Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of Fast-Spiking Interneurons Reduces beta-Band Oscillations and Imbalance in Firing in the Dopamine-Depleted Striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
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DamodaranEtAl2015
Conditions
No_DA
MScell
channels
unusedChannels
#MScell08CM3_D1.p#
AddCaSpines.g *
addchans.g *
addinput.g *
addoutput.g *
addoutput_old.g *
AddSynapticChannels.g *
connectCaChannels.g *
DA_files.txt *
globals.g
globalsCaComp.g *
include_channels.g *
MScell.p *
MScell_D1.g *
MScell_D1_old.g *
MScell_D2.g *
MScell08.p *
MScell08CM3_D1.p *
MScell08CM3_D2.p *
MScellSpine.g *
MScellSpineCtx.g *
MScellSpineTh.g *
MScellSyn_D1.g *
MScellSyn_D2.g *
parametersA_D1.g *
parametersA_D2.g *
parametersB.g *
parametersC.g *
parametersD.g *
proto.g *
spines.g *
SynParams_D1.g
SynParams_D2.g
SynParamsCtx.g *
SynParamsTh.g *
                            
//genesis

/***************************		MS Model, Version 5.12	**********************
**************************** 	     SynapticChannels.g 	**********************
Tom Sheehan tsheeha2@gmu.edu	thsheeha@vt.edu	703-538-8361
******************************************************************************/

/* needs work to remove need for caBuffer at this point */

function addNMDAchannel(compPath, chanpath,caBuffer, gbar, ghk)

  str compPath, chanpath
  float gbar
  str caBuffer 

  copy /library/{chanpath} {compPath}/{chanpath}
  addmsg {compPath} {compPath}/{chanpath}/block VOLTAGE Vm
  addmsg {compPath} {compPath}/{chanpath} VOLTAGE Vm
  if (ghk==0)
    addmsg {compPath}/{chanpath}/block {compPath} CHANNEL Gk Ek
  end

  if (ghk==1)
    addmsg {compPath} {compPath}/{chanName}/GHK VOLTAGE Vm
    addmsg {compPath}/{chanName}/GHK {compPath} CHANNEL Gk Ek
  end

  // Set the new conductance
  float len = {getfield {compPath} len}
  float dia = {getfield {compPath} dia}
  float pi = 3.141592653589793
  float surf = {len*dia*pi}

/*	echo "XXXXXXXXXXXXXXX addNMDAchannel XXXXXXXXXXXXXXXX"
	echo "compPath = "{compPath}
	echo "chanpath = "{chanpath}
	echo "caBuffer = "{caBuffer}
	echo "gbar = "{gbar}
	echo "XXXXXXXXXXXXXXX addNMDAchannel XXXXXXXXXXXXXXXX"
*/
//  setfield {compPath}/{chanName} gmax {surf*gbar}
  setfield {compPath}/{chanpath} gmax {gbar}

  // WE NEED TO ADD CA DYNAMICS, use 10% of current to CaL buffer


 if ({isa dif_shell  {compPath}/{caBuffer}} )         // dif_shell 
  //    echo spine calcium model is dif_shell
 addmsg {compPath}/{chanpath}/block {compPath}/{caBuffer} FINFLUX Ik 0.1
 
  elif ({isa Ca_concen {compPath}/{caBuffer}})      // Ca_conc
 //     echo spine calcium model is Ca_conc
 addmsg {compPath}/{chanpath}/block {compPath}/{caBuffer} fI_Ca Ik 0.1
  end


end


function addSynChannel (compPath, chanpath, gbar)

  str compPath, chanpath
  float gbar

  copy /library/{chanpath} {compPath}/{chanpath}

  addmsg {compPath} {compPath}/{chanpath} VOLTAGE Vm
  addmsg {compPath}/{chanpath} {compPath} CHANNEL Gk Ek

  // Set the new conductance
  float len = {getfield {compPath} len}
  float dia = {getfield {compPath} dia}
  float pi = 3.141592653589793
  float surf = {len*dia*pi}

/*	echo "XXXXXXXXXXXXXXX addSynChannel XXXXXXXXXXXXXXXX"
	echo "compPath = "{compPath}
	echo "chanpath = "{chanpath}
	echo "gbar = "{gbar}
	echo "XXXXXXXXXXXXXXX addSynchannel XXXXXXXXXXXXXXXX"
*/

//  setfield {compPath}/{chanName} gmax {surf*gbar}
  setfield {compPath}/{chanpath} gmax {gbar}
end
 
 

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