Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of Fast-Spiking Interneurons Reduces beta-Band Oscillations and Imbalance in Firing in the Dopamine-Depleted Striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
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DamodaranEtAl2015
MScell
channels
unusedChannels
AddCaSpines.g *
addchans.g *
addinput.g *
addoutput.g *
addoutput_old.g *
AddSynapticChannels.g *
connectCaChannels.g *
DA_files.txt *
globals.g
globalsCaComp.g *
include_channels.g *
MScell.p *
MScell_D1.g *
MScell_D1_old.g *
MScell_D2.g *
MScell08.p *
MScell08CM3_D1.p *
MScell08CM3_D2.p *
MScellSpine.g *
MScellSpineCtx.g *
MScellSpineTh.g *
MScellSyn_D1.g *
MScellSyn_D2.g *
parametersA_D1.g *
parametersA_D2.g *
parametersB.g *
parametersC.g *
parametersD.g *
proto.g *
spines.g *
SynParams_D1.g
SynParams_D2.g
SynParamsCtx.g *
SynParamsTh.g *
                            
 //function to add calcium channels to spines 
function addCaChannelspines(channelName, compPath, conductance, caBufferName)
  str channelName, compPath
  float conductance
  str caBufferName

  pushe {compPath}

    // Copy the channel from library
    copy /library/{channelName} {channelName}
    copy /library/{channelName}GHK {channelName}GHK

    // Set the new conductance
    float len = {getfield {compPath} len}
    float dia = {getfield {compPath} dia}
    float pi = 3.141592653589793
    float surf = {len*dia*pi} 

    // echo "Channel: "{channelName}", conductance "{conductance}"S/m²"
    // echo "Compartment: "{compPath}", surface area "{surf}"m²"
    setfield {channelName} Gbar {conductance*surf}

    // Couple channel to caBuffer

coupleCaBufferCaChannel {caBufferName} {compPath} {channelName}

    // Couple channel, its GHK object and compartment together
    addmsg {compPath} {channelName}GHK VOLTAGE Vm
    addmsg {compPath} {channelName} VOLTAGE Vm
    addmsg {channelName}GHK {compPath} CHANNEL Gk Ek
    addmsg {channelName} {channelName}GHK PERMEABILITY Gk

//     float len = {getfield {compPath} len}
//     float dia = {getfield {compPath} dia}
//     float pi = 3.141592653589793
//     float surf = {len*dia*pi}

//     // echo "conductance (unscaled): "{conductance}
//     // echo "Compartment: "{compPath}" surface area "{surf}"m²"
//     setfield {channelName} Gbar {conductance*surf}

  pope

end

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