Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of fast-spiking interneurons reduces ß-band oscillations and imbalance in firing in the dopamine-depleted striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
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DamodaranEtAl2015
MScell
unusedChannels
CaL12_channel.g *
CaL12NOINACT_channel.g *
CaN_channel.g *
CaNNOINACT_channel.g *
CaQ_channel.g *
naP_channel.g *
                            
//genesis

/***************************		MS Model, Version 5.2	*********************
**************************** 	  		CaQ_channel.g 			*********************
		Tom Sheehan tsheeha2@gmu.edu	thsheeha@vt.edu	703-538-8361
******************************************************************************
******************************************************************************/

function create_CaQ
	str chanName = "CaQ_channel"
	str compPath = "/library"

	int c = 0	
	float increment = 0.00005	
	float x = -0.1
	int xdivs = 3000
	float xmin = -0.1
	float xmax = 0.05
  	float mPower = 1.0
  	float hPower = 0.0

	float mvHalfCaQ = -9.0e-3
	float mkCaQ = -6.6e-3
	float mInfCaQ= 0.0
	float mTauCaQ = 0.0

	float surf = 0.0
	float qFactCaN = {3.0/{CaSlow}}
	float gMax = 6.0e-008

	float theta = 0.0
	float theta_exp = 0.0

	pushe {compPath}

	create tabchannel {chanName}
  	setfield {chanName} Xpower {mPower} Ypower {hPower}
	call {chanName} TABCREATE X {xdivs} {xmin} {xmax}

	for(c = 0; c < {xdivs} + 1; c = c + 1)
		/************************ Begin CaQ_mTau *********************/
		//mTauCaQ   = 0.377e-3*ones(vDiv+1,1);
		mTauCaQ = 3.77e-004
		setfield {chanName} X_A->table[{c}] {mTauCaQ}
		/************************ End CaQ_mTau ***********************/
		
		/************************ Begin CaQ_mInf *********************/
		//mInfCaQ   = 1./(1 + exp((vMemb - mvHalfCaQ)/mkCaQ));
		theta = {{x} - {mvHalfCaQ}}/{mkCaQ}
		theta_exp = {exp {theta}} + 1.0
		mInfCaQ = 1.0/{theta_exp}
		setfield {chanName} X_B->table[{c}] {mInfCaQ}
		/************************ End CaQ_mInf ***********************/
    	x = x + increment
	end

	tweaktau {chanName} X

  	create ghk {chanName}GHK

  	setfield {chanName}GHK Cout 2 // Carter & Sabatini 2004 uses 2mM, 
											// Wolf 5mM
  	setfield {chanName}GHK valency 2.0
  	setfield {chanName}GHK T {TEMPERATURE}
	
  	setfield {chanName} Gbar {gMax*surf}
  	addmsg {chanName} {chanName}GHK PERMEABILITY Gk	
  	pope 
end


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