Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)

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Accession:168310
This is a model network of prefrontal cortical microcircuit based primarily on rodent data. It includes 16 pyramidal model neurons, 2 fast spiking interneuron models, 1 regular spiking interneuron model and 1 irregular spiking interneuron model. The goal of the paper was to use this model network to determine the role of specific interneuron subtypes in persistent activity
Reference:
1 . Konstantoudaki X, Papoutsi A, Chalkiadaki K, Poirazi P, Sidiropoulou K (2014) Modulatory effects of inhibition on persistent activity in a cortical microcircuit model. Front Neural Circuits 8:7 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron; Neocortex spiking irregular interneuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I_Ks; I_KD;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Synchronization; Active Dendrites;
Implementer(s): Sidiropoulou, Kyriaki [sidirop at imbb.forth.gr]; Konstantoudaki, Xanthippi [xeniakons at gmail.com];
Search NeuronDB for information about:  GabaA; GabaB; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I_Ks; I_KD; Gaba; Glutamate;
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KonstantoudakiEtAl2014
experiment
data
ampa.mod *
ampain.mod *
cadyn.mod *
cadynin.mod *
cal.mod *
calc.mod *
calcb.mod *
can.mod *
cancr.mod *
canin.mod *
car.mod *
cat.mod *
catcb.mod *
gabaa.mod *
gabaain.mod *
gabab.mod *
h.mod *
hcb.mod *
hin.mod *
ican.mod *
iccb.mod *
iccr.mod *
icin.mod *
iks.mod *
ikscb.mod *
ikscr.mod *
iksin.mod *
kadist.mod *
kadistcr.mod *
kadistin.mod *
kaprox.mod *
kaproxcb.mod *
kaproxin.mod *
kca.mod *
kcain.mod *
kct.mod *
kctin.mod *
kdr.mod *
kdrcb.mod *
kdrcr.mod *
kdrin.mod *
naf.mod *
nafcb.mod *
nafcr.mod *
nafin.mod *
nafx.mod *
nap.mod *
netstim.mod *
NMDA.mod *
NMDAIN.mod *
sinclamp.mod *
cb.hoc
cr.hoc
ExperimentControl.hoc *
final.hoc
incell.hoc
net.hoc
pfc_pc_temp.hoc
run
run_orig
                            
COMMENT
Since this is an electrode current, positive values of i depolarize the cell
and in the presence of the extracellular mechanism there will be a change
in vext since i is not a transmembrane current but a current injected
directly to the inside of the cell.
ENDCOMMENT

NEURON {
        POINT_PROCESS SinClamp
        RANGE del, dur, pkamp, freq, phase, bias
        ELECTRODE_CURRENT i
}

UNITS {
        (nA) = (nanoamp)
             }

PARAMETER {
        del=0   (ms)
        dur=200   (ms)	:200
        pkamp=0.5 (nA)  :0.5
        freq=1  (Hz)	:1
        phase=0 (rad)
        bias=0  (nA)
        PI=3.14159265358979323846
}

ASSIGNED {
        i (nA)
}

BREAKPOINT {
       if (t < del) {
      i=0   
   }else{ 
            if (t < del+dur) {
           i = pkamp*sin(2*PI*freq*(t-del)/1000+phase)+bias
      }else{ 
           i = 0
}}} 

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