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The corresponding page is
https://modeldb.science/169457
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Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
 
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Model Information
Model File
Citations
Accession:
169457
Python scripts for running NEURON simulations that model a layer V pyramidal cell with certain genetic variants implemented. The genes included are obtained from genome-wide association studies of schizophrenia.
Reference:
1 .
Mäki-Marttunen T, Halnes G, Devor A, Witoelar A, Bettella F, Djurovic S, Wang Y, Einevoll GT, Andreassen OA, Dale AM (2016) Functional Effects of Schizophrenia-Linked Genetic Variants on Intrinsic Single-Neuron Excitability: A Modeling Study.
Biol Psychiatry Cogn Neurosci Neuroimaging
1
:49-59
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I T low threshold;
I K;
I K,leak;
I M;
I h;
I K,Ca;
I A, slow;
Ca pump;
Gap Junctions:
Receptor(s):
Gene(s):
Nav1.1 SCN1A;
Nav1.7 SCN9A;
Cav3.3 CACNA1I;
Cav1.3 CACNA1D;
Cav1.2 CACNA1C;
Kv2.1 KCNB1;
HCN1;
Transmitter(s):
Simulation Environment:
NEURON;
Python;
Model Concept(s):
Coincidence Detection;
Active Dendrites;
Detailed Neuronal Models;
Schizophrenia;
Implementer(s):
Maki-Marttunen, Tuomo [tuomomm at uio.no];
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
I Na,p
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I K
;
I K,leak
;
I M
;
I h
;
I K,Ca
;
I A, slow
;
Ca pump
;
/
Maki-MarttunenEtAl2015
morphologies
cell1.asc
*
Other models using cell1.asc:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Effect of ionic diffusion on extracellular potentials (Halnes et al 2016)
Four-pathway phenomenological synaptic plasticity model (Ebner et al. 2019)
L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011)
Layer 5 Pyramidal Neuron (Shai et al., 2015)
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Microcircuits of L5 thick tufted pyramidal cells (Hay & Segev 2015)
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Shaping NMDA spikes by timed synaptic inhibition on L5PC (Doron et al. 2017)
cell2.asc
*
Other models using cell2.asc:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Four-pathway phenomenological synaptic plasticity model (Ebner et al. 2019)
L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011)
Layer 5 Pyramidal Neuron (Shai et al., 2015)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
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