Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of Fast-Spiking Interneurons Reduces beta-Band Oscillations and Imbalance in Firing in the Dopamine-Depleted Striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
//LFP.g

function LFP_all

	str cName, i
	create efield electrode_all
	create efield electrode_glut
	create efield electrode_gaba

	setfield electrode_all scale 0.26 x 7.5e-5 y 4.0e-4 z 0.00 //s = 0.3 S/m - Linden et al., 2012
	setfield electrode_glut scale 0.26 x 7.5e-5 y 4.0e-4 z 0.00
	setfield electrode_gaba scale 0.26 x 7.5e-5 y 4.0e-4 z 0.00

        for(i = 0; i < {getglobal numCells_SP}; i = {i + 1})
		foreach cName ({el /SPnetwork/SPcell[{i}]/##[TYPE=compartment]})
			addmsg {cName}/AMPA electrode_all CURRENT Ik 0.0
			addmsg {cName}/NR2A electrode_all CURRENT Ik 0.0
			addmsg {cName}/GABA electrode_all CURRENT Ik 0.0

			addmsg {cName}/AMPA electrode_glut CURRENT Ik 0.0
			addmsg {cName}/NR2A electrode_glut CURRENT Ik 0.0

			addmsg {cName}/GABA electrode_gaba CURRENT Ik 0.0
		end

	end
	call electrode_all RECALC
	call electrode_glut RECALC
	call electrode_gaba RECALC
	create asc_file /output/electrode_all
	create asc_file /output/electrode_glut
	create asc_file /output/electrode_gaba
	setfield /output/electrode_all   flush 1  leave_open 1 append 1 float_format %0.6g	
	setfield /output/electrode_glut   flush 1  leave_open 1 append 1 float_format %0.6g	
	setfield /output/electrode_gaba   flush 1  leave_open 1 append 1 float_format %0.6g	
	useclock /output/electrode_all 1e-3
	useclock /output/electrode_glut 1e-3
	useclock /output/electrode_gaba 1e-3
	addmsg /electrode_all /output/electrode_all SAVE field 
	addmsg /electrode_glut /output/electrode_glut SAVE field 
	addmsg /electrode_gaba /output/electrode_gaba SAVE field 

end






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