Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

 Download zip file 
Help downloading and running models
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of Fast-Spiking Interneurons Reduces beta-Band Oscillations and Imbalance in Firing in the Dopamine-Depleted Striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
AddSynapticChannels.g *
cellMorphology.g *
errorHandler.g *
FScell.g *
FScell.p *
FScellSyn.g *
include_channels.g *
proto.g *
SynParams.g *
// Johannes Hjorth, june 2005
// Sriraman Damodaran, september 2010
// FScell.g - Creates a fast spiking neuron in the library
// make_FS_cell -- Creates the library template for a FS-neuron 
include FScell/proto.g

//************************ Begin function set_position *********************
function set_position (cellpath)
//********************* Begin Local Variables ************************
str compt, cellpath
float dist2soma,x,y,z
//********************* End Local Variables *****************************
if (!{exists {cellpath}})
  echo The current input {cellpath} does not exist (set_position) 
  foreach compt ({el {cellpath}/##[TYPE=compartment]})
     	 x={getfield {compt} x}
     	 y={getfield {compt} y}
     	 z={getfield {compt} z}
     	dist2soma={sqrt {({pow {x} 2 }) + ({pow {y} 2}) + ({pow {z} 2})} }  
     	setfield {compt} position {dist2soma}
	//************************ End function set_position ***********************

function make_FS_cell (cellpath,pfile)
  str cellpath,pfile

  make_prototypes		// see proto.g
  readcell {pfile} {cellpath}
  set_position {cellpath}	// local call
// Number of inputs to each compartmenttype

  addfield {cellpath} somaDensityAMPA
  addfield {cellpath} somaDensityNMDA
  addfield {cellpath} somaDensityGABA

  addfield {cellpath} primDensityAMPA
  addfield {cellpath} primDensityNMDA
  addfield {cellpath} primDensityGABA

  addfield {cellpath} secDensityAMPA
  addfield {cellpath} secDensityNMDA
  addfield {cellpath} secDensityGABA

  addfield {cellpath} tertDensityAMPA
  addfield {cellpath} tertDensityNMDA
  addfield {cellpath} tertDensityGABA

// Weights of each input

  addfield {cellpath} somaWeightAMPA
  addfield {cellpath} somaWeightNMDA
  addfield {cellpath} somaWeightGABA

  addfield {cellpath} primWeightAMPA
  addfield {cellpath} primWeightNMDA
  addfield {cellpath} primWeightGABA

  addfield {cellpath} secWeightAMPA
  addfield {cellpath} secWeightNMDA
  addfield {cellpath} secWeightGABA

  addfield {cellpath} tertWeightAMPA
  addfield {cellpath} tertWeightNMDA
  addfield {cellpath} tertWeightGABA

// Set default values for densities

  setfield {cellpath} somaDensityAMPA 1
  setfield {cellpath} somaDensityNMDA 1
  setfield {cellpath} somaDensityGABA 3

  setfield {cellpath} primDensityAMPA 1
  setfield {cellpath} primDensityNMDA 1
  setfield {cellpath} primDensityGABA 3

  setfield {cellpath} secDensityAMPA  1
  setfield {cellpath} secDensityNMDA  1
  setfield {cellpath} secDensityGABA  3

  setfield {cellpath} tertDensityAMPA 1
  setfield {cellpath} tertDensityNMDA 1
  setfield {cellpath} tertDensityGABA 0

// Set default values for synapse weights

  setfield {cellpath} somaWeightAMPA 1.0
  setfield {cellpath} somaWeightNMDA 1.0
  setfield {cellpath} somaWeightGABA 1.0

  setfield {cellpath} primWeightAMPA 1.0
  setfield {cellpath} primWeightNMDA 1.0
  setfield {cellpath} primWeightGABA 1.0

  setfield {cellpath} secWeightAMPA  1.0
  setfield {cellpath} secWeightNMDA  1.0
  setfield {cellpath} secWeightGABA  1.0

  setfield {cellpath} tertWeightAMPA 1.0
  setfield {cellpath} tertWeightNMDA 1.0
  setfield {cellpath} tertWeightGABA 1.0



Loading data, please wait...