Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)

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Accession:168314
This hippocampus model was developed by matching experimental data, including neuronal behavior, synaptic current dynamics, network spatial connectivity patterns, and short-term synaptic plasticity. Furthermore, it was constrained to perform pattern completion and separation under the effects of acetylcholine. The model was then used to investigate the role of short-term synaptic depression at the recurrent synapses in CA3, and inhibition by basket cell (BC) interneurons and oriens lacunosum-moleculare (OLM) interneurons in containing the unstable spread of excitatory activity in the network.
References:
1 . Hummos A, Franklin CC, Nair SS (2014) Intrinsic mechanisms stabilize encoding and retrieval circuits differentially in a hippocampal network model. Hippocampus 24:1430-48 [PubMed]
2 . Hummos A, Nair SS (2017) An integrative model of the intrinsic hippocampal theta rhythm. PLoS One 12:e0182648 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Dentate gyrus granule GLU cell; Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron; Abstract Izhikevich neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Acetylcholine; Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Epilepsy; Storage/recall;
Implementer(s):
Search NeuronDB for information about:  Dentate gyrus granule GLU cell; Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; Acetylcholine; Gaba; Glutamate;
Source	EC	EC	EC	EC	DGg	DGg	CA3e	CA3e	CA3e	CA3o	CA3b	CA3b	DGg	DGg	DGh	DGb	DGb	CA3e	CA3e	CA3e	CA3e	Emo1e	Emo2e	Emo1i	Emo2i	Emo2e
Target	CA3e	CA3b	DGg	DGb	CA3e	CA3b	CA3e	CA3o	CA3b	CA3e	CA3e	CA3o	DGh	DGb	DGg	DGg	DGh	Emo1e	Emo2e	Emo1i	Emo2i	Emo1i	Emo2i	Emo1e	Emo2e	Emo1e
initW	2	3	1.5	10	0.2	1	0.4	3	3	3	3	3	3	3	0.2	0.2	3	4	1	4	2	2	2	2	2	0.002
Max	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
Min	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25
Delay	5	2	5	2	2	2.2	2	0.9	0.9	1	1	0.9	0.9	0.9	1	1	0.9	5	5	2	2	0.9	0.9	1	1	5
Ratio	0.166	0.4	0.2	0.3	0	0.2	0.3	0.5	0.15	2	3	3	1	0.1	2	2	0.5	0.1	0.3	0.2	0.2	0.5	0.5	2	2	0.2
ConPattern	1	0	0	0	0	0	1	3	1	3	2	2	3	1	3	2	2	0	0	0	0	3	3	3	3	0
Lambda1	20	2.5	2.5	2.5	0.0001	0.0001	5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	10	5	2.5	2.5	2.5	2.5	2.5	2.5	10
Lambda2	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01	0.01
threshold1	0.2	0.2	0.3	0.2	0.3	0.3	0.1	0.2	0.2	0.2	0.1	0.2	0.2	0.2	0.1	0.1	0.2	0.3	0.2	0.2	0.2	0.2	0.2	0.4	0.4	0.2
threshold2	0.4	0.4	0.5	0.4	0.5	0.5	0.2	0.4	0.3	0.7	0.3	0.4	0.4	0.4	0.3	0.3	0.4	0.5	0.5	0.4	0.5	0.5	0.5	0.6	0.6	0.4
tauD1	1	1	1	1	1	1	130	1	300	1	300	1	1	300	1	300	1	1	1	1	1	1	1	1	1	1
d1	1	1	1	1	1	1	0.7	1	0.8	1	0.7	1	1	0.8	1	0.7	1	1	1	1	1	1	1	1	1	1
tauD2	1	1	1	1	1	1	400	1	20	1	1	1	1	20	1	1	1	1	1	1	1	1	1	1	1	1
d2	1	1	1	1	1	1	0.92	1	0.5	1	1	1	1	0.5	1	1	1	1	1	1	1	1	1	1	1	1
tauF	1	1	1	1	150	1	1	15	1	1	1	1	15	1	1	1	1	1	1	1	1	15	15	1	1	1
f	1	1	1	1	1.9	1	1	7	1	1	1	1	7	1	1	1	1	1	1	1	1	7	7	1	1	1
erev	0	0	0	0	0	0	0	0	0	-85	-85	-72	0	0	-75	-75	-72	0	0	0	0	0	0	-85	-85	0
bACH	-0.5	-0.5	0	0	0.5	0.5	-0.85	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
aDA	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
bDA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
wACH	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Alpha_ampa	0.58	1.08	0.58	1.08	1.46	2.75	0.9	3.7	3.7	0.35	4.67	7	3.7	3.7	0.35	7	7	0.58	0.58	1.08	1.08	3.7	3.7	0.35	0.35	0.58
Beta_ampa	0.091	0.14	0.091	0.14	0.1	0.09	0.2	1.76	1.76	0.05	0.3	0.25	1.76	1.76	0.05	0.27	0.25	0.091	0.091	0.14	0.14	1.76	1.76	0.05	0.05	0.091
Cdur_ampa	2.4	1.3	2.4	1.3	1.5	0.8	2	0.5	0.5	6.2	0.3	0.25	0.5	0.5	6.2	0.1	0.25	2.4	2.4	1.3	1.3	0.5	0.5	6.2	6.2	2.4
gbar_ampa	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017	0.0017
Alpha_nmda	0.088	0.088	0.088	0.088	0.088	0.088	0.088	0.088	0.088	0.09	0.09	0.09	0.088	0.088	0.09	0.09	0.09	0.088	0.088	0.088	0.088	0.088	0.088	0.09	0.09	0.088
Beta_nmda	0.0033	0.0066	0.0033	0.0066	0.0033	0.0066	0.0033	0.0066	0.0066	0.008	0.008	0.008	0.0066	0.0066	0.008	0.008	0.008	0.0033	0.0033	0.0066	0.0066	0.0066	0.0066	0.008	0.008	0.0033
Cdur_nmda	10	10	10	10	10	10	10	10	10	6	6	6	10	10	6	6	6	10	10	10	10	10	10	6	6	10
gbar_nmda	0.0017	0.0017	0.0006	0.0006	0.0006	0.0006	0.0017	0.0006	0.0006	0.0017	0.0017	0.0006	0.0006	0.0006	0.0006	0.0006	0.0006	0.0017	0.0017	0.0017	0.0017	0.0006	0.0006	0.0006	0.0006	0.0017
GaussA	0	0	0	0	0	0	0	0	0	1.5	1	1	0	0	1	1	0	0	0	0	0	0	0	1.5	1.5	0

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