	insert kdrin
	gkdrbar_kdrin=soma_kdrin*0.5
}


dend {
	nseg=1
	L=22
	diam=7


	insert pas
	cm=1.2            //microF/cm2
	g_pas =1/10000    //mho/cm2   
	e_pas = v_initin//(Kawaguchi k Kubota, 1993 --> -73+-3.9)
	v_initin= -73
	Ra=150

	insert Nafx
	gnafbar_Nafx=0.018*5

	insert kdrin
	gkdrbar_kdrin=0.018*0.5

     	insert kapin
    	gkabar_kapin=soma_kapin*10

}

	ko0_k_ion = 3.82   //mM
 	ki0_k_ion = 140    //mM
	celsius   = 23
	connect axon(0), soma(0.5)
	connect dend(0), soma(0)  
}

init()

endtemplate INcell

//Creating new interneurons

nINcells = 2
objref INcells[nINcells]

for i = 0, nINcells-1 {
INcells[i] = new INcell()
}

//Create list with segments
objref insoma_list, incell_list

insoma_list = new SectionList()
for i=0, nINcells-1 {
INcells[i].soma insoma_list.append()
}

incell_list = new SectionList()
for i=0, nINcells-1 {
INcells[i].soma incell_list.append()
INcells[i].axon incell_list.append()
INcells[i].dend incell_list.append()
}

xopen("../bash_templates/current-balancein.hoc")
current_balancein(-73)  

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