Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of fast-spiking interneurons reduces ß-band oscillations and imbalance in firing in the dopamine-depleted striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
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DamodaranEtAl2015
Conditions
No_DA
MScell
channels
ampa_channel.g *
BKKchannel.g *
CaL12inact_channel.g *
CaL13_channel.g *
CaNinact_channel.g *
CaR_channel.g *
CaT_channel.g *
gaba_channel.g
K_DR_channel.g *
kAf_chanRE.g *
kAs_chanRE.g *
kIR_chanKD.g *
naF_chanOg.g *
nmda_channel.g *
SKchannelCaDep.g *
synaptic_channel.g *
tabchanforms.g *
                            
//genesis

/***************************		MS Model, Version 5.0	*********************
**************************** 	    	BKKchannel.g 			*********************
		Tom Sheehan tsheeha2@gmu.edu	thsheeha@vt.edu	703-538-8361
******************************************************************************
******************************************************************************/

//==========================================================================
// /* non-inactivating BK-type Ca-dependent K current
// ** Moczydlowski and Latorre 1983, J. Gen. Physiol. 82:511-542.
// ** Implemented by Erik De Schutter BBF-UIA,
// ** with original parameters scaled for units: V, sec, mM. 
// ** Assumes tab2Dchannel "KC" has a sibling Ca_concen "Ca_conc". 
// ** Temprature is modified to be 35C                                      */

// //=======================================================================

function make_BKK_channel
    float EK=-0.9  // V
  //  int xdivs = 299
    int xdivs = 299
    int ydivs = {xdivs}
    float xmin, xmax, ymin, ymax
    xmin = -0.1; xmax = 0.05; ymin = 0.0; ymax = 0.005 // x = Vm, y = [Ca],mM
    int i, j
    float x, dx, y, dy, a, b
    float Temp = 35
    float ZFbyRT = 23210/(273.15 + Temp)
    if (!({exists BKK_channel}))
        create tab2Dchannel BKK_channel
        setfield BKK_channel Ek {EK} Gbar 0.0  \
            Xindex {VOLT_C1_INDEX} Xpower 1 Ypower 0 Zpower 0
        call BKK_channel TABCREATE X {xdivs} {xmin} {xmax} \
            {ydivs} {ymin} {ymax}
    end
    dx = (xmax - xmin)/xdivs
    dy = (ymax - ymin)/ydivs
    x = xmin
    for (i = 0; i <= xdivs; i = i + 1)
        y = ymin
        for (j = 0; j <= ydivs; j = j + 1)
            a = 480*y/(y + 0.180*{exp {-0.84*ZFbyRT*x}})
            b = 280/(1 + y/(0.011*{exp {-1.00*ZFbyRT*x}}))
            setfield BKK_channel X_A->table[{i}][{j}] {a}
            setfield BKK_channel X_B->table[{i}][{j}] {a + b}
            y = y + dy
        end
        x = x + dx
    end
    setfield BKK_channel X_A->calc_mode {LIN_INTERP}
    setfield BKK_channel X_B->calc_mode {LIN_INTERP}

end




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