Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

 Download zip file 
Help downloading and running models
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of Fast-Spiking Interneurons Reduces beta-Band Oscillations and Imbalance in Firing in the Dopamine-Depleted Striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
AddSynapticChannels.g *
cellMorphology.g *
errorHandler.g *
FScell.g *
FScell.p *
FScellSyn.g *
include_channels.g *
proto.g *
SynParams.g *
//This routine takes the FScell without synapses, and adds synapses

include FScell/FScell.g                 //FScell without synapses
include FScell/SynParams.g               //parameters on synaptic channels
include FScell/channels/synaptic_channel.g // function to make non nmda synaptic channels in library
include FScell/AddSynapticChannels.g	// contains functions to add channels to compartments

function makeFScellSyn (cellname,pfile)
   str cellname,pfile

   str CompName

   make_FS_cell {cellname} {pfile}

	//************* create synaptic channels in library *********
	pushe /library

  	make_synaptic_channel  {AMPAname} {AMPAtau1} {AMPAtau2} {AMPAgmax} {EkAMPA}
  	make_synaptic_channel  {GABAname} {GABAtau1} {GABAtau2} {GABAgmax} {EkGABA}

        pope {cellname}
   //********************* end synaptic channels in library **************

      foreach CompName ({el {cellname}/##[TYPE=compartment]}) 
        addSynChannel  {CompName} {AMPAname} {AMPAgmax}
        addSynChannel  {CompName} {GABAname} {GABAgmax}


Loading data, please wait...